Progesterone pills could boost mental health in transgender women
NCT ID NCT06807580
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether taking oral progesterone (200 mg daily) can reduce psychological distress in transgender women who have been on hormone therapy for at least 6 months. It also looks at effects on sleep, breast size, quality of life, and heart health. About 40 participants will receive either progesterone or a placebo for several weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Progesterone (oral micronized progesterone 200 mg)
- What this could lead to
- If it works, this could point toward a way to improve mental health, sleep, and breast development for transgender women on hormone therapy.
- What could go wrong
- This is a small early-phase trial with only 40 participants, so results may not apply to everyone. Progesterone can cause side effects like drowsiness or liver issues.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Emory Transgender Clinic
RECRUITINGAtlanta, Georgia, 30308, United States