Could delaying radiation be just as good for advanced nasopharyngeal cancer?

NCT ID NCT07235319

Recruiting now Disease control Sponsor: Sun Yat-sen University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial is testing whether giving radiation only when needed (salvage therapy) works as well as giving it right away after immunotherapy and chemotherapy in people with nasopharyngeal cancer that has spread. The goal is to see if delaying radiation can reduce side effects without hurting survival. About 260 adults with newly diagnosed metastatic disease will take part.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PD-1 inhibitor (toripalimab, tislelizumab, or camrelizumab) plus chemotherapy (cisplatin) and locoregional radiotherapy
What this could lead to: If successful, this could show that delaying radiotherapy until needed is as effective as immediate treatment, potentially reducing side effects for patients with metastatic nasopharyngeal cancer.
What could go wrong: This is a non-inferiority trial, so it may only confirm that the delayed approach is not worse, not necessarily better. The study is still recruiting and results are years away.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

malignant tumor of nasopharynx nasopharyngeal carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DISTANT METASTASIS NASOPHARANGEAL CANCER

Contacts and locations

Locations

Fujian Cancer Hospital
NOT_YET_RECRUITING

Fuzhou, China
Guangxi Medical University Cancer Hospital
NOT_YET_RECRUITING

Nanning, China
Hunan Cancer Hospital
NOT_YET_RECRUITING

Changsha, China
Sun Yat-sen University Cancer Center
RECRUITING

Guangzhou, Guangdong, 510060, China
Zhejiang Cancer Hospital
NOT_YET_RECRUITING

Hangzhou, China

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