New cancer antibody ONC-841 enters human trials

NCT ID NCT06352359

Recruiting now Disease control Sponsor: OncoC4, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage trial tests a new drug called ONC-841 in people with advanced solid tumors that have spread. The drug is an antibody designed to help the immune system attack cancer cells. The study will first find a safe dose, then test it alone and with standard treatments for brain and colorectal cancers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ONC-841 (an antibody that targets SIGLEC10 to help the immune system fight cancer)
What this could lead to: If successful, this could point toward a new treatment option for advanced solid tumors like glioblastoma and colorectal cancer.
What could go wrong: This is an early Phase 1/2 trial with only 72 participants, so it is too soon to know if ONC-841 is safe or effective. Side effects and lack of benefit are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID TUMOR

Contacts and locations

Locations

AdventHealth Medical Group Oncology Research at Celebration
RECRUITING

Kissimmee, Florida, 34747, United States
Huntsman Cancer Institute, University of Utah
RECRUITING

Salt Lake City, Utah, 84112, United States
MD Anderson Cancer Center
RECRUITING

Houston, Texas, 770360, United States
Norton Cancer Center
RECRUITING

Louisville, Kentucky, 40202, United States
Rogel Cancer Center, University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States
Thomas Jefferson University Hospital
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
UF Health Cancer Center, University of Florida
RECRUITING

Gainesville, Florida, 32610, United States
University of California at Davis Cancer Center
RECRUITING

Sacramento, California, 95817, United States

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