Can immunotherapy replace the knife? trial aims to spare patients from major cancer surgery
NCT ID NCT06410534
First seen Sep 30, 2025 · Last updated Jun 19, 2026 · Updated 42 times
Summary
This study was designed to see if the immunotherapy drugs nivolumab (with or without ipilimumab) could help people with colorectal or gastroesophageal cancer avoid or delay surgery. The trial planned to enroll adults with stage I-III cancers, but it was withdrawn before any participants were treated. No conclusions can be drawn from this study.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for COLORECTAL CANCER are added.
By submitting, you agree to our Terms of use
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
National Institutes of Health Clinical Center
Bethesda, Maryland, 20892, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
nivolumab and ipilimumab
What this could lead to
If successful, this approach could help some patients with colorectal or gastroesophageal cancer avoid major surgery by using immunotherapy drugs instead.
What could go wrong
The trial was withdrawn before enrolling any participants, so no results are available. Immunotherapy can cause serious side effects, and it is unknown whether it would effectively control these cancers long-term.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.