New drug aims to put the brakes on genetic form of Parkinson's

NCT ID NCT05819359

Ongoing Disease control Sponsor: Bial R&D Investments, S.A. Source: ClinicalTrials.gov ↗

Summary

This study is testing whether an investigational drug called BIA 28-6156 can slow the worsening of movement problems in people with Parkinson's disease who have a specific genetic change in the GBA1 gene. About 237 participants will take either the drug at one of two doses or a placebo pill for 78 weeks, while continuing their standard Parkinson's medications. The main goal is to see if the drug can delay meaningful progression in daily motor tasks and physical movement.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

A.O.U. San Giovanni di Dio Ruggi d'Aragona Centro Parkinson- Piano Rialzato Corpo QT

Salerno, 84125, Italy
Amsterdam Medical Center UMC

Amsterdam, Netherlands
Assistance Publique-Hopitaux de Paris (AP-HP) - Hopital Pitie-Salpetriere - Centres d'Investigation Clinique (CIC) Paris-Est

Paris, France
Barrow Neurological Institute

Phoenix, Arizona, 85013, United States
Baylor College of Medicine

Houston, Texas, 77030, United States
Baylor University Medical Center

Baltimore, Maryland, 21287, United States
Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02115, United States
CHU de Nantes - Hopital Nord Laennec

Nantes, France
CHU de Nice Hopital Pasteur

Nice, 6002, France
CHU de Nimes

Nîmes, France
CHU de Rennes Hopital Pontchaillou

Rennes, France
CIC Toulouse

Toulouse, France
CNS - Campus Neurologico

Torres Vedras, Portugal
Cedars-Sinai

Los Angeles, California, 90048, United States
Centro Hospitalar Universitario de Coimbra

Coimbra, Portugal
Centro Hospitalar Universitario de Santo Antonio

Porto, 4099-001, Portugal
Centrum Medyczne NEUROMED Sp. z o.o. ul.

Bydgoszcz, 85-163, Poland
Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States
Clinique Neuro-Outaouais (Neuro-Outaouais Clinic)

Gatineau, Quebec, Canada
Columbia University Medical Center

New York, New York, 10032, United States
Evergreen Neuroscience Institute

Kirkland, Washington, 98034, United States
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico

Milan, 20122, Italy
Gertrudis Clinic Biskirchen, Parkinson-Center

Biskirchen, 35638, Germany
Glasgow Memory Clinic

Glasgow, United Kingdom
Hopital Paule de Viguier

Toulouse, France
Hospital Ruber Internacional

Madrid, 28034, Spain
Hospital S.JOÃO

Porto, 4200-319, Portugal
Hospital Senhora da Oliveira de Guimaraes

Guimarães, 4835-044, Portugal
Hospital Universitaio de La Princesa

Madrid, 28006, Spain
Hospital Universitari Germans Trias i Pujol

Badalona, 08916, Spain
Hospital Universitario Cruces

Barakaldo, 48903, Spain
Hospital Universitario Virgen del Rocio

Seville, 41013, Spain
Hospital Vall D´Hebron

Barcelona, 08035, Spain
Hospital de la Santa Creu I Sant Pau

Barcelona, 08025, Spain
IRCCS Carlo Besta Neurological Institute

Milan, 20133, Italy
IRCCS Istituto Delle Scienze Neurologiche DI

Bologna, Italy
IRCSS San Raffaele Pisana

Roma, 163, Italy
Icahn School of Medicine at Mount Sinai Beth Israel

New York, New York, 10003, United States
Inland Northwest Research

Spokane, Washington, 99202, United States
Intermountain Healthcare

Salt Lake City, Utah, 84107, United States
Istituto Clinico Humanitas

Rozzano, 20086, Italy
King's College London - David Goldberg Centre

London, United Kingdom
Klinikum der Universität München, Campus Grosshadern, Neurologische Klinik und Poliklinik

Munich, 81377, Germany
Krakowkska Akademia Neurologii Sp. z o.o

Krakow, 31-505, Poland
Ludwig-Maximilians University Munich

Munich, Germany
MUSC

Charleston, South Carolina, 29425, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Mayo Clinic

Rochester, Minnesota, 55905, United States
Montreal Neurological Institute & Hospital

Montreal, Quebec, 3801, Canada
Morehouse School of Medicine

Atlanta, Georgia, 30310, United States
NHS Tayside-Ninewells Hospital and Medical School

Dundee, United Kingdom
NeuroKlinika Gabinet Lekarski

Lodz, 90-640, Poland
Neurologisches Fachkrankenhaus für, Bewegungsstörungen und Parkinson

Beelitz-Heilstätten, 14547, Germany
Neurologmottagningen, QD 62

Uppsala, Sweden
Northwell Health

New York, New York, 10075, United States
Northwell Health Physician Partners

New York, New York, 10075-1851, United States
Northwestern University

Chicago, Illinois, 60611, United States
Oregon Health and Science University

Portland, Oregon, 97239, United States
Ospedale Antonio Perrino

Brindisi, 72100, Italy
Ottawa Hospital Research Institute

Ottawa, Canada
Paracelsus-Elena-Klinik

Kassel, 34128, Germany
Park Nicollet Struther's Parkinson's Center (Struthers Parkinsons Center at HealthPartners)

Saint Paul, Minnesota, 55427, United States
Parkinson's Center and Movement Disorders of Boca Raton

Boca Raton, Florida, 33486, United States
Parkinson's Disease and Movement Disorders Cente at University of Pennyslvania

Philadelphia, Pennsylvania, 19107, United States
Parkinson-Klinik Ortenau GmbH&Co KG

Wolfach, 77709, Germany
Quest Research Institute, LLC

Farmington Hills, Michigan, 48334, United States
Renstar Medical Research

Ocala, Florida, 34470, United States
Robert Wood Johnson Medical School

New Brunswick, New Jersey, 08901, United States
Rush University Medical Center

Chicago, Illinois, 60612, United States
Skane University Hospital, Lund University

Lund, 221 85, Sweden
Spedali Civilia di Brescia

Brescia, 25123, Italy
St. Antonius Ziekenhuis (St. Antonius Hospital) - Utrecht

Utrecht, Netherlands
Struthers Parkinson's Center- East

Saint Paul, Minnesota, 55130, United States
The Johns Hopkins University School of Medicine

Baltimore, Maryland, 21287, United States
The Newcastle upon Tyne Hospitals NHS Foundation Trust, Freeman Hospital

Newcastle upon Tyne, United Kingdom
Thomas Jefferson University

Philadelphia, Pennsylvania, 19107, United States
Univerity of Toledo

Toledo, Ohio, 43614, United States
Universita degli Studi della Campania Luigi Vanvitelli - Clinica Neurologia I

Naples, 80138, Italy
Universita degli Studi di Padova - Azienda Ospedaliera di Padova - Clinica Neurologica

Padua, 35128, Italy
Universitats klinikum Marburg

Marburg, 35039, Germany
University Hospitals Cleveland Medical Center

South Euclid, Ohio, 44121, United States
University Hospitals Plymouth NHS Trust

Plymouth, United Kingdom
University Medical Center Groningen

Groningen, Netherlands
University of California San Diego

La Jolla, California, 92037, United States
University of Colorado

Aurora, Colorado, 80045, United States
University of Iowa Hospitals and Clinics

Iowa City, Iowa, 52242, United States
University of Kansas Medical Center

Kansas City, Kansas, 66103, United States
University of Kentucky

Lexington, Kentucky, 40536, United States
University of Maryland Medical Center

Baltimore, Maryland, 21201, United States
University of Miami, Dept. of Neurology

Miami, Florida, 33136, United States
University of Rochester Neurology

Rochester, New York, 14642, United States
University of Texas Health Science Center - San Antonio

San Antonio, Texas, 78229, United States
University of Washington

Seattle, Washington, 98195, United States
Vanderbilt Medical Center

Nashville, Tennessee, 37232, United States
Weil Cornell Medical Center

New York, New York, 10021, United States

Conditions

Explore the condition pages connected to this study.

PARKINSON'S DISEASE