New drug targets hidden heart risk factor in 340 patients

NCT ID NCT06813911

Recruiting now Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 14, 2026 · Updated 27 times

Summary

This study tests a new medicine called pelacarsen in people with heart disease who have high levels of a blood fat called Lp(a), which increases heart attack risk. Participants will also receive another cholesterol-lowering drug, inclisiran. The goal is to see if pelacarsen can safely lower Lp(a) levels more than a placebo over 6 months. About 340 adults aged 18 to 80 with established heart or blood vessel disease are being recruited.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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AB Clinical Trials
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Las Vegas, Nevada, 89119, United States

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Aa Mrc Llc
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Flint, Michigan, 48504, United States

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Advocate Lutheran General Childrens Hospital
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Park Ridge, Illinois, 60068, United States

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American Health Network Research Dept
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Muncie, Indiana, 47304, United States
American Health Network Research Dept
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Muncie, Indiana, 47304, United States

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Anderson Medical Research
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Ft. Washington, Maryland, 20744, United States

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Baptist Health South
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Miami, Florida, 33173, United States

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Cardiovascular Associates Research
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Covington, Louisiana, 70433, United States

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Clinical Research Inst of Arizona
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Sun City West, Arizona, 85375, United States

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Excel Medical Clinical Trials LLC
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Boca Raton, Florida, 33434, United States

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FC Site Partners Miami
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Winter Park, Florida, 32789, United States

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FXM Clin Res Miramar LLC
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Miramar, Florida, 33027, United States

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Flourish Research Bowie
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Bowie, Maryland, 20715, United States

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Henry Ford Hospital
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Detroit, Michigan, 48202, United States

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Inpatient Research Clinical LLC
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Miami Lakes, Florida, 33014, United States
Inpatient Research Clinical LLC
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Miami Lakes, Florida, 33014, United States

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Intermountain Medical Center
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Murray, Utah, 84107, United States

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Interv Cardiology Med Grp
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West Hills, California, 91307, United States

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Jacksonville Center for Clinical
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Jacksonville, Florida, 32216, United States

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K2 Medical Research LLC
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Maitland, Florida, 32751, United States

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Kelsey Seybold Research Foundation
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Houston, Texas, 77030, United States

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Latin Clinical Trial Center Inc
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San Juan, 00909, Puerto Rico

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MyMichigan Medical Center Midland
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Midland, Michigan, 48670, United States

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National Heart Institute
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Beverly Hills, California, 90211, United States

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Northwest Houston Clinical Research PLLC
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Tomball, Texas, 77375, United States

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Novartis Investigative Site
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Tullahoma, Tennessee, 37388, United States

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Novartis Investigative Site
ACTIVE_NOT_RECRUITING

Yinchuan, Ningxia, 750004, China
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Jining, Shandong, 272000, China
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Xian, Shanxi, 710061, China
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Beijing, 100730, China
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Shanghai, 200025, China
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Béziers, 34525, France
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Cholet, 49325, France
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Grenoble, 38043, France
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Lille, 59037, France
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Montpellier, 34295, France
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Paris, 75013, France
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Pessac, 33604, France
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Poitiers, 86021, France
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Toulouse, 31054, France
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Stuttgart, Baden-Wurttemberg, 70376, Germany
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Potsdam, Brandenburg, 14473, Germany
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Chemnitz, Saxony, 09113, Germany
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Leipzig, Saxony, 04103, Germany
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Berlin, 10789, Germany
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Bielefeld, 33604, Germany
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Gelnhausen, 63571, Germany
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Mannheim, 68165, Germany
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Münster, 48145, Germany
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Singen, 78224, Germany
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Hong Kong, Hong Kong, 999077, Hong Kong
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Hong Kong, 999077, Hong Kong
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Ancona, AN, 60126, Italy
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Caserta, CE, 81100, Italy
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Grosseto, GR, 58100, Italy
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Milan, MI, 20138, Italy
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Rozzano, MI, 20089, Italy
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Perugia, PG, 06129, Italy
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Pordenone, PN, 33170, Italy
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Salerno, SA, 84131, Italy
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Legnago, VR, 37045, Italy
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The Hague, South Holland, 2545 AA, Netherlands
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Enschede, 7512KZ, Netherlands
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Santiago Compostela, A Coruna, 15706, Spain
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Pamplona, Navarre, 31008, Spain
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Castilleja de la Cuesta, Sevilla, 41950, Spain
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A Coruña, 15006, Spain
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Barcelona, 08023, Spain
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Córdoba, 14004, Spain
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Huelva, 21080, Spain
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Las Palmas GC, 35010, Spain
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Salamanca, 37007, Spain
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Valencia, 46010, Spain
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Valencia, 46014, Spain
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Changhua, 50006, Taiwan
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Kaohsiung City, 80756, Taiwan
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Tainan, 704, Taiwan
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Taipei, 10002, Taiwan
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Taipei, 11217, Taiwan
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Chichester, West Sussex, PO19 6SE, United Kingdom
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London, EC1M 6BQ, United Kingdom
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London, W12 0HS, United Kingdom
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Manchester, M13 9WL, United Kingdom
Novartis Investigative Site
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Tyne and Wear, NE29 8NH, United Kingdom
Ocala Cardiovascular Research
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Ocala, Florida, 34471, United States

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Omega Clinical Research
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Metairie, Louisiana, 70006, United States

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Overlook Medical Center
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Summit, New Jersey, 07901, United States

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Parkway Medical Center
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Birmingham, Alabama, 35215, United States

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Peace River Cardiovascular Center
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Port Charlotte, Florida, 33952, United States

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PharmaTex Research LLC
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Amarillo, Texas, 79106, United States

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SEC Clinical Research
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Pensacola, Florida, 32503, United States

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The Corvallis Clinic P C
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Corvallis, Oregon, 97330, United States

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University Of South Florida
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Tampa, Florida, 33612, United States

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University of Miami Hospital
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Miami, Florida, 33136, United States

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Virginia Heart
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Falls Church, Virginia, 22042, United States

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Wake Forest University Baptist Medical Center
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Winston-Salem, North Carolina, 27157, United States

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Conditions

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ATHEROSCLEROTIC CARDIOVASCULAR DISEASE (ASCVD)