Cure My Disease

Don't miss your cure!

 Log in / Sign up

Can tailored lung pressure protect the brain during prostate surgery?

NCT ID NCT07784010

Disease control Sponsor: Istanbul University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 25, 2026 · Last updated Aug 26, 2026 · Updated 1 time

Summary

This trial tests whether personalizing the air pressure used during mechanical ventilation (called PEEP) can better protect brain blood flow and thinking skills after robotic prostate surgery. About 45 adults having robot-assisted prostatectomy will be randomly assigned to either a standard fixed PEEP or a tailored PEEP chosen to minimize lung strain. Researchers will measure brain blood flow using ultrasound and check attention, memory, and confusion for up to 48 hours after surgery to see if the tailored approach makes a difference.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Individualized PEEP titration (driving pressure-guided) versus standard fixed PEEP during mechanical ventilation
What this could lead to
If individualized PEEP better preserves brain blood flow and oxygenation, it could reduce post-surgery confusion and cognitive decline in patients undergoing robotic prostatectomy.
What could go wrong
This is a small, early-stage trial (45 patients) and results may not apply to all surgeries. The intervention is a standard ventilation adjustment, so benefits may be modest and not always clinically significant.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 45 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Nov 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Male participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 to 80 years American Society of Anesthesiologists (ASA) physical status I-III Scheduled for robot-assisted laparoscopic radical prostatectomy Provision of written informed consent Exclusion Criteria: * Body mass index (BMI) \>35 kg/m² History of surgery requiring at least 1 hour of mechanical ventilation within the previous 2 weeks Severe pulmonary disease New York Heart Association (NYHA) class III-IV heart failure Progressive neuromuscular disease Known cerebrovascular malformation Head or neck anatomical conditions preventing adequate transcranial Doppler ultrasonography Refusal to participate in the study Intraoperative conversion to open surgery

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Cerebral hemodynamics are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cerebral hemodynamics Mechanical ventilation strategies Robotic prostatectomy

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine

    Istanbul, 34077, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.