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Non-Opioid pain pump put to the test after colon surgery

NCT ID NCT07821307

Symptom relief Sponsor: Samsung Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 15, 2026 · Last updated Sep 16, 2026 · Updated 1 time

Summary

Researchers are testing an experimental drug called opiranserin (VVZ-149) to see if it eases pain after laparoscopic colon surgery. The trial enrolls 66 adults scheduled for this operation. Participants receive the drug through a patient-controlled pump or a placebo, and researchers track pain levels and how much pain medication each person uses over 12 hours.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
opiranserin (VVZ-149), an experimental non-opioid pain drug given through a patient-controlled pump
What this could lead to
If it works, opiranserin could offer a non-opioid option for controlling pain after surgery, giving patients an alternative to drugs like morphine.
What could go wrong
This is a small phase 2 trial of 66 people, so any pain relief seen may not hold up in larger studies. Opiranserin may not beat standard pain control, and it could cause side effects that outweigh its benefits.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

66 people

The number who actually took part.

Started

Jul 2025

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

19 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Subjects must have the ability to voluntarily provide written informed consent, understand study * Men and women subjects aged ≥19 years and \<75 years * Female subjects who are not pregnant or breastfeeding * Subjects must be undergoing a planned first laparoscopic colectomy * Subjects classified in American Society Anesthesiologist (ASA) risk class of I or II Exclusion Criteria: * Subjects undergoing emergency or unplanned surgery * Subjects who had a previous laparoscopic colectomy or resection procedure * Subjects with pre-existing conditions causing preoperative pain around the site of surgery * Female subjects who are pregnant or breastfeeding * Diagnosis of chronic pain (e.g., persistent pain with the intensity of NRS ≥ 5 at baseline)

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pain, postoperative / acute pain

Contacts and locations

Locations

  • Samsung Medical Center

    Seoul, South Korea