New pill tested to fight sickle cell pain crises

NCT ID NCT05405114

Completed Disease control Sponsor: Novo Nordisk A/S Source: ClinicalTrials.gov ↗

Summary

This study tested a new oral medicine called NDec to see if it could help adults with sickle cell disease. The goal was to see if taking NDec capsules twice a week for about a year could improve blood health and reduce painful crises. Participants were randomly assigned to receive either NDec, a placebo (inactive pill), or continue their current treatment to compare the results.

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Contacts and locations

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Locations

Acıbadem Adana Hastanesi-Hematoloji

Adana, 01130, Turkey (Türkiye)
Aghia Sophia Childrens' Hospital

Goudi, 11527, Greece
All India Institute of Medical Sciences (AIIMS), Raipur

Raipur, Chhattisgarh, 492099, India
Azienda Ospedale Universita Padova

Padua, 35128, Italy
Azienda Ospedaliera Universitaria Integrata Verona Policlinico GB Rossi - Borgo Roma

Verona, 37134, Italy
BAPS Pramukh Swami Hospital

Surat, Gujarat, 395009, India
Center for Inherited Blood Dis

Orange, California, 92868, United States
Central Middlesex Hospital

London, NW10 7NS, United Kingdom
Centre Hospitalier Universitaire Grenoble Alpes-Site Nord Michallon-3

Grenoble, 38043, France
Charlotte Maxeke Johannesburg Academic Hospital

Parktown, Johannesburg, Gauteng, 2193, South Africa
Christian Medical College Hospital, Vellore

Ranipet, Tamil Nadu, 632517, India
Christian Medical College Hospital, Vellore

Vellore, Tamil Nadu, 632004, India
Clinical and Transl Res Center

Aurora, Colorado, 80045, United States
Cure 4 the Kids Foundation

Las Vegas, Nevada, 89135, United States
East Carolina Univ-Greenville

Greenville, North Carolina, 27834, United States
Fondazione IRCSS Ca' Granda Ospedale Maggiore Policlinico

Milan, 20122, Italy
Foundation for Sickle Cell Disease Research

Hollywood, Florida, 33023, United States
Gen Univ Hospital of Patras, Thalassemia/Hemoglobinopathies

Pátrai, 26504, Greece
General Hospital Of Larissa Koutlibaneio And Triantafylleio - Thalassemia and SCD Unit

Larissa, 41221, Greece
Government Medical College and Hospital

Nagpur, Maharashtra, 440003, India
Government Medical College and Super Speciality Hospital, Nagpur

Nagpur, Maharashtra, 440003, India
Government Medical College and Super Speciality Hospital, Nagpur

Nagpur, Maharashtra, 440009, India
Government Medical College, Kozhikode

Kozhikode, Kerala, 673008, India
Guy's Hosptial

London, SE1 9RT, United Kingdom
Hacettepe Üniversitesi Hastanesi- Hematoloji

Ankara, 06230, Turkey (Türkiye)
Harbor-UCLA Medical Center

Torrance, California, 90502-2004, United States
Hospices Civils de Lyon-Hopital Edouard Herriot

Lyon, 69437, France
Hospital Nini

Tripoli, 1434, Lebanon
Hospital Regional Universitario de Málaga

Málaga, 29010, Spain
Hospital Universitario La Paz

Madrid, 28046, Spain
Howard University

Washington D.C., District of Columbia, 20060, United States
IMS and SUM Hospital

Bhubaneswar, Odisha, 751003, India
J.S.S.Hospital

Mysore, Karnataka, 570004, India
Jacobi Medical Center

The Bronx, New York, 10461, United States
K.J Somaiya Hospital and Research Centre

Mumbai, Maharashtra, 400022, India
KIMS - Kingsway Hospital

Nagpur, 440001, India
Kings College Hospital

London, SE5 9RS, United Kingdom
LHSC - Victoria Hospital

London, Ontario, ON N6A 5W9, Canada
Manchester Royal Infirmary

Manchester, M13 9WL, United Kingdom
McGill University Health Centre

Montreal, Quebec, H4A 3J1, Canada
Medical Univ of SC Charleston

Charleston, South Carolina, 29425, United States
Mersin Üniversitesi Tip Fakültesi Hastanesi- Çiftlikköy Yerleşkesi- Hematoloji

Mersin, 33110, Turkey (Türkiye)
Mississippi Center Advanced Medicine

Madison, Mississippi, 39110, United States
Mount Sinai School of Medicine

New York, New York, 10029, United States
NRS Medical College & Hospital

Kolkata, West Bengal, 700014, India
NRS Medical College & Hospital

Kolkata, West Bengal, 70014, India
Nirmal Hospital Pvt. Ltd.

Surat, Gujarat, 395002, India
Ospedali Galliera

Genova, 16128, Italy
Policlinico GB Rossi

Verona, 37134, Italy
S.C.B. Medical College

Cuttack, Odisha, 753007, India
SSG Hospital, Baroda

Vadodara, Gujarat, 390001, India
SSG Hospital, Baroda

Vadodara, Gujarat, 390006, India
Sanjay Gandhi Postgraduate Institute of Medical Sciences

Lucknow, Uttar Pradesh, 226014, India
St Christopher Hosp for Child

Philadelphia, Pennsylvania, 19134, United States
Sultan Qaboos University Hospital

Muscat, 123, Oman
Toronto General Hospital, Liver Clinic

Toronto, Ontario, M5G 2C4, Canada
Toronto General Hospital, Liver Clinic

Toronto, Ontario, M5G2C4, Canada
Tulane Sickle Cell Ctr- So LA

Metairie, Louisiana, 70002, United States
UCSF Oakland Benioff Children's Hospital

Oakland, California, 94609, United States
Univ Oklahoma HSC_Okla City

Oklahoma City, Oklahoma, 73104, United States
Univ Texas HSC-Houston

Houston, Texas, 77030, United States
University Hospital of Wales

Cardiff, CF14 4XW, United Kingdom
University Of Illinois at Chicago

Chicago, Illinois, 60612, United States
University Of South Alabama

Mobile, Alabama, 36617, United States
University of Miami Hospital & Clinics

Miami, Florida, 33136, United States
University of Oklahoma Health Sciences Center_Oklahoma City

Oklahoma City, Oklahoma, 73104, United States
Victoria Hospital (Bangalore Medical College and Research Institute)

Bangalore, Karnataka, 560002, India
Yashoda hospital

Hyderabad, Telangana, 500082, India
Çukurova Üniversitesi Tıp Fakültesi Balcalı Hastanesi- Hematoloji

Adana, 01130, Turkey (Türkiye)

Conditions

Explore the condition pages connected to this study.

SICKLE CELL DISEASE