Can paxlovid be safely used in pregnancy? a new trial investigates

NCT ID NCT05386472

NEW Terminated Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Aug 17, 2026 · Last updated Aug 17, 2026

Summary

This trial is investigating how the COVID-19 treatment Paxlovid (nirmatrelvir/ritonavir) is absorbed and eliminated by the body, and how well it is tolerated, in pregnant women with mild-to-moderate COVID-19. The study will compare these results to those from non-pregnant women with the same condition. Participants will take Paxlovid by mouth every 12 hours for 5 days, and researchers will monitor safety and side effects throughout the study.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: nirmatrelvir/ritonavir (Paxlovid)
What this could lead to: If successful, this could provide crucial safety and dosing data to support using Paxlovid in pregnant women with COVID-19, potentially expanding treatment options for this group.
What could go wrong: This is an early-phase study with a small number of participants, so results may not be conclusive. The safety of the drug during pregnancy is not yet fully established, and there may be risks to the mother or fetus.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

COVID-19

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COVID-19

Contacts and locations

Locations

Beautiful Minds Clinical Research Center

Cutler Bay, Florida, 33157, United States
Boeson Research MSO

Missoula, Montana, 59804, United States
Clinical Research Prime

Idaho Falls, Idaho, 83404, United States
Maximos Ob/Gyn

League City, Texas, 77573, United States
Omega Research Debary

DeBary, Florida, 32713, United States
Omega Research Orlando

Orlando, Florida, 32808, United States
Origin Health

Missoula, Montana, 59804, United States
Santos Research Center

Tampa, Florida, 33615, United States
University of Alabama at Birmingham/Center for Women's Reproductive Health

Birmingham, Alabama, 35233, United States
University of Utah

Salt Lake City, Utah, 84108, United States
University of Utah

Salt Lake City, Utah, 84112, United States
University of Utah Clinical Neuroscience Center

Salt Lake City, Utah, 84132, United States
University of Utah Hospital

Salt Lake City, Utah, 84132, United States

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