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New drug combo shows promise for advanced breast cancer

NCT ID NCT02668666

Completed Disease control Sponsor: Oana Danciu, MD Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a combination of two drugs, palbociclib and tamoxifen, as the first treatment for people with a certain type of advanced breast cancer (HR-positive, HER2-negative). The goal was to see how long the cancer could be kept from growing. 49 participants took both pills daily. The study found that this combination may help control the disease, but it is not a cure, and ongoing treatment is needed.

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Conditions

The condition(s) this trial relates to.

breast cancer breast carcinoma breast neoplasm estrogen-receptor positive breast cancer Her2-receptor negative breast cancer hormone receptor-positive breast cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ESTROGEN RECEPTOR-POSITIVE BREAST CANCER HORMONE RECEPTOR POSITIVE MALIGNANT NEOPLASM OF BREAST HUMAN EPIDERMAL GROWTH FACTOR 2 NEGATIVE CARCINOMA OF BREAST METASTATIC BREAST CANCER PROGESTERONE RECEPTOR POSITIVE TUMOR

Contacts and locations

Locations

  • Michigan State University

    Lansing, Michigan, 48910, United States

  • Penn State Cancer Institute

    Hershey, Pennsylvania, 17033, United States

  • ProHealth Care

    Waukesha, Wisconsin, 53188, United States

  • University of Illinois Cancer Center

    Chicago, Illinois, 60612, United States

  • University of Minnesota

    Minneapolis, Minnesota, 55455, United States

  • University of Nebraska Medical Center

    Omaha, Nebraska, 68198, United States

  • University of Wisconsin

    Madison, Wisconsin, 53705, United States