New combo therapy shows promise for rare sarcomas
NCT ID NCT02180867
First seen Jun 27, 2026 ยท Last updated Jun 27, 2026
Summary
This study looked at adding the drug pazopanib to standard radiation or chemoradiation before surgery for patients with certain soft tissue sarcomas. The goal was to see if the combination is safe and helps shrink tumors more effectively. About 140 adults and children with newly diagnosed, removable sarcomas took part. The approach aims to improve tumor control and reduce the chance of cancer returning.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2/3
Runs two stages together: whether the treatment works, then large-scale confirmation.
- Participants
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140 people
The number who actually took part.
- Started
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Aug 2014
- Finished
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Mar 2026
- Lead sponsor
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A government research agency
The lead sponsor is the US National Institutes of Health.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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2 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Note: eligible patients must have a body surface area \>= 0.5 m\^2 AND be able to swallow whole tablets * Newly diagnosed and histopathologically confirmed, potentially resectable NRSTS of the extremity and trunk will be eligible for the chemotherapy or non-chemotherapy cohort based on: * Evidence of chemotherapy sensitivity of the histologic sarcoma subtype based on existing evidence from prior clinical trials * Sufficient risk of metastatic disease to warrant chemotherapy based on size and grade and * Medically deemed able or unable to undergo chemotherapy * Notes: an incisional biopsy or core biopsy is preferred; fine needle aspiration biopsy is not acceptable to establish the diagnosis * ELIGIBLE SITES: * Extremities: upper (including shoulder) and lower (including hip) * Trunk: body wall * INELIGIBLE SITES: Head and neck, visceral organs (with the exception of embryonal sarcoma of the liver), retroperitoneum, peritoneum, pelvis within the confines of the bony pelvis * ELIGIBILITY FOR CHEMOTHERAPY COHORT: * Stage T2a/b (\> 5 cm) and grade 2 or 3 AND * One of the following chemosensitive histologies as defined in the World Health Organization (WHO) classification of soft tissue tumors (with some evidence of good response to chemoradiation and of sufficient high risk of metastases, or clear evidence of metastases): * Unclassified soft tissue sarcomas that are too undifferentiated to be placed in a specific pathologic category in the WHO classification (often called "undifferentiated soft tissue sarcoma" or "soft tissue sarcoma not otherwise specified \[NOS\]") * Synovial sarcoma * Angiosarcoma of soft tissue * Adult fibrosarcoma * Mesenchymal (extraskeletal) chondrosarcoma * Leiomyosarcoma * Liposarcoma (excluding myxoid liposarcoma) * Undifferentiated pleomorphic sarcoma * Embryonal sarcoma of the liver * Patients meeting the above criteria (histology, size, and grade) with the EXCEPTION of histologies noted above may enroll on the chemotherapy cohort or the non-chemotherapy cohort at the discretion of the enrolling investigator; patients meeting these criteria with the EXCEPTION of histologies noted above but medically deemed unable to receive chemotherapy or who elect not to receive chemotherapy are eligible for the non-chemotherapy cohort * Patients with the following histologies are only eligible for the chemotherapy cohort and cannot enroll on the non-chemotherapy cohort: * Unclassified soft tissue sarcomas that are too undifferentiated to be placed in a specific pathologic category in the WHO classification (often called "undifferentiated soft tissue sarcoma" or "soft tissue sarcoma NOS") in patients \< 30 years of age * Synovial sarcoma * Embryonal sarcoma of the liver * ELIGIBILITY FOR NON-CHEMOTHERAPY COHORT: * Patients with any size of grade 2 or 3 of the following "intermediate (rarely metastasizing)" or "malignant" tumors, as defined in the WHO classification of soft tissue tumors for which we have consensus data of chemotherapy-resistance are eligible only for the non-chemotherapy cohort: * So-called fibrohistiocytic tumors - plexiform fibrohistiocytic tumor, giant cell tumor of soft tissues * Fibroblastic/myofibroblastic tumors - solitary fibrous tumor, malignant solitary fibrous tumor, inflammatory myofibroblastic tumor, low grade myofibroblastic sarcoma, myxoinflammatory fibroblastic sarcoma, atypical myxoinflammatory fibroblastic tumor, myxofibrosarcoma, low grade fibromyxoid sarcoma, sclerosing epithelioid fibrosarcoma * Tumors of uncertain differentiation - epithelioid sarcoma, alveolar soft part sarcoma, clear cell sarcoma of soft tissue, angiomatoid fibrous histiocytoma, ossifying fibromyxoid tumor, myoepithelioma, myoepithelial carcinoma, extraskeletal myxoid chondrosarcoma, neoplasms with perivascular epithelioid cell differentiation (PEComa), intimal sarcoma, atypical fibroxanthoma, mixed tumor NOS, phosphaturic mesenchymal tumor, malignant ossifying fibromyxoid tumor, malignant mixed tumor, malignant phosphaturic mesenchymal tumor * Chondro-osseous tumors - extraskeletal osteosarcoma * Pericytic (perivascular) tumors - malignant glomus tumor * Nerve sheath tumors - malignant peripheral nerve sheath tumor, malignant granular cell tumor, epithelioid malignant peripheral nerve sheath tumor, malignant Triton tumor * Undifferentiated sarcomas (with a specific pathologic category in the WHO classification) - undifferentiated round cell sarcoma, undifferentiated epithelioid sarcoma, undifferentiated spindle cell sarcoma * Patients meeting the criteria (histology, size, and grade) with the EXCEPTION of histologies noted above may enroll on the non-chemotherapy cohort at the discretion of the enrolling investigator; patients meeting these criteria with the EXCEPTION of histologies noted above but medically deemed unable to receive chemotherapy or who elect not to receive chemotherapy are eligible for the non-chemotherapy cohort; note that tumors arising in bone are NOT eligible for this study * Extent of disease: * Patients with non-metastatic and metastatic disease are eligible * Initially unresectable patients, with or without metastatic disease, are eligible as long as there is a commitment at enrollment to resect the primary tumor * Sufficient tissue and blood must be available to submit for required biology studies * Lansky performance status score \>= 70 for patients =\< 16 years of age * Karnofsky performance status score \>= 70 for patients \> 16 years of age * Absolute neutrophil count \>= 1500/uL; Note: no transfusions are permitted 7 days prior to laboratory studies to determine eligibility * Platelet count \>= 100,000/uL; Note: no transfusions are permitted 7 days prior to laboratory studies to determine eligibility * Hemoglobin \>= 8 g/dL for patients =\< 16 years of age; \>= 9 g/dL for patients \> 16 years of age; Note: no transfusions are permitted 7 days prior to laboratory studies to determine eligibility * Creatinine clearance or radioisotope glomerular filtration rate (GFR) \>= 70 mL/min/1.73 m\^2 or normal serum creatinine based on age/gender as follows: * 2 to \< 6 years; 0.8 mg/dL male; 0.8 mg/dL female * 6 to \< 10 years; 1 mg/dL male; 1 mg/dL female * 10 to \< 13 years; 1.2 mg/dL male; 1.2 mg/dL female * 13 to \< 16 years; 1.5 mg/dL male; 1.4 mg/dL female * \>= 16 years; 1.5 mg/dL male; 1.4 mg/dL female * Total bilirubin =\< 1.5 x upper limit of normal (ULN) for age * Serum glutamic oxaloacetic transaminase (SGOT) (aspartate aminotransferase \[AST\]) or serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase \[ALT\]) \< 2.5 x upper limit of normal (ULN) for age * Shortening fraction of \>= 27% by echocardiogram OR ejection fraction of \>= 50% by radionuclide angiogram * Corrected QT interval (QTc) \< 480 msec * No evidence of dyspnea at rest, no exercise intolerance, and a resting pulse oximetry reading \> 94% on room air if there is clinical indication for determination * Patients on low molecular weight heparin or Coumadin (with a stable international normalized ratio \[INR\]) are eligible * Patient must have a life expectancy of at least 3 months with appropriate therapy * All patients and/or their parents or legal guardians must sign a written informed consent * All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met Exclusion Criteria: * Patients with grade 1 NRSTS tumors of any size are not eligible * Patients with known central nervous system (CNS) metastases are not eligible; Note: brain imaging is not an eligibility requirement * Patients with evidence of active bleeding or bleeding diathesis will be excluded (Note: patients aged \> 17 years with excess of 2.5 mL of hemoptysis are not eligible) * Patients with gross total resection of the primary tumor prior to enrollment on ARST1321 are NOT eligible; patients who have experienced tumor recurrence after a gross total tumor resection are NOT eligible * Patients with uncontrolled hypertension are ineligible; uncontrolled hypertension is defined as follows: * Patients aged =\< 17 years: greater than 95th percentile systolic and diastolic blood pressure based on age and height which is not controlled by one anti-hypertensive medication * Patients aged \> 17 years: systolic blood pressure \>= 140 mmHg and/or diastolic blood pressure \>= 90 mmHg that is not controlled by one anti-hypertensive medication * Prior Therapy: * Patients must have had no prior anthracycline (e.g., doxorubicin, daunorubicin) or ifosfamide chemotherapy * Patients must have had no prior use of pazopanib or similar multi-targeted tyrosine kinase inhibitors (TKI) * Patients must have had no prior radiotherapy to tumor-involved sites * Note: patients previously treated for a non-NRSTS cancer are eligible provided they meet the prior therapy requirements; patients who have had chemotherapy or radiotherapy within 4 weeks (6 weeks for nitrosoureas or mitomycin C) prior to entering the study or those who have not recovered from adverse events due to agents administered more than 4 weeks earlier are excluded * Other types of invasive malignancy that are not disease free within 3 years except for non-melanoma skin cancer, lentigo maligna, any carcinoma-in-situ or prostate cancer with low risk factors * CYTOCHROME P450 3A4 (CYP3A4) substrates WITH narrow therapeutic indices: patients chronically receiving medications known to be metabolized by CYP3A4 and with narrow therapeutic indices within 7 days prior to study enrollment, including but not limited to pimozide, aripiprazole, triazolam, ergotamine and halofantrine are not eligible; Note: the use of fentanyl is permitted * CYP3A4 Inhibitors: patients chronically receiving drugs that are known potent CYP3A4 inhibitors within 7 days prior to study enrollment, including but not limited to itraconazole, clarithromycin, erythromycin many non-nucleoside reverse-transcriptase inhibitors (NNRTIs), diltiazem, verapamil, and grapefruit juice are not eligible * CYP3A4 Inducers: patients chronically receiving drugs that are known potent CYP3A4 inducers within 14 days prior to study enrollment, including but not limited to carbamazepine, phenobarbital, phenytoin, rifampin, and St. John's wort are not eligible (with the exception of glucocorticoids) * Certain medications that are associated with a risk for QTc prolongation and/or Torsades de Pointes, although not prohibited, should be avoided or replaced with medications that do not carry these risks, if possible * Subjects with any condition that may impair the ability to swallow or absorb oral medications/investigational product including: * Any lesion, whether induced by tumor, radiation or other conditions, which makes it difficult to swallow capsules or pills * Prior surgical procedures affecting absorption including, but not limited to major resection of stomach or small bowel * Active peptic ulcer disease * Malabsorption syndrome * Subjects with any condition that may increase the risk of gastrointestinal bleeding or gastrointestinal perforation, including: * Active peptic ulcer disease * Known intraluminal metastatic lesions * Inflammatory bowel disease (e.g., ulcerative colitis, Crohn's disease) or other gastrointestinal conditions which increase the risk of perforation * History of abdominal fistula, gastrointestinal perforation or intra-abdominal abscess within 28 days prior to beginning study treatment * Subjects with any of the following cardiovascular conditions within the past 6 months * Cerebrovascular accident (CVA) or transient ischemic attack (TIA) * Cardiac arrhythmia * Admission for unstable angina * Cardiac angioplasty or stenting * Coronary artery bypass graft surgery * Pulmonary embolism, untreated deep venous thrombosis (DVT) or DVT which has been treated with therapeutic anticoagulation for less than 6 weeks * Arterial thrombosis * Symptomatic peripheral vascular disease * Class III or IV heart failure as defined by the New York Heart Association (NYHA) functional classification system; a subject who has a history of class II heart failure and is asymptomatic on treatment may be considered eligible * History of serious or non-healing wound, ulcer, or bone fracture * Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements * Patients who are unable to swallow whole tablets are not eligible * Patients with a body surface area \< 0.5 m\^2 are not eligible * Human immunodeficiency virus (HIV)-positive subjects on combination antiretroviral therapy are ineligible because of the potential for pharmacokinetic interactions with pazopanib; in addition, these subjects are at increased risk of lethal infections when treated with marrow-suppressive therapy * Patients who are receiving any other investigational agent(s) * Pregnancy and breast feeding: * Female patients who are pregnant are ineligible due to risks of fetal and teratogenic adverse events as seen in animal/human studies * Lactating females are not eligible unless they have agreed not to breastfeed their infants during treatment and for a period of 1 month following completion of treatment * Female patients of childbearing potential are not eligible unless a negative pregnancy test result has been obtained * Unwillingness to use an effective contraceptive method for the duration of their study participation and for at least 1 month after treatment is completed if sexually active with reproductive potential
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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AIS Cancer Center at San Joaquin Community Hospital
Bakersfield, California, 93301, United States
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AdventHealth Orlando
Orlando, Florida, 32803, United States
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Advocate Children's Hospital-Oak Lawn
Oak Lawn, Illinois, 60453, United States
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Advocate Children's Hospital-Park Ridge
Park Ridge, Illinois, 60068, United States
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Alaska Breast Care and Surgery LLC
Anchorage, Alaska, 99508, United States
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Alaska Oncology and Hematology LLC
Anchorage, Alaska, 99508, United States
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Alaska Women's Cancer Care
Anchorage, Alaska, 99508, United States
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Albany Medical Center
Albany, New York, 12208, United States
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Alfred I duPont Hospital for Children
Wilmington, Delaware, 19803, United States
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Allan Blair Cancer Centre
Regina, Saskatchewan, S4T 7T1, Canada
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Allegheny General Hospital
Pittsburgh, Pennsylvania, 15212, United States
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Allegiance Health
Jackson, Michigan, 49201, United States
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Alliance for Childhood Diseases/Cure 4 the Kids Foundation
Las Vegas, Nevada, 89135, United States
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Anchorage Associates in Radiation Medicine
Anchorage, Alaska, 98508, United States
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Anchorage Oncology Centre
Anchorage, Alaska, 99508, United States
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Arkansas Children's Hospital
Little Rock, Arkansas, 72202-3591, United States
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Armes Family Cancer Center
Findlay, Ohio, 45840, United States
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Ascension Saint Vincent Indianapolis Hospital
Indianapolis, Indiana, 46260, United States
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Atrium Medical Center-Middletown Regional Hospital
Franklin, Ohio, 45005-1066, United States
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Augusta University Medical Center
Augusta, Georgia, 30912, United States
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Aurora Bay Area Medical Group-Marinette
Marinette, Wisconsin, 54143, United States
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Aurora BayCare Medical Center
Green Bay, Wisconsin, 54311, United States
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Aurora Cancer Care-Grafton
Grafton, Wisconsin, 53024, United States
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Aurora Cancer Care-Kenosha South
Kenosha, Wisconsin, 53142, United States
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Aurora Cancer Care-Milwaukee
Milwaukee, Wisconsin, 53209, United States
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Aurora Cancer Care-Milwaukee West
Wauwatosa, Wisconsin, 53226, United States
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Aurora Cancer Care-Racine
Racine, Wisconsin, 53406, United States
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Aurora Cancer Care-Southern Lakes VLCC
Burlington, Wisconsin, 53105, United States
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Aurora Cancer Care-Waukesha
Waukesha, Wisconsin, 53188, United States
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Aurora Health Care Germantown Health Center
Germantown, Wisconsin, 53022, United States
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Aurora Health Center-Fond du Lac
Fond du Lac, Wisconsin, 54937, United States
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Aurora Medical Center in Summit
Summit, Wisconsin, 53066, United States
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Aurora Saint Luke's Medical Center
Milwaukee, Wisconsin, 53215, United States
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Aurora Sinai Medical Center
Milwaukee, Wisconsin, 53233, United States
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Aurora West Allis Medical Center
West Allis, Wisconsin, 53227, United States
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BI-LO Charities Children's Cancer Center
Greenville, South Carolina, 29605, United States
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Banner Children's at Desert
Mesa, Arizona, 85202, United States
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Banner University Medical Center - Tucson
Tucson, Arizona, 85719, United States
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Bay Area Hospital
Coos Bay, Oregon, 97420, United States
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Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston, Texas, 77030, United States
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Beacon Kalamazoo
Kalamazoo, Michigan, 49048, United States
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Blanchard Valley Hospital
Findlay, Ohio, 45840, United States
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Blank Children's Hospital
Des Moines, Iowa, 50309, United States
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British Columbia Children's Hospital
Vancouver, British Columbia, V6H 3V4, Canada
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Broadlawns Medical Center
Des Moines, Iowa, 50314, United States
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Bronson Battle Creek
Battle Creek, Michigan, 49017, United States
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Bronson Methodist Hospital
Kalamazoo, Michigan, 49007, United States
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C S Mott Children's Hospital
Ann Arbor, Michigan, 48109, United States
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CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL)
Quรฉbec, G1V 4G2, Canada
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CHUM - Centre Hospitalier de l'Universite de Montreal
Montreal, Quebec, H2X 3E4, Canada
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CIUSSSEMTL-Hopital Maisonneuve-Rosemont
Montreal, Quebec, H1T 2M4, Canada
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CancerCare Manitoba
Winnipeg, Manitoba, R3E 0V9, Canada
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Cardinal Glennon Children's Medical Center
St Louis, Missouri, 63104, United States
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Carilion Children's
Roanoke, Virginia, 24014, United States
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Carolinas Medical Center/Levine Cancer Institute
Charlotte, North Carolina, 28203, United States
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Case Western Reserve University
Cleveland, Ohio, 44106, United States
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Cedars-Sinai Medical Center
Los Angeles, California, 90048, United States
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Central Care Cancer Center - Bolivar
Bolivar, Missouri, 65613, United States
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Central Care Cancer Center - Garden City
Garden City, Kansas, 67846, United States
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Central Care Cancer Center - Great Bend
Great Bend, Kansas, 67530, United States
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Central Vermont Medical Center/National Life Cancer Treatment
Berlin Corners, Vermont, 05602, United States
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Centre Hospitalier Universitaire Sainte-Justine
Montreal, Quebec, H3T 1C5, Canada
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Children's Healthcare of Atlanta - Arthur M Blank Hospital
Atlanta, Georgia, 30329, United States
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Children's Hospital
London, Ontario, N6A 5W9, Canada
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Children's Hospital Colorado
Aurora, Colorado, 80045, United States
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Children's Hospital Los Angeles
Los Angeles, California, 90027, United States
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Children's Hospital Medical Center of Akron
Akron, Ohio, 44308, United States
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Children's Hospital New Orleans
New Orleans, Louisiana, 70118, United States
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Children's Hospital and Medical Center of Omaha
Omaha, Nebraska, 68114, United States
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Children's Hospital of Alabama
Birmingham, Alabama, 35233, United States
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Children's Hospital of Orange County
Orange, California, 92868, United States
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Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
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Children's Hospital of Pittsburgh of UPMC
Pittsburgh, Pennsylvania, 15224, United States
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Children's Hospital of San Antonio
San Antonio, Texas, 78207, United States
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Children's Hospital of The King's Daughters
Norfolk, Virginia, 23507, United States
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Children's Hospital of Wisconsin
Milwaukee, Wisconsin, 53226, United States
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Children's Hospitals and Clinics of Minnesota - Minneapolis
Minneapolis, Minnesota, 55404, United States
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Children's Mercy Hospitals and Clinics
Kansas City, Missouri, 64108, United States
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Children's National Medical Center
Washington D.C., District of Columbia, 20010, United States
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Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229, United States
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City of Hope Comprehensive Cancer Center
Duarte, California, 91010, United States
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Clackamas Radiation Oncology Center
Clackamas, Oregon, 97015, United States
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Cleveland Clinic Foundation
Cleveland, Ohio, 44195, United States
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Comprehensive Cancer Centers of Nevada
Las Vegas, Nevada, 89148, United States
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Connecticut Children's Medical Center
Hartford, Connecticut, 06106, United States
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Cook Children's Medical Center
Fort Worth, Texas, 76104, United States
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Corewell Health Children's
Royal Oak, Michigan, 48073, United States
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Corewell Health Grand Rapids Hospitals - Butterworth Hospital
Grand Rapids, Michigan, 49503, United States
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Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
Grand Rapids, Michigan, 49503, United States
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Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
Saint Joseph, Michigan, 49085, United States
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Corewell Health Lakeland Hospitals - Niles Hospital
Niles, Michigan, 49120, United States
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Corewell Health Lakeland Hospitals - Saint Joseph Hospital
Saint Joseph, Michigan, 49085, United States
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Corewell Health Reed City Hospital
Reed City, Michigan, 49677, United States
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Covenant Children's Hospital
Lubbock, Texas, 79410, United States
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CoxHealth South Hospital
Springfield, Missouri, 65807, United States
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Cross Cancer Institute
Edmonton, Alberta, T6G 1Z2, Canada
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon, New Hampshire, 03756, United States
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Dayton Children's Hospital
Dayton, Ohio, 45404, United States
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Dayton Physician LLC - Englewood
Dayton, Ohio, 45415, United States
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Dayton Physicians LLC - Troy
Troy, Ohio, 45373, United States
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Dayton Physicians LLC-Atrium
Franklin, Ohio, 45005, United States
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Dayton Physicians LLC-Miami Valley South
Centerville, Ohio, 45459, United States
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Dayton Physicians LLC-Wayne
Greenville, Ohio, 45331, United States
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Dell Children's Medical Center of Central Texas
Austin, Texas, 78723, United States
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Drexel University School of Medicine
Philadelphia, Pennsylvania, 19102, United States
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Driscoll Children's Hospital
Corpus Christi, Texas, 78411, United States
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Duke University Medical Center
Durham, North Carolina, 27710, United States
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East Carolina University
Greenville, North Carolina, 27834, United States
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East Tennessee Childrens Hospital
Knoxville, Tennessee, 37916, United States
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Eastern Maine Medical Center
Bangor, Maine, 04401, United States
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El Paso Children's Hospital
El Paso, Texas, 79905, United States
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Emory University Hospital Midtown
Atlanta, Georgia, 30308, United States
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Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia, 30322, United States
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Essentia Health Cancer Center
Duluth, Minnesota, 55805, United States
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Fox Chase Cancer Center
Philadelphia, Pennsylvania, 19111, United States
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Freeman Health System
Joplin, Missouri, 64804, United States
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Geisinger Medical Center
Danville, Pennsylvania, 17822, United States
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Gene Upshaw Memorial Tahoe Forest Cancer Center
Truckee, California, 96161, United States
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Glens Falls Hospital
Glens Falls, New York, 12801, United States
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Golisano Children's Hospital of Southwest Florida
Fort Myers, Florida, 33908, United States
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Good Samaritan Hospital - Dayton
Dayton, Ohio, 45406, United States
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Greater Dayton Cancer Center
Kettering, Ohio, 45409, United States
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Greenville Health System Cancer Institute-Andrews
Greenville, South Carolina, 29601, United States
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Hackensack University Medical Center
Hackensack, New Jersey, 07601, United States
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HaysMed
Hays, Kansas, 67601, United States
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Henry Ford Cancer Institute-Downriver
Brownstown, Michigan, 48183, United States
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Henry Ford Health Saint John Hospital
Detroit, Michigan, 48236, United States
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Henry Ford Hospital
Detroit, Michigan, 48202, United States
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Henry Ford Macomb Hospital-Clinton Township
Clinton Township, Michigan, 48038, United States
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Henry Ford West Bloomfield Hospital
West Bloomfield, Michigan, 48322, United States
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Hospital for Sick Children
Toronto, Ontario, M5G 1X8, Canada
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Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah, 84112, United States
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Hurley Medical Center
Flint, Michigan, 48503, United States
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IWK Health Centre
Halifax, Nova Scotia, B3K 6R8, Canada
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Indu and Raj Soin Medical Center
Beavercreek, Ohio, 45431, United States
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Inova Fairfax Hospital
Falls Church, Virginia, 22042, United States
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Iowa Lutheran Hospital
Des Moines, Iowa, 50316, United States
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Iowa Methodist Medical Center
Des Moines, Iowa, 50309, United States
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Janeway Child Health Centre
St. John's, Newfoundland and Labrador, A1B 3V6, Canada
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Johns Hopkins All Children's Hospital
St. Petersburg, Florida, 33701, United States
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Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, Maryland, 21287, United States
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Kadlec Clinic Hematology and Oncology
Kennewick, Washington, 99336, United States
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Kaiser Permanente Downey Medical Center
Downey, California, 90242, United States
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Kaiser Permanente Los Angeles Medical Center
Los Angeles, California, 90027, United States
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Kaiser Permanente Moanalua Medical Center
Honolulu, Hawaii, 96819, United States
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Kaiser Permanente Washington
Seattle, Washington, 98112, United States
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Kaiser Permanente-Anaheim
Anaheim, California, 92806, United States
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Kaiser Permanente-Oakland
Oakland, California, 94611, United States
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Kaiser Permanente-Riverside
Riverside, California, 92505, United States
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Kaiser Permanente-San Diego Zion
San Diego, California, 92120, United States
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Kaiser Permanente-San Marcos
San Marcos, California, 92078, United States
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Kaiser San Rafael-Gallinas
San Rafael, California, 94903, United States
-
Kapiolani Medical Center for Women and Children
Honolulu, Hawaii, 96826, United States
-
Katmai Oncology Group
Anchorage, Alaska, 99508, United States
-
Kettering Medical Center
Kettering, Ohio, 45429, United States
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Lankenau Medical Center
Wynnewood, Pennsylvania, 19096, United States
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Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York, New York, 10016, United States
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Legacy Emanuel Children's Hospital
Portland, Oregon, 97227, United States
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Lehigh Valley Hospital - Muhlenberg
Bethlehem, Pennsylvania, 18017, United States
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Lehigh Valley Hospital-Cedar Crest
Allentown, Pennsylvania, 18103, United States
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Loma Linda University Medical Center
Loma Linda, California, 92354, United States
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Los Angeles General Medical Center
Los Angeles, California, 90033, United States
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Loyola University Medical Center
Maywood, Illinois, 60153, United States
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Lucile Packard Children's Hospital Stanford University
Palo Alto, California, 94304, United States
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Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Torrance, California, 90502, United States
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Lurie Children's Hospital-Chicago
Chicago, Illinois, 60611, United States
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Madigan Army Medical Center
Tacoma, Washington, 98431, United States
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Maine Children's Cancer Program
Scarborough, Maine, 04074, United States
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Marshfield Medical Center-Marshfield
Marshfield, Wisconsin, 54449, United States
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Massachusetts General Hospital Cancer Center
Boston, Massachusetts, 02114, United States
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Matthews Radiation Oncology Center
Matthews, North Carolina, 28105, United States
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Mayo Clinic in Rochester
Rochester, Minnesota, 55905, United States
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McMaster Children's Hospital at Hamilton Health Sciences
Hamilton, Ontario, L8N 3Z5, Canada
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MedStar Georgetown University Hospital
Washington D.C., District of Columbia, 20007, United States
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Medical City Dallas Hospital
Dallas, Texas, 75230, United States
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Medical College of Wisconsin
Milwaukee, Wisconsin, 53226, United States
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Medical University of South Carolina
Charleston, South Carolina, 29425, United States
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Memorial Health University Medical Center
Savannah, Georgia, 31404, United States
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Memorial Regional Hospital/Joe DiMaggio Children's Hospital
Hollywood, Florida, 33021, United States
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Mercy Clinic-Rolla-Cancer and Hematology
Rolla, Missouri, 65401, United States
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Mercy Hospital Oklahoma City
Oklahoma City, Oklahoma, 73120, United States
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Mercy Hospital Pittsburg
Pittsburg, Kansas, 66762, United States
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Mercy Hospital Saint Louis
St Louis, Missouri, 63141, United States
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Mercy Hospital Springfield
Springfield, Missouri, 65804, United States
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Methodist Children's Hospital of South Texas
San Antonio, Texas, 78229, United States
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Methodist West Hospital
West Des Moines, Iowa, 50266-7700, United States
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Miami Valley Hospital
Dayton, Ohio, 45409, United States
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Miami Valley Hospital North
Dayton, Ohio, 45415, United States
-
Miami Valley Hospital South
Centerville, Ohio, 45459, United States
-
Michigan State University
East Lansing, Michigan, 48823, United States
-
Miller Children's and Women's Hospital Long Beach
Long Beach, California, 90806, United States
-
Mission Hospital
Asheville, North Carolina, 28801, United States
-
Moffitt Cancer Center
Tampa, Florida, 33612, United States
-
Montefiore Medical Center - Moses Campus
The Bronx, New York, 10467, United States
-
Montefiore Medical Center-Einstein Campus
The Bronx, New York, 10461, United States
-
Montefiore Medical Center-Weiler Hospital
The Bronx, New York, 10461, United States
-
Morristown Medical Center
Morristown, New Jersey, 07960, United States
-
Mount Sinai Hospital
New York, New York, 10029, United States
-
Munson Medical Center
Traverse City, Michigan, 49684, United States
-
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York, New York, 10032, United States
-
NYP/Weill Cornell Medical Center
New York, New York, 10065, United States
-
NYU Langone Hospital - Long Island
Mineola, New York, 11501, United States
-
Nationwide Children's Hospital
Columbus, Ohio, 43205, United States
-
Nemours Children's Clinic - Pensacola
Pensacola, Florida, 32504, United States
-
Nemours Children's Clinic-Jacksonville
Jacksonville, Florida, 32207, United States
-
Nemours Children's Hospital
Orlando, Florida, 32827, United States
-
New York Medical College
Valhalla, New York, 10595, United States
-
Newark Beth Israel Medical Center
Newark, New Jersey, 07112, United States
-
Newman Regional Health
Emporia, Kansas, 66801, United States
-
Nicklaus Children's Hospital
Miami, Florida, 33155, United States
-
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
Yakima, Washington, 98902, United States
-
Northwestern Medicine Cancer Center Delnor
Geneva, Illinois, 60134, United States
-
Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois, 60555, United States
-
Northwestern University
Chicago, Illinois, 60611, United States
-
Norton Children's Hospital
Louisville, Kentucky, 40202, United States
-
Norton Hospital Pavilion and Medical Campus
Louisville, Kentucky, 40202, United States
-
Norton Suburban Hospital and Medical Campus
Louisville, Kentucky, 40207, United States
-
Novant Health Presbyterian Medical Center
Charlotte, North Carolina, 28204, United States
-
OSF Children's Hospital of Illinois
Peoria, Illinois, 61637, United States
-
Ochsner Medical Center Jefferson
New Orleans, Louisiana, 70121, United States
-
Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210, United States
-
Oklahoma Cancer Specialists and Research Institute-Tulsa
Tulsa, Oklahoma, 74146, United States
-
Oncology Hematology Care Inc-Blue Ash
Cincinnati, Ohio, 45242, United States
-
Oncology Hematology Care Inc-Kenwood
Cincinnati, Ohio, 45236, United States
-
Oncology Las Vegas - Henderson
Henderson, Nevada, 89074, United States
-
Oregon Health and Science University
Portland, Oregon, 97239, United States
-
Orion Cancer Care
Findlay, Ohio, 45840, United States
-
Parkland Memorial Hospital
Dallas, Texas, 75235, United States
-
PeaceHealth Saint John Medical Center
Longview, Washington, 98632, United States
-
PeaceHealth Saint Joseph Medical Center
Bellingham, Washington, 98225, United States
-
PeaceHealth Southwest Medical Center
Vancouver, Washington, 98664, United States
-
Penn State Children's Hospital
Hershey, Pennsylvania, 17033, United States
-
Phelps Health Delbert Day Cancer Institute
Rolla, Missouri, 65401, United States
-
Phoenix Childrens Hospital
Phoenix, Arizona, 85016, United States
-
Poudre Valley Hospital
Fort Collins, Colorado, 80524, United States
-
Primary Children's Hospital
Salt Lake City, Utah, 84113, United States
-
Prisma Health Cancer Institute - Butternut
Greenville, South Carolina, 29605, United States
-
Prisma Health Cancer Institute - Eastside
Greenville, South Carolina, 29615, United States
-
Prisma Health Cancer Institute - Faris
Greenville, South Carolina, 29605, United States
-
Prisma Health Cancer Institute - Greer
Greer, South Carolina, 29650, United States
-
Prisma Health Cancer Institute - Seneca
Seneca, South Carolina, 29672, United States
-
Prisma Health Cancer Institute - Spartanburg
Boiling Springs, South Carolina, 29316, United States
-
Prisma Health Greenville Memorial Hospital
Greenville, South Carolina, 29605, United States
-
Prisma Health Richland Hospital
Columbia, South Carolina, 29203, United States
-
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
Toledo, Ohio, 43606, United States
-
Providence Alaska Medical Center
Anchorage, Alaska, 99508, United States
-
Providence Portland Medical Center
Portland, Oregon, 97213, United States
-
Providence Regional Cancer Partnership
Everett, Washington, 98201, United States
-
Providence Regional Cancer System-Aberdeen
Aberdeen, Washington, 98520, United States
-
Providence Regional Cancer System-Centralia
Centralia, Washington, 98531, United States
-
Providence Regional Cancer System-Lacey
Lacey, Washington, 98503, United States
-
Providence Sacred Heart Medical Center and Children's Hospital
Spokane, Washington, 99204, United States
-
Providence Saint Joseph Medical Center/Disney Family Cancer Center
Burbank, California, 91505, United States
-
Providence Saint Mary Regional Cancer Center
Walla Walla, Washington, 99362, United States
-
Providence Saint Vincent Medical Center
Portland, Oregon, 97225, United States
-
Radiation Oncology Associates
Reno, Nevada, 89509, United States
-
Radiation Oncology Centers of Nevada Central
Las Vegas, Nevada, 89106, United States
-
Rady Children's Hospital - San Diego
San Diego, California, 92123, United States
-
Rainbow Babies and Childrens Hospital
Cleveland, Ohio, 44106, United States
-
Reid Health
Richmond, Indiana, 47374, United States
-
Renown Regional Medical Center
Reno, Nevada, 89502, United States
-
Research Medical Center
Kansas City, Missouri, 64132, United States
-
Rhode Island Hospital
Providence, Rhode Island, 02903, United States
-
Riley Hospital for Children
Indianapolis, Indiana, 46202, United States
-
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center
Denver, Colorado, 80218, United States
-
Roswell Park Cancer Institute
Buffalo, New York, 14263, United States
-
Rush MD Anderson Cancer Center
Chicago, Illinois, 60612, United States
-
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital
New Brunswick, New Jersey, 08903, United States
-
SSM Health Good Samaritan
Mount Vernon, Illinois, 62864, United States
-
Saint Catherine Hospital
Garden City, Kansas, 67846, United States
-
Saint Charles Health System
Bend, Oregon, 97701, United States
-
Saint Christopher's Hospital for Children
Philadelphia, Pennsylvania, 19134, United States
-
Saint Francis Cancer Center
Greenville, South Carolina, 29607, United States
-
Saint Francis Hospital
Greenville, South Carolina, 29601, United States
-
Saint John's Hospital
Springfield, Illinois, 62702, United States
-
Saint Joseph's Hospital/Children's Hospital-Tampa
Tampa, Florida, 33607, United States
-
Saint Joseph's Regional Medical Center
Paterson, New Jersey, 07503, United States
-
Saint Jude Children's Research Hospital
Memphis, Tennessee, 38105, United States
-
Saint Luke's Cancer Institute - Boise
Boise, Idaho, 83712, United States
-
Saint Luke's Cancer Institute - Fruitland
Fruitland, Idaho, 83619, United States
-
Saint Luke's Cancer Institute - Meridian
Meridian, Idaho, 83642, United States
-
Saint Luke's Cancer Institute - Nampa
Nampa, Idaho, 83687, United States
-
Saint Luke's Cancer Institute - Twin Falls
Twin Falls, Idaho, 83301, United States
-
Saint Mary's Medical Center
West Palm Beach, Florida, 33407, United States
-
Saint Mary's Regional Medical Center
Reno, Nevada, 89503, United States
-
Saint Peter's University Hospital
New Brunswick, New Jersey, 08901, United States
-
Saint Rose Ambulatory and Surgery Center
Great Bend, Kansas, 67530, United States
-
Salina Regional Health Center
Salina, Kansas, 67401, United States
-
San Jorge Children's Hospital
San Juan, 00912, Puerto Rico
-
Sanford Broadway Medical Center
Fargo, North Dakota, 58122, United States
-
Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota, 57117-5134, United States
-
Scott and White Memorial Hospital
Temple, Texas, 76508, United States
-
Seattle Children's Hospital
Seattle, Washington, 98105, United States
-
Sinai Hospital of Baltimore
Baltimore, Maryland, 21215, United States
-
Siouxland Regional Cancer Center
Sioux City, Iowa, 51101, United States
-
Siteman Cancer Center at West County Hospital
Creve Coeur, Missouri, 63141, United States
-
South Jordan Health Center
South Jordan, Utah, 84009, United States
-
Southern Illinois University School of Medicine
Springfield, Illinois, 62702, United States
-
Springfield Memorial Hospital
Springfield, Illinois, 62781, United States
-
Springfield Regional Cancer Center
Springfield, Ohio, 45504, United States
-
Springfield Regional Medical Center
Springfield, Ohio, 45504, United States
-
Stanford Cancer Institute Palo Alto
Palo Alto, California, 94304, United States
-
State University of New York Upstate Medical University
Syracuse, New York, 13210, United States
-
Straub Clinic and Hospital
Honolulu, Hawaii, 96813, United States
-
Summerlin Hospital Medical Center
Las Vegas, Nevada, 89144, United States
-
Sutter Medical Center Sacramento
Sacramento, California, 95816, United States
-
Swedish Cancer Institute-Issaquah
Issaquah, Washington, 98029, United States
-
Swedish Medical Center-Ballard Campus
Seattle, Washington, 98107, United States
-
Swedish Medical Center-First Hill
Seattle, Washington, 98122, United States
-
T C Thompson Children's Hospital
Chattanooga, Tennessee, 37403, United States
-
Texas Tech University Health Sciences Center-Lubbock
Lubbock, Texas, 79430, United States
-
The Children's Hospital at TriStar Centennial
Nashville, Tennessee, 37203, United States
-
The Kirklin Clinic at Acton Road
Birmingham, Alabama, 35243, United States
-
The Montreal Children's Hospital of the MUHC
Montreal, Quebec, H3H 1P3, Canada
-
The Steven and Alexandra Cohen Children's Medical Center of New York
New Hyde Park, New York, 11040, United States
-
The University of Kansas Cancer Center - Olathe
Olathe, Kansas, 66061, United States
-
The University of Kansas Cancer Center-South
Kansas City, Missouri, 64131, United States
-
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, 19107, United States
-
Trinity Health Grand Rapids Hospital
Grand Rapids, Michigan, 49503, United States
-
Trinity Health Muskegon Hospital
Muskegon, Michigan, 49444, United States
-
UC Comprehensive Cancer Center at Silver Cross
New Lenox, Illinois, 60451, United States
-
UCHealth Memorial Hospital Central
Colorado Springs, Colorado, 80909, United States
-
UCHealth University of Colorado Hospital
Aurora, Colorado, 80045, United States
-
UCLA / Jonsson Comprehensive Cancer Center
Los Angeles, California, 90095, United States
-
UCSF Benioff Children's Hospital Oakland
Oakland, California, 94609, United States
-
UCSF Medical Center-Mission Bay
San Francisco, California, 94158, United States
-
UF Health Cancer Institute - Gainesville
Gainesville, Florida, 32610, United States
-
UHHS-Chagrin Highlands Medical Center
Beachwood, Ohio, 44122, United States
-
UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines, Iowa, 50309, United States
-
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach, Florida, 33442, United States
-
UMC Cancer Center / UMC Health System
Lubbock, Texas, 79415, United States
-
UMass Memorial Medical Center - University Campus
Worcester, Massachusetts, 01655, United States
-
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina, 27599, United States
-
USC / Norris Comprehensive Cancer Center
Los Angeles, California, 90033, United States
-
UT MD Anderson Cancer Center
Houston, Texas, 77030, United States
-
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas, 75390, United States
-
University Pediatric Hospital
San Juan, 00926, Puerto Rico
-
University of Alabama at Birmingham Cancer Center
Birmingham, Alabama, 35233, United States
-
University of California Davis Comprehensive Cancer Center
Sacramento, California, 95817, United States
-
University of Chicago Comprehensive Cancer Center
Chicago, Illinois, 60637, United States
-
University of Illinois
Chicago, Illinois, 60612, United States
-
University of Iowa/Holden Comprehensive Cancer Center
Iowa City, Iowa, 52242, United States
-
University of Kansas Cancer Center
Kansas City, Kansas, 66160, United States
-
University of Kansas Cancer Center - Lee's Summit
Lee's Summit, Missouri, 64064, United States
-
University of Kansas Cancer Center - North
Kansas City, Missouri, 64154, United States
-
University of Kansas Cancer Center-Overland Park
Overland Park, Kansas, 66210, United States
-
University of Kansas Health System Saint Francis Campus
Topeka, Kansas, 66606, United States
-
University of Kansas Hospital-Westwood Cancer Center
Westwood, Kansas, 66205, United States
-
University of Kentucky/Markey Cancer Center
Lexington, Kentucky, 40536, United States
-
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, 33136, United States
-
University of Michigan Health - Sparrow Lansing
Lansing, Michigan, 48912, United States
-
University of Minnesota/Masonic Cancer Center
Minneapolis, Minnesota, 55455, United States
-
University of Mississippi Medical Center
Jackson, Mississippi, 39216, United States
-
University of Missouri Children's Hospital
Columbia, Missouri, 65212, United States
-
University of Nebraska Medical Center
Omaha, Nebraska, 68198, United States
-
University of New Mexico Cancer Center
Albuquerque, New Mexico, 87106, United States
-
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73104, United States
-
University of Rochester
Rochester, New York, 14642, United States
-
University of Texas Health Science Center at San Antonio
San Antonio, Texas, 78229, United States
-
University of Vermont Medical Center
Burlington, Vermont, 05401, United States
-
University of Vermont and State Agricultural College
Burlington, Vermont, 05405, United States
-
University of Virginia Cancer Center
Charlottesville, Virginia, 22908, United States
-
University of Wisconsin Carbone Cancer Center - University Hospital
Madison, Wisconsin, 53792, United States
-
Upper Valley Medical Center
Troy, Ohio, 45373, United States
-
VCU Massey Comprehensive Cancer Center
Richmond, Virginia, 23298, United States
-
Valley Children's Hospital
Madera, California, 93636, United States
-
Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee, 37232, United States
-
Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh, Wisconsin, 54904, United States
-
Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan, Wisconsin, 53081, United States
-
Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers, Wisconsin, 54241, United States
-
Wake Forest University Health Sciences
Winston-Salem, North Carolina, 27157, United States
-
Walter Reed National Military Medical Center
Bethesda, Maryland, 20889-5600, United States
-
Washington University School of Medicine
St Louis, Missouri, 63110, United States
-
Wayne Hospital
Greenville, Ohio, 45331, United States
-
Wayne State University/Karmanos Cancer Institute
Detroit, Michigan, 48201, United States
-
West Michigan Cancer Center
Kalamazoo, Michigan, 49007, United States
-
West Virginia University Charleston Division
Charleston, West Virginia, 25304, United States
-
West Virginia University Healthcare
Morgantown, West Virginia, 26506, United States
-
Wright-Patterson Medical Center
Wright-Patterson Air Force Base, Ohio, 45433, United States
-
Yale University
New Haven, Connecticut, 06520, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a new drug shrink Hard-to-Treat childhood cancers?
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