New hope for Hard-to-Treat prostate cancer: Immune-Targeting drug combo enters final testing

NCT ID NCT07225946

Recruiting now Disease control Sponsor: Janssen Research & Development, LLC Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 31, 2026 · Updated 3 times

Summary

This Phase 3 trial tests whether adding pasritamig, a drug that directs the body's T-cells to attack prostate cancer cells, to standard chemotherapy (docetaxel) can slow cancer growth better than chemotherapy alone. The study involves 800 men with metastatic castration-resistant prostate cancer, a form that keeps growing despite low testosterone levels. Participants will receive either the combination or docetaxel alone, and researchers will track how long the cancer stays under control.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Pasritamig (a T-cell-redirecting agent) combined with docetaxel chemotherapy
What this could lead to: If successful, this combination could offer a new treatment option that slows cancer progression longer than chemotherapy alone for men with advanced prostate cancer.
What could go wrong: This is an early-stage Phase 3 trial, so results are not yet known. The added drug may cause more side effects, and not all participants may benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

castration-resistant prostate carcinoma metastatic prostate carcinoma Prostatic Neoplasms, Castration-Resistant

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PROSTATIC NEOPLASMS, CASTRATION-RESISTANT

Contacts and locations

Locations

ASL Napoli 2 Nord-SM delle Grazie Hospital
RECRUITING

Localita La Schiana Pozzuoli, 80078, Italy
AZ Maria Middelares
RECRUITING

Ghent, 9000, Belgium
AZORG campus Aalst Moorselbaan
RECRUITING

Aalst, 9300, Belgium
Adana City Hospital
RECRUITING

Adana, 01170, Turkey (Türkiye)
Ankara University Medical Faculty
RECRUITING

Ankara, 06100, Turkey (Türkiye)
Arizona Clinical Trials
RECRUITING

Chandler, Arizona, 85225, United States
Arkansas Urology
RECRUITING

Little Rock, Arkansas, 72211, United States
Asan Medical Center
RECRUITING

Seoul, 05505, South Korea
Astera Cancer Care
RECRUITING

East Brunswick, New Jersey, 08816, United States
Avera Medical Group
RECRUITING

Sioux Falls, South Dakota, 57105, United States
Azienda Ospedaliera Universitaria Citta della Salute e della Scienza di Torino
RECRUITING

Torino, 10126, Italy
Azienda Ospedaliero Universitaria Careggi
RECRUITING

Florence, 50134, Italy
Beatson West Of Scotland Cancer Centre
RECRUITING

Glasgow, G12 0YN, United Kingdom
Beijing Cancer Hospital
RECRUITING

Beijing, 100142, China
Beijing Luhe Hospital, Capital Medical University
RECRUITING

Beijing, 101100, China
British Columbia Cancer Agency
RECRUITING

Vancouver, British Columbia, V5Z4E6, Canada
British Columbia Cancer Agency Vancouver Island Centre
RECRUITING

Victoria, British Columbia, V8R 6V5, Canada
CEPHO Centro de Estudos e Pesquisa de Hematologia e Oncologia
RECRUITING

Santo André, 09060 870, Brazil
CHC MontLegia
RECRUITING

Liège, 4000, Belgium
CHU de Quebec Universite Laval
RECRUITING

Québec, Quebec, G1R 2J6, Canada
Cancer Center of Kansas Heritage Plaza Medical Building
RECRUITING

Wichita, Kansas, 67214, United States
Cancer and Blood Specialty Clinic
RECRUITING

Los Alamitos, California, 90720, United States
Carolina Urologic Research Center
RECRUITING

Myrtle Beach, South Carolina, 29572, United States
Centre Eugene Marquis
RECRUITING

Rennes, 35062, France
Centre Jean Perrin
RECRUITING

Clermont-Ferrand, 63011, France
Centre Leon Berard
RECRUITING

Lyon, 69008, France
Centre Oscar Lambret
RECRUITING

Lille, 59000, France
Centre de Recherche du CHUM
RECRUITING

Montreal, Quebec, H2X 0A9, Canada
Chesapeake Urology Research Associates
RECRUITING

Towson, Maryland, 21204, United States
China Medical University Hospital
RECRUITING

Taichung, 404, Taiwan
Chongqing University Cancer Hospital
RECRUITING

Chongqing, 400030, China
Chu Helora Hospital La Louviere Site Jolimont
RECRUITING

La Louvière, 7100, Belgium
Colorado Clinical Research
RECRUITING

Lakewood, Colorado, 80228, United States
Duly Health and Care
RECRUITING

Lisle, Illinois, 60532, United States
ESHO Empresa De Servicos Hospitalares S A
RECRUITING

São Paulo, 01232 010, Brazil
East Jefferson General Hospital
RECRUITING

Metairie, Louisiana, 70006, United States
Florida Cancer Specialists
RECRUITING

Sarasota, Florida, 34232, United States
Fred Hutch Cancer Center Sloan Clinic 2
RECRUITING

Seattle, Washington, 98109, United States
Fred Hutchinson Cancer Research Center
RECRUITING

Seattle, Washington, 98109, United States
Grand Valley Oncology
RECRUITING

Grand Junction, Colorado, 81505, United States
Groupe Hospitalo-Universitaire Carémeau
RECRUITING

Nîmes, 30900, France
Gulhane Training and Research Hospital
RECRUITING

Ankara, 06010, Turkey (Türkiye)
Gustave Roussy
RECRUITING

Villejuif, 94800, France
HealthPartners Cancer Center at Regions Hospital CRC East
RECRUITING

Saint Paul, Minnesota, 55101, United States
HealthPartners Frauenshuh Cancer Center CRC West
RECRUITING

Saint Louis Park, Minnesota, 55426, United States
Hopital Europeen Georges-Pompidou
RECRUITING

Paris, 75908, France
Hosp. Clinico Univ. Lozano Blesa
RECRUITING

Zaragoza, 50009, Spain
Hosp. Gral. Univ. J.M. Morales Meseguer
RECRUITING

Murcia, 30008, Spain
Hosp. Gral. Univ. Valencia
RECRUITING

Valencia, 46014, Spain
Hosp. Univ. 12 de Octubre
RECRUITING

Madrid, 28041, Spain
Hosp. Univ. Germans Trias I Pujol
RECRUITING

Badalona, 08916, Spain
Hosp. Univ. Ramon Y Cajal
RECRUITING

Madrid, 28034, Spain
Hosp. Virgen Macarena
RECRUITING

Seville, 41009, Spain
Hospital Ana Nery Santa Cruz do Sul
RECRUITING

Santa Cruz do Sul, 96835-100, Brazil
Hospital Kuala Lumpur
RECRUITING

Kuala Lumpur, 50586, Malaysia
Hospital Umum Sarawak
RECRUITING

Kuching, 93586, Malaysia
Hospital Wanita dan Kanak-Kanak Sabah
RECRUITING

Kota Kinabalu, 88996, Malaysia
Houston Metro Urology
RECRUITING

Houston, Texas, 77027, United States
Huashan Hospital Fudan University
RECRUITING

Shanghai, 200031, China
IRCCS Ospedale San Raffaele
RECRUITING

Milan, 20132, Italy
Icon Cancer Centre Kurralta Park
RECRUITING

Kurralta Park, 5037, Australia
Institut Bergonie
RECRUITING

Bordeaux, 33076, France
Istanbul University Cerrahpasa tip Fakultesi
RECRUITING

Istanbul, 34096, Turkey (Türkiye)
Istituto Europeo di Oncologia
RECRUITING

Milan, 20141, Italy
Istituto Nazionale Tumori Regina Elena
RECRUITING

Roma, 00144, Italy
Johns Hopkins Hospital
RECRUITING

Baltimore, Maryland, 21287, United States
Johns Hopkins Medical Institutions
RECRUITING

Baltimore, Maryland, 21287, United States
Juntendo University Hospital
RECRUITING

Bunkyō City, 113 8431, Japan
Kaiser Permanente Southern California
RECRUITING

Riverside, California, 92505, United States
Kanazawa University Hospital
RECRUITING

Kanazawa, 920 8641, Japan
Kansai Medical University Hospital
RECRUITING

Hirakata, 573-1191, Japan
Kitasato University Hospital
RECRUITING

Sagamihara, 252-0375, Japan
Klinikum rechts der Isar an der Technischen Universitat Munchen
RECRUITING

München, 81675, Germany
Kobe University Hospital
RECRUITING

Kobe, 650 0017, Japan
Koc Universitesi Hastanesi
RECRUITING

Istanbul, 34147, Turkey (Türkiye)
Lancashire Teaching Hospitals NHS Foundation Trust Royal Preston Hospital
RECRUITING

Preston, PR2 9HT, United Kingdom
Laura & Isaac Perlmutter Cancer Center at NYU Langone Hospital - Long Island
RECRUITING

Mineola, New York, 11501, United States
Lehigh Valley Hospital
RECRUITING

Allentown, Pennsylvania, 18103, United States
Liga Norte Riograndense Contra O Cancer
RECRUITING

Natal, 59062 000, Brazil
Linkou Chang Gung Memorial Hospital
RECRUITING

Taoyuan, 333, Taiwan
Martini-Klinik am Universitätsklinikum Hamburg-Eppendorf Urologie
RECRUITING

Hamburg, 20246, Germany
Medicana International Izmir
RECRUITING

Izmir, 35170, Turkey (Türkiye)
MemorialCare Orange Coast Medical Center
RECRUITING

Fountain Valley, California, 92708, United States
MidLantic Urology
RECRUITING

Bala-Cynwyd, Pennsylvania, 19004, United States
Montefiore Medical Center
RECRUITING

The Bronx, New York, 10461, United States
NAIC Nair Antunes Instituto do Cancer
RECRUITING

Bauru, 17033-495, Brazil
NHO Revive Research Institute, LLC
RECRUITING

Lincoln, Nebraska, 68506, United States
NYU Langone Health Laura and Isaac Perlmutter Cancer Center
RECRUITING

New York, New York, 10016, United States
Nanjing Drum Tower Hospital
RECRUITING

Nanjing, 210009, China
National Cancer Center
RECRUITING

Goyang-si, 10408, South Korea
National Cheng Kung University Hospital
RECRUITING

Tainan, 704, Taiwan
Norton Cancer Institute
RECRUITING

Louisville, Kentucky, 40207, United States
Oregon Urology Institute
RECRUITING

Springfield, Oregon, 97477, United States
Pan American Center for Oncology Trials LLC
RECRUITING

San Juan, 935, Puerto Rico
Pantai Hospital Kuala Lumpur
RECRUITING

Kuala Lumpur, 59100, Malaysia
Penn State Milton S. Hershey Medical Center
RECRUITING

Hershey, Pennsylvania, 17033, United States
Peter MacCallum Cancer Centre
RECRUITING

Melbourne, 3000, Australia
Princess Alexandra Hospital
RECRUITING

Woolloongabba, 4102, Australia
Princess Margaret Cancer Centre
RECRUITING

Toronto, Ontario, M5G 2C4, Canada
Profound Research LLC at Cancer and Leukemia Center
RECRUITING

Sterling Heights, Michigan, 48314, United States
Providence Saint John s Health Center
RECRUITING

Santa Monica, California, 90404, United States
Rocky Mountain Cancer Centers
RECRUITING

Aurora, Colorado, 80012, United States
Royal Marsden Hospital
RECRUITING

Sutton, SM2 5PT, United Kingdom
Rutgers Cancer Institute of New Jersey
RECRUITING

New Brunswick, New Jersey, 08901, United States
Samsung Medical Center
RECRUITING

Seoul, 06351, South Korea
Severance Hospital Yonsei University Health System
RECRUITING

Seoul, 03722, South Korea
Shanghai General Hospital
RECRUITING

Shanghai, 200080, China
Sharp Center for Research
RECRUITING

San Diego, California, 92123, United States
Shizuoka Cancer Center
RECRUITING

Sunto Gun, 411 8777, Japan
Sir Run Run Shaw Hospital Zhejiang University School of Medicine
RECRUITING

Hangzhou, 310009, China
St Bartholomews Hospital
RECRUITING

London, EC1A 7BE, United Kingdom
St Elizabeth Healthcare
RECRUITING

Edgewood, Kentucky, 41017, United States
Studienpraxis Urologie Drs. Feyerabend
RECRUITING

Nürtingen, 72622, Germany
Sun Yat Sen University Cancer Center
RECRUITING

Guangzhou, 510060, China
Sydney Adventist Hospital
RECRUITING

Wahroonga, 2076, Australia
Taichung Veterans General Hospital
RECRUITING

Taichung, 407219, Taiwan
Tennessee Cancer Specialists
RECRUITING

Knoxville, Tennessee, 37909, United States
Texas Oncology
RECRUITING

Austin, Texas, 78731, United States
Texas Oncology 1
RECRUITING

Sugar Land, Texas, 77479, United States
The Catholic University of Korea Seoul St Marys Hospital
RECRUITING

Seoul, 06591, South Korea
The Central Hospital of Wuhan
RECRUITING

Wuhan, 430014, China
The First Affiliated Hospital of Guangzhou Medical University
RECRUITING

Guangzhou, 510120, China
The First Affiliated Hospital of Xian Jiaotong University
RECRUITING

Xi'an, 710061, China
The Newcastle upon Tyne Hospitals NHS Trust - Freeman Hospit
RECRUITING

Newcastle upon Tyne, NE7 7DN, United Kingdom
The Ottawa Hospital Cancer Centre
RECRUITING

Ottawa, Ontario, K1H 8L6, Canada
The Royal Marsden NHS Trust
RECRUITING

London, SW3 6JJ, United Kingdom
The Second Hospital Of Tianjin Medical University
RECRUITING

Tianjin, 300211, China
The Third People's Hospital of Chengdu
RECRUITING

Chengdu, 610014, China
Tungs' Taichung MetroHarbor Hospital
RECRUITING

Taichung, 435, Taiwan
USC Norris Comprehensive Cancer Center
RECRUITING

Los Angeles, California, 90033, United States
UT Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
Universitaetsklinikum Essen
RECRUITING

Essen, 45147, Germany
Universitatsklinikum Carl Gustav Carus Dresden
RECRUITING

Dresden, 01307, Germany
University Malaya Medical Centre
RECRUITING

Kuala Lumpur, 59100, Malaysia
University Of California San Diego
RECRUITING

La Jolla, California, 92037, United States
University Of Pittsburgh Medical Center UPMC Hillman Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
University of Cincinnati
RECRUITING

Cincinnati, Ohio, 45219, United States
University of Maryland
RECRUITING

Baltimore, Maryland, 21201, United States
Urologicum Duisburg
RECRUITING

Duisburg, 47169, Germany
Vail Health Shaw Cancer Center
RECRUITING

Edwards, Colorado, 81632, United States
Valkyrie Clinical Trials
RECRUITING

Los Angeles, California, 90067, United States
Velindre Cancer Centre
RECRUITING

Cardiff, CF14 2TL, United Kingdom
Virginia Cancer Specialists
RECRUITING

Fairfax, Virginia, 22031, United States
Warringal Private Hospital
RECRUITING

Heidelberg, 3084, Australia
Washington University
RECRUITING

St Louis, Missouri, 63110, United States
West China Hospital Sichuan University
RECRUITING

Chengdu, 610041, China
Winship Cancer Institute Emory University
RECRUITING

Atlanta, Georgia, 30322, United States
Xinhua hospital,Shanghai Jiaotong University
RECRUITING

Shanghai, 200082, China
Yokohama City University Medical Center
RECRUITING

Yokohama, 232 0024, Japan
ZAS Augustinus
RECRUITING

Antwerp, 2610, Belgium

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