Experimental drug aims to strengthen bones in brittle bone disease
NCT ID NCT05231668
First seen Nov 01, 2025 · Last updated May 13, 2026 · Updated 28 times
Summary
This early-stage study tested a single dose of an experimental drug called SAR439459 in 16 adults with osteogenesis imperfecta (brittle bone disease). The main goal was to check safety and how the drug moves through the body, with a secondary look at bone density changes over 24 weeks. The study was terminated early, so results are limited.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Baylor College of Medicine - Site Number:8400003
Houston, Texas, 77030, United States
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Bone Research and Education Centre_Site Number :1240003
Oakville, Ontario, L6M 1M1, Canada
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Cincinnati Children's Hospital Medical Center Site Number : 8400010
Cincinnati, Ohio, 45229, United States
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Department of Medicine/ School of Clinical Sciences at Monash Health Monash University_246 Clayton Road_Site Number :0360002
Clayton, Victoria, 3168, Australia
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Hopital Edouard Herriot _Site Number :2500002
Lyon, 69003, France
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Hopital Lariboisiere_Site Number :2500001
Paris, 75010, France
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Indiana University School of Medicine_Site Number: 8400002
Indianapolis, Indiana, 46202, United States
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Kennedy Krieger Institute_Site number 8400004
Baltimore, Maryland, 21205, United States
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Toronto general Hospital_Site Number :1240002
Toronto, M5G 2C4, Canada
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UCLA Health_Site Number: 8400006
Los Angeles, California, 90095, United States
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Vanderbilt University Site Number : 8400011
Nashville, Tennessee, 37232, United States
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Westmead Hospital_Site Number :0360003
Westmead, New South Wales, 2145, Australia
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Yale University - Site Number:8400007
New Haven, Connecticut, 06510, United States
Conditions
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