Immunotherapy after surgery may keep early lung cancer at bay
NCT ID NCT04317534
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study is for people with stage I non-small cell lung cancer who have had their tumor surgically removed. It compares receiving the immunotherapy drug pembrolizumab every 6 weeks for about a year versus simply being watched (observation). The goal is to see if pembrolizumab can delay or prevent the cancer from coming back. About 244 participants will be randomly assigned to one of the two groups.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
pembrolizumab (an immunotherapy drug)
What this could lead to
If successful, this could offer a way to reduce the risk of cancer returning after surgery for early-stage lung cancer patients.
What could go wrong
This is a phase 2 trial with a moderate number of participants, so results are not definitive. Immunotherapy can cause immune-related side effects, and the benefit over observation alone is not yet proven.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Locations
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Indiana University Melvin and Bren Simon Cancer Center
RECRUITINGIndianapolis, Indiana, 46202, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Moffit Cancer Center
RECRUITINGTampa, Florida, 33612, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Ohio State University Comprehensive Cancer Center
RECRUITINGColumbus, Ohio, 43210, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Penn State Cancer Institute
RECRUITINGHershey, Pennsylvania, 17033, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Providence Health & Services - Oregon
RECRUITINGPortland, Oregon, 97213, United States
Contact Email: •••••@•••••
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Rutgers Cancer Institute of New Jersey
RECRUITINGNew Brunswick, New Jersey, 08903, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Univeristy of Wisconsin
RECRUITINGMadison, Wisconsin, 53705, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Illinois Cancer Center
RECRUITINGChicago, Illinois, 60612, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Iowa Hospitals and Clinics
RECRUITINGIowa City, Iowa, 52242, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Minnesota
RECRUITINGMinneapolis, Minnesota, 55455, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Nebraska Medical Center
RECRUITINGOmaha, Nebraska, 68198, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Virginia Health System
RECRUITINGCharlottesville, Virginia, 22908, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Virginia Commonwealth University
RECRUITINGRichmond, Virginia, 23298, United States
Contact Email: •••••@•••••
Contact