Could a simple abdomen wash cut opioid use after cancer surgery?
NCT ID NCT07706348
First seen Jul 15, 2026 · Last updated Jul 16, 2026 · Updated 1 time
Summary
This trial investigates whether rinsing the inside of the abdomen with a combination of ondansetron and lidocaine during surgery can reduce pain and the need for morphine afterward. The study includes 20 adults undergoing major lower abdominal cancer surgery. Researchers will measure total morphine use in the first 24 hours and how long patients go before requesting additional pain relief.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- a combination of ondansetron and lidocaine given as an intraperitoneal wash during surgery
- What this could lead to
- If effective, this approach could offer a simple, low-cost way to reduce postoperative pain and the need for strong opioid painkillers after abdominal cancer surgery.
- What could go wrong
- This is a very small early-phase trial with only 20 participants, so results may not be generalizable. The drugs are used off-label in this way, and there is a risk of side effects or no added benefit over standard care.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Assiut University - South Egypt Cancer Instiute
RECRUITINGAsyut, Egypt