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Why do some shoulder injections work better? a study looks for clues in pain type

NCT ID NCT07792421

Knowledge-focused Sponsor: Vejle Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 28, 2026 · Last updated Sep 03, 2026 · Updated 2 times

Summary

This study follows 134 adults with subacromial pain syndrome, a common cause of shoulder pain. All receive a routine corticosteroid injection into the shoulder as part of usual care. Researchers test whether people with a nociplastic pain phenotype, a type of pain processing that is not purely tissue-based, experience a different change in pain four weeks after the injection compared to those without this phenotype. The goal is to see if a simple pain assessment can help predict who benefits most from this standard treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Corticosteroid injection into the shoulder, given as part of routine care
What this could lead to
If pain phenotype predicts response, doctors could tailor shoulder pain treatment, offering injections to those most likely to benefit and alternatives to others.
What could go wrong
This observational study does not test a new treatment; it only looks for a link. The results may not apply to all patients, and the injection itself carries typical risks like temporary pain or infection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 134 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Nov 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients referred to and evaluated at the specialised shoulder clinic at Vejle Hospital, Denmark

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Diagnosed with SAPS (dm751, dm753, dm754, dm755 2. Shoulder pain ≥ 3 months 3. ≥ 3 out of 5 specific shoulder test 4. Age 18-70 years 5. Increased pain during active arm elevation 6. Pain during active elevation ≥ 3 (VAS) 7. Receving a corticosteroid injection based on routine clinical proctice Exclusion Criteria: 1. Severe visual impairment 2. Epilepsy 3. Severe cognitive or physical impairment 4. Language barrier (Danish) 5. Receving a corticosteroid injection at a site other than the subacromial bursa (e.g. acromioclavicular joint or intra-articular injection)

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Conditions

The condition(s) this trial relates to.

Chronic Pain Musculoskeletal Pain Nociplastic Pain rotator cuff syndrome shoulder impingement syndrome Shoulder Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Rotator cuff related shoulder pain SAPS Shoulder impingement syndrome Shoulder pain Subacromial pain syndrome

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Vejle Hospital

    Vejle, Denmark

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