New MS drug shows promise in Head-to-Head trial against standard therapies

NCT ID NCT04788615

First seen Nov 01, 2025 · Last updated May 13, 2026 · Updated 29 times

Summary

This study tested a monthly injection of ofatumumab against other standard first-line medications for people newly diagnosed with relapsing multiple sclerosis (MS). The goal was to see which treatment better controls disease activity without relapses, new brain lesions, or worsening disability. 185 adults aged 18-55 took part, and the results help doctors choose the best initial therapy for MS.

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Contacts and locations

Locations

  • Novartis Investigative Site

    Bayonne, Bayonne Cedex, 64109, France

  • Novartis Investigative Site

    Amiens, 80054, France

  • Novartis Investigative Site

    Bordeaux, 33076, France

  • Novartis Investigative Site

    Clermont-Ferrand, 63003, France

  • Novartis Investigative Site

    Créteil, 94010, France

  • Novartis Investigative Site

    Gonesse, 95500, France

  • Novartis Investigative Site

    Grenoble, 38043, France

  • Novartis Investigative Site

    Montpellier, 34090, France

  • Novartis Investigative Site

    Nice, 06202, France

  • Novartis Investigative Site

    Nîmes, 30029, France

  • Novartis Investigative Site

    Poissy, 78303, France

  • Novartis Investigative Site

    Rennes, 35033, France

  • Novartis Investigative Site

    Strasbourg, 67000, France

  • Novartis Investigative Site

    Frankfurt am Main, Hesse, 60590, Germany

  • Novartis Investigative Site

    Westerstede, Lower Saxony, 26655, Germany

  • Novartis Investigative Site

    Cologne, North Rhine-Westphalia, 50937, Germany

  • Novartis Investigative Site

    Bayreuth, 95445, Germany

  • Novartis Investigative Site

    Berlin, 12101, Germany

  • Novartis Investigative Site

    Berlin, 13353, Germany

  • Novartis Investigative Site

    Bielefeld, 33647, Germany

  • Novartis Investigative Site

    Dortmund, 44137, Germany

  • Novartis Investigative Site

    Heidelberg, 69120, Germany

  • Novartis Investigative Site

    Siegen, 57076, Germany

  • Novartis Investigative Site

    Ulm, 89073, Germany

  • Novartis Investigative Site

    Montichiari, BS, 25018, Italy

  • Novartis Investigative Site

    Milan, MI, 20132, Italy

  • Novartis Investigative Site

    Roma, RM, 00133, Italy

  • Novartis Investigative Site

    Roma, RM, 00189, Italy

  • Novartis Investigative Site

    Orbassano, TO, 10043, Italy

  • Novartis Investigative Site

    Naples, 80131, Italy

  • Novartis Investigative Site

    Santiago Compostela, A Coruna, 15706, Spain

  • Novartis Investigative Site

    Salt, Girona, 17190, Spain

  • Novartis Investigative Site

    El Palmar, Murcia, 30120, Spain

  • Novartis Investigative Site

    Barakaldo, Vizcaya, 48903, Spain

  • Novartis Investigative Site

    Barcelona, 08035, Spain

  • Novartis Investigative Site

    Madrid, 28009, Spain

  • Novartis Investigative Site

    Madrid, 28034, Spain

  • Novartis Investigative Site

    Madrid, 28040, Spain

  • Novartis Investigative Site

    Málaga, 29010, Spain

  • Novartis Investigative Site

    Seville, 41009, Spain

  • Novartis Investigative Site

    Valencia, 46026, Spain

Conditions

Explore the condition pages connected to this study.