New drug mix may ease post-amputation pain in sarcoma patients
NCT ID NCT07276867
First seen Jan 07, 2026 · Last updated Jun 23, 2026 · Updated 24 times
Summary
This study compares two spinal anesthesia methods for people having a leg amputated above the knee because of sarcoma (a type of bone cancer). One group gets the standard painkiller fentanyl plus a drug called dexmedetomidine, while the other gets fentanyl alone. The goal is to see if the combination provides longer-lasting pain relief after surgery. The trial will enroll 58 adults aged 18 to 60.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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National Cancer Institute
RECRUITINGCairo, 11796, Egypt
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Dexmedetomidine and fentanyl
What this could lead to
If it works, this could point toward a better way to manage pain after leg amputation surgery.
What could go wrong
This is a small, early-stage study with only 58 participants, so results may not apply to everyone. There is also a risk of side effects from the added medication.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.