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Breath of fresh air: new ventilator weaning method could cut ICU stays

NCT ID NCT07709182

Disease control Sponsor: Tanta University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 16, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This trial compares two methods for weaning patients off mechanical ventilators in the ICU. One method uses standard pressure support, while the other adjusts support based on a measure called airway occlusion pressure (P0.1). The goal is to see which approach leads to more days free from the ventilator and shorter ICU stays. Participants are adults who are stable enough to begin the weaning process.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
airway occlusion pressure (P0.1)-guided pressure support ventilation
What this could lead to
If successful, this approach could help ICU patients come off ventilators faster, reducing complications and hospital stays.
What could go wrong
This is a small, early-stage trial, so results may not apply broadly. The technique requires specific equipment and expertise.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

Jan 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Mechanically ventilated adult patients ≥ 21 years. * Patients on pressure support ventilation for at least 24 hours and clinically determined to be in the weaning window (transition between assisted ventilation and spontaneous ventilation) with improving respiratory status. * Hemodynamically stable \[mean arterial pressure (MAP) ≥60 mmHg\]. * All patients will be required to have light sedation with a Richmond Agitation-Sedation Scale (RASS) score between -1 and 0 to allow reliable assessment of respiratory drive. Exclusion Criteria: * Patients with neuromuscular disorders affecting respiratory drive * Glasgow Coma Scale (GCS) score below 8 * Cervical spinal cord injury * Receipt of neuromuscular blockers within the previous 24 hours * Morbid obesity resulting in unreliable respiratory mechanics * Pregnancy * Deep sedation defined as RASS ≤ -2 * Hemodynamic instability requiring escalating vasopressor support.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Airway occlusion pressure Conventional management Pressure support ventilation Weaning window patients

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Tanta University

    RECRUITING

    Tanta, Al Gharbia, 31527, Egypt

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