Can a nasal spray reveal the Brain's role in feeling rejected?
NCT ID NCT04650841
First seen Jan 09, 2026 · Last updated Apr 25, 2026 · Updated 15 times
Summary
This early-phase study looks at how the brain's opioid system—its natural painkiller—affects placebo effects for both physical pain and the pain of social rejection. Sixty adults who recently went through an unwanted breakup will receive either naloxone (which blocks opioids) or a saline spray, and then undergo brain scans while experiencing pain and rejection-related stimuli. The goal is to understand the brain mechanisms behind these placebo effects, not to provide treatment.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Dartmouth College
Hanover, New Hampshire, 03755, United States
Contact Email: •••••@•••••
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