Can we wake and kill sleeping breast cancer cells before they return?
NCT ID NCT04841148
First seen Apr 14, 2026 · Last updated May 16, 2026 · Updated 7 times
Summary
This study is for people with early-stage ER+ breast cancer who still have dormant (sleeping) cancer cells in their bone marrow after surgery and standard therapy. Researchers will test two drugs—avelumab (an immunotherapy) and hydroxychloroquine—alone or combined with palbociclib, to see if they can clear these hidden cells and lower the risk of cancer coming back. About 96 participants will be enrolled to check safety and early effectiveness.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Dana-Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02215, United States
Contact Email: •••••@•••••
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Georgetown University
RECRUITINGWashington D.C., District of Columbia, 20007, United States
Contact Email: •••••@•••••
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Indiana University
RECRUITINGIndianapolis, Indiana, 46202, United States
Contact Email: •••••@•••••
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University of Chicago
RECRUITINGChicago, Illinois, 60637, United States
Contact Email: •••••@•••••
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University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Washington
RECRUITINGSeattle, Washington, 98195, United States
Contact Email: •••••@•••••
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Vanderbilt University
RECRUITINGNashville, Tennessee, 37232, United States
Contact Email: •••••@•••••
Conditions
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