Could a cheap pill replace IV drips for ulcer bleeding?
NCT ID NCT04394663
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study compares high-dose oral omeprazole (a common acid-reducing pill) against standard intravenous pantoprazole (given through a vein) in 128 adults who have had a bleeding stomach ulcer treated with endoscopy. The goal is to see if the oral pill is just as good at preventing rebleeding over 3 days. If it works, it could simplify treatment and lower costs.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- omeprazole (oral) and pantoprazole (intravenous)
- What this could lead to
- If successful, this could show that a cheaper, easier-to-take oral medication is just as effective as an IV drip for preventing ulcer rebleeding after endoscopy.
- What could go wrong
- This is a small, early-phase trial (128 participants) testing a non-inferiority hypothesis, so results may not apply broadly. The oral drug may not control stomach acid as consistently as the IV drip.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
King Chulalongkorn Memorial Hospital
RECRUITINGPathum Wan, Bangkok, 10330, Thailand
-
Surin Hospital
RECRUITINGSurin, 32000, Thailand
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