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Can a blood test predict who recovers well from heart surgery?

NCT ID NCT07793708

Knowledge-focused Sponsor: University of Chile Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 28, 2026 · Last updated Aug 28, 2026

Summary

This study follows 75 older adults having elective heart surgery to understand why some recover quickly while others face complications like delirium or slow recovery. Researchers will measure frailty, physical and mental function, and a blood marker of biological stress called GDF-15 before and after surgery. The goal is to build a clearer picture of resilience in aging, which could help doctors identify who needs extra support.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Observational study with blood biomarker measurement (GDF-15) and clinical assessments; no intervention is administered.
What this could lead to
If successful, this could lead to better ways to predict which older adults will recover well after cardiac surgery, and guide personalized care to improve recovery.
What could go wrong
This is a small pilot study, so findings may not apply to all older adults. It only observes, so it cannot prove that any intervention improves resilience.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 75 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Oct 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population will consist of adults aged 65 years or older undergoing elective cardiac surgery, recruited between 2025 and 2026 at Clínica Bicentenario, a high-complexity surgical center located in Santiago, Chile.

Ages

65 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Older adults (≥ 65 años) undergoing elective cardiac surgery via median sternotomy, including coronary artery bypass grafting (CABG) and/or valvular surgery. * Independence in basic daily activities, defined as a Barthel Index score ≥80. Exclusion Criteria: * Emergency surgery for any indication * Terminal illness, defined as a life expectancy of less than 12 months * History of cognitive impairment, defined as a documented diagnosis of dementia and/or current treatment with memantine or donepezil * Advanced hepatic or renal failure, defined as Child-Pugh class C liver disease or chronic dialysis

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Conditions

The condition(s) this trial relates to.

coronary artery disorder Frailty heart valve disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiac surgery recovery Frailty Resilience

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Clinica Bicentenario Red Salud

    Santiago, Chile

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