Hope for PSP: experimental drug AMX0035 tested in major trial

NCT ID NCT06122662

NEW Completed Disease control Sponsor: Amylyx Pharmaceuticals Inc. Source: ClinicalTrials.gov ↗

First seen May 01, 2026 · Last updated May 01, 2026

Summary

This study tested an experimental drug called AMX0035 in 139 people with progressive supranuclear palsy (PSP), a rare brain disease that affects movement and balance. The goal was to see if the drug could slow down the disease. Participants received either the drug or a placebo, and researchers measured changes in symptoms over time. The study is now complete, and results will help determine if AMX0035 is safe and effective for PSP.

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Contacts and locations

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Locations

Asklepios Fachklinikum Stadtroda

Stadtroda, Thuringia, 7646, Germany
Augusta University

Augusta, Georgia, 30912, United States
Azienda Ospedale-Università di Padova

Padova, 35128, Italy
Azienda Ospedaliera Universitaria OO. RR. S. Giovanni di Dio e Ruggi D'Aragona

Salerno, 84131, Italy
Azienda Ospedaliera Universitaria Policlinico Umberto I - Università di Roma La Sapienza

Roma, 185, Italy
Baylor College of Medicine

Houston, Texas, 77030, United States
CHU Rennes - Hopital Pontchaillou

Rennes, Ille Et Vilaine, 35033, France
CHU de Limoges - Hôpital Dupuytren

Limoges, Haute Vienne, 87042, France
Cedars Sinai Medical Center

Los Angeles, California, 90048, United States
Central Texas Neurology Consultants

Round Rock, Texas, 78681, United States
Cleveland Clinic Lou Ruvo Center for Brain Health

Las Vegas, Nevada, 89106, United States
Clinica Universidad de Navarra

Pamplona, Navarre, 31008, Spain
Fondazione IRCCS CA' Granda Ospedale Maggiore Policlinico

Milan, 20122, Italy
Fondazione IRCCS Istituto Neurologico Carlo Besta

Milan, 20133, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Roma, 168, Italy
Groupe Hospitalier Pellegrin - Hôpital Pellegrin

Bordeaux, Gironde, 30076, France
Groupe Hospitalier Pitie-Salpetriere

Paris, 75013, France
Hopital Caremeau

Nîmes, Gard, 30029, France
Hopital Roger Salengro - CHU Lille

Lille, Nord, 59037, France
Hospital Clinic de Barcelona

Barcelona, 8036, Spain
Hospital Universitari i Politecnic La Fe

Valencia, València, 46026, Spain
Hospital Universitario Ramon y Cajal

Madrid, 28034, Spain
Hospital Universitario Virgen del Rocio

Seville, 41013, Spain
Hospital Universitario de La Princesa

Madrid, 28006, Spain
Hospital de Cruces

Barakaldo, Bizkaia, 48903, Spain
Hôpital de la Timone

Marseille, Bouches-du-Rhône, 13385, France
Kerwin Medical Center

Dallas, Texas, 75231, United States
Klinikum der Universität München

Munich, Bavaria, Germany
Krankenhaus Agatharied

Hausham, Bavaria, 83734, Germany
Lahey Hospital and Medical Center

Burlington, Massachusetts, 01805, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Mayo Clinic

Scottsdale, Arizona, 85259, United States
Mayo Clinic - Rochester

Rochester, Missouri, 55905, United States
Mayo Clinic Florida

Jacksonville, Florida, 32224, United States
Medical University of South Carolina (MUSC)

Charleston, South Carolina, 29425, United States
Northwestern University PD and Movement Disorders Center

Chicago, Illinois, 60611, United States
Ochsner Medical Center

New Orleans, Louisiana, 70121, United States
Oregon Health & Science University

Portland, Oregon, 97239, United States
Paracelsus-Elena-Klinik Kassel

Kassel, Hesse, 34128, Germany
Parkinson's & Movement Disorder Institute

Fountain Valley, California, 92708, United States
Parkinson's Disease and Movement Disorders Center of Boca Raton

Boca Raton, Florida, 33486, United States
Parkinsons and Movement Disorder Center at the Queens Medical Center

Honolulu, Hawaii, 96813, United States
Pennsylvania Hospital

Philadelphia, Pennsylvania, 19107, United States
Quest Research Institute

Farmington Hills, Michigan, 48334, United States
Stanford Movement Disorder Center

Palo Alto, California, 94304, United States
The Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States
UC Health Anschutz Outpatient Pavilion Anschutz Medical Campus

Aurora, Colorado, 80045, United States
UF Health Dorothy Mangurian Neuroimaging Suite

Gainesville, Florida, 32608, United States
Universitaetsklinikum Carl Gustav Carus TU Dresden

Dresden, Saxony, 1307, Germany
Universitaetsklinikum Duesseldorf AoeR

Ulm, Baden-Wurttemberg, 89081, Germany
Universitaetsklinikum Ulm

Ulm, Baden-Wurttemberg, 89081, Germany
University of Arkansas for Medical Sciences

Little Rock, Arkansas, 72205, United States
University of California, San Francisco (UCSF)

San Francisco, California, 94158, United States
University of Cincinnati

Cincinnati, Ohio, 45219, United States
University of Kansas Medical Center Research Institute, Inc.

Kansas City, Kansas, 66160, United States
University of Kentucky Medical Center

Lexington, Kentucky, 40536-0274, United States
University of Minnesota, CTSI

Minneapolis, Minnesota, 55414, United States
University of Southern California

Los Angeles, California, 90033, United States
University of Utah Movement Disorders Center

Salt Lake City, Utah, 84108, United States
Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States
Veracity Neuroscience, LLC

Memphis, Tennessee, 38157, United States
Virginia Commonwealth University Department of Neurology

Richmond, Virginia, 23298-0059, United States

Conditions

Explore the condition pages connected to this study.

ATYPICAL PARKINSONISM NEURODEGENERATIVE DISEASES PROGRESSIVE SUPRANUCLEAR PALSY PSP