New enzyme combo aims to shrink hard-to-treat pancreatic tumors
NCT ID NCT02921022
First seen Dec 16, 2025 · Last updated Apr 24, 2026 · Updated 13 times
Summary
This study tests whether adding an experimental drug called PEGPH20 to standard chemotherapy (gemcitabine and nab-paclitaxel) and a blood thinner (rivaroxaban) can help shrink advanced pancreatic cancer. PEGPH20 breaks down a substance called hyaluronan, which is often found in large amounts in pancreatic tumors and may help them grow. The study includes about 110 adults with advanced pancreatic cancer that cannot be removed by surgery. Researchers are monitoring side effects, especially blood clots, and checking how well the treatment works.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Hartford Healthcare Cancer Institute @ Hartford Hospital
Hartford, Connecticut, 06102, United States
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Lehigh Valley Health Network
Allentown, Pennsylvania, 18103, United States
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Memorial Sloan Kettering Basking Ridge
Basking Ridge, New Jersey, United States
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Memorial Sloan Kettering Bergen
Montvale, New Jersey, 07645, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Memorial Sloan Kettering Commack
Commack, New York, 11725, United States
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Memorial Sloan Kettering Monmouth
Middletown, New Jersey, 07748, United States
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Memorial Sloan Kettering Nassau
Uniondale, New York, 11553, United States
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Memorial Sloan Kettering Westchester
Harrison, New York, 10604, United States
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Miami Cancer Institute
Miami, Florida, 33143, United States
Conditions
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