New immunotherapy cocktail takes on tough pancreatic cancer

NCT ID NCT04390399

First seen Nov 01, 2025 · Last updated Apr 29, 2026 · Updated 22 times

Summary

This study tests whether adding a combination of immunotherapy drugs (aldoxorubicin, N-803, and PD-L1 t-haNK) to standard chemotherapy can help people with advanced pancreatic cancer live longer without their disease getting worse. About 328 adults with locally advanced or metastatic pancreatic cancer will be split into groups based on their treatment history. The goal is to see if the new combo improves progression-free survival, overall survival, and quality of life compared to chemotherapy alone.

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Contacts and locations

Locations

  • Astera Cancer Care

    East Brunswick, New Jersey, 08816, United States

  • Avera Cancer Institute

    Sioux Falls, South Dakota, 57105, United States

  • Chan Soon-Shiong Institute for Medicine

    El Segundo, California, 90245, United States

  • Hoag memorial Presbyterian Hospital

    Newport Beach, California, 92663, United States

Conditions

Explore the condition pages connected to this study.