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Mouth bacteria linked to high blood pressure in kids

NCT ID NCT07236125

Knowledge-focused Sponsor: Yelda Kasımoğlu Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now This study
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Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
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Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

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Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
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Status unknown
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First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how bacteria in the mouth might help control blood pressure in children aged 10-18 with high blood pressure. Researchers will collect saliva and do simple mouth exams to compare these children with healthy peers. No drugs or treatments are given—the goal is to learn more about the link between oral bacteria and hypertension. Findings could lead to new ways to detect or prevent high blood pressure early.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 48 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2026

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants will be recruited from children and adolescents aged 10-18 years presenting to the Istanbul University Faculty of Dentistry, Department of Pediatric Dentistry, as well as pediatric patients followed by the Pediatric Nephrology Clinic who have been diagnosed with primary hypertension. The study population includes two groups: (1) adolescents with confirmed primary hypertension, not on antihypertensive medication, and (2) age- and sex-matched healthy controls without systemic disease or blood pressure abnormalities. All participants will be systemically healthy, cooperative, and able to provide saliva samples, undergo oral examinations, and complete questionnaire assessments. Recruitment will be consecutive based on clinic attendance, and all participants and their families will be informed about study procedures before enrollment.

Ages

10 to 18 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Applied to the Istanbul University Faculty of Medicine, Department of Pediatric Nephrology, * Between the ages of 10 and 18, * Diagnosed with primary hypertension, * Clinically excluded from secondary hypertension or heart failure, * No systemic or chronic disease other than hypertension, * No periodontal disease, dental infection, or oral mucosal disease, * Not taking regular antihypertensive or other medications for a chronic disease, * Not having received antibiotic treatment in the last 3 months, * Patients who have not used mouthwash in the last 3 months, * Have no allergies to nitrate-rich foods, * Both male and female patients will be included. Exclusion Criteria: * Younger than 10 years of age or older than 18 years of age * Clinically diagnosed with secondary hypertension or heart failure * Have a systemic disease * Have periodontal disease, dental infection, or oral mucosal disease * Are taking regular antihypertensive medications or other chronic illnesses * Have received antibiotic treatment within the last 3 months * Have used mouthwash within the last 3 months * Are allergic to nitrate-rich foods will not be included in the study.

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Conditions

The condition(s) this trial relates to.

essential hypertension

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Primary hypertension

How to take part

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  1. The places running it

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  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Istanbul University Faculty of Dentistry

    RECRUITING

    Istanbul, Fatih, 34093, Turkey (Türkiye)

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