Can Ozone-Infused blood ease sleeplessness after a stroke?
NCT ID NCT05508113
First seen Sep 04, 2026 · Last updated Sep 04, 2026
Summary
This trial tests whether ozone autohemotherapy, a procedure where a person's blood is mixed with ozone and put back into their body, can improve sleep in people who have insomnia after an ischemic stroke. Researchers will measure sleep quality and look at blood markers of inflammation and brain chemicals to see if the therapy helps and how it might work. The study includes adults who had an ischemic stroke and report poor sleep.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- ozone autohemotherapy
- What this could lead to
- If it works, this could offer a new way to ease insomnia in stroke survivors, potentially improving their recovery and quality of life.
- What could go wrong
- This is a small, early-stage trial, so the treatment may not prove effective or safe. Ozone therapy carries risks like infection or allergic reactions, and its benefits for sleep are not yet established.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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65 people
The number who actually took part.
- Started
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Aug 2022
- Finished
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Jun 2024
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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Children (under 18), adults (18 to 64) and older adults (65 and over)
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
The inclusion criteria were as follows: (1) age ≥18 years old; (2) diagnosis of ischemic stroke by cranial CT or MRI and other related imaging examinations; (3) Insomnia Severity Index (ISI) score \> 7 points; (4) post-ischemic stroke insomnia; (5) sufficient cognitive function and communication ability to provide informed consent and perform the study protocol. The exclusion criteria were as follows: (1) G6PHD (glucose 6 phosphate dehydrogenase) deficiency; (2) pregnancy; (3) toxic diffuse goiter; (4) severe coagulation disorder; (5) the use of psychotropic medications (hypnotics, benzodiazepine, benzodiazepine agonists, antidepressants, or antipsychotics) for sleep.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Huikang Hospital in Dehui city
Dehui, Jilin, 130021, China
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the Second Hospital of Jilin University
Changchun, Jilin, 130021, China