New hope for lymphoma: experimental drug combo takes on standard care in major trial

NCT ID NCT06091865

Recruiting now Disease control Sponsor: Regeneron Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Feb 05, 2026 · Last updated May 23, 2026 · Updated 14 times

Summary

This study compares an experimental drug (odronextamab) plus chemotherapy against the current standard treatment (rituximab plus chemotherapy) for people with untreated diffuse large B-cell lymphoma. About 904 participants will be enrolled to see if the new combination works better and is safe. The goal is to improve disease control and survival.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

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Locations

A.O.U. di Modena
RECRUITING

Modena, 41124, Italy
AOU Maggiore della Carita
RECRUITING

Novara, 28100, Italy
ASST Monza Ospedale San Gerardo
RECRUITING

Monza, Monza E Brianza, 20900, Italy
AZ St.-Elisabeth Herentals vzw
RECRUITING

Herentals, Antwerp, 2200, Belgium
Aidport
RECRUITING

Skorzewo, Wielkopolska, 60185, Poland
Asan Medical Center
RECRUITING

Seoul, 05505, South Korea
Assistance Publique-Hopitaux de Paris (AP-HP)
RECRUITING

Paris, 75571, France
Avicenne Hospital
RECRUITING

Bobigny, Île-de-France Region, 93000, France
Az Delta
RECRUITING

Roeselare, West-Vlaanderen, 8800, Belgium
Azienda Ospedaliera di Perugia
RECRUITING

Perugia, 06132, Italy
Beaumont Hospital
WITHDRAWN

Dublin, Leinster, D09V2N0, Ireland
Beth Israel Deaconess Medical Center
RECRUITING

Boston, Massachusetts, 02215, United States
Bnai Zion Medical Center
RECRUITING

Haifa, 31048, Israel
CHRU de Tours
RECRUITING

Tours, Centre-Val de Loire, 37044, France
CHU Nimes Institut de Cancerologie
RECRUITING

Nîmes, 30029, France
CHU de Saint-Etienne
RECRUITING

Saint-Etienne, 42055, France
Calvary Mater Newcastle
RECRUITING

Waratah, New South Wales, 2298, Australia
Cancer and Hematology Centers of Western Michigan
RECRUITING

Grand Rapids, Michigan, 49503, United States
Center for Oncology and Blood Disorders
WITHDRAWN

Houston, Texas, 77030, United States
Centre Hospitalier Metropole Savoie
RECRUITING

Chambéry, Savoie, 73000, France
Centre Hospitalier Regional de Verviers
RECRUITING

Verviers, Liege, 4800, Belgium
Centre Hospitalier Universitaire (CHU) Rennes
RECRUITING

Rennes, Brittany Region, 35033, France
Centre Hospitalier Universitaire (CHU) de Bordeaux
RECRUITING

Pessac, New Aquitaine, 33600, France
Centre Hospitalier Universitaire Angers
RECRUITING

Angers, 49000, France
Centre Hospitalier Universitaire De Poitiers
RECRUITING

Poitiers, New Aquitaine, 86000, France
Centro Oncologia de Precision Universidad Mayor
RECRUITING

Santiago, Santiago Metropolitan, 7560907, Chile
Centrum Innowacyjnych Terapii Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie
RECRUITING

Lublin, 20-954, Poland
Chaing Mai University
RECRUITING

Chiang Mai, 50200, Thailand
Chang Gung Medical Foundation Chia Yi Branch
RECRUITING

Buzi, Chiayi County, 613, Taiwan
Chang Gung Memorial Hospital - Linkou Branch
RECRUITING

Taoyuan, Hunan Province, 33305, Taiwan
Change Annecy
RECRUITING

Metz-Tessy, 74374, France
Changhua Christian Hospital
RECRUITING

Changhua, 50006, Taiwan
Chulalongkorn University
RECRUITING

Bangkok, Krung Thep Maha Nakhon [Bangko], 10330, Thailand
Clinic Frankfurt (Oder)
RECRUITING

Frankfurt am Main, Hesse, 15236, Germany
Clinica Alemana de Santiago
RECRUITING

Santiago, 7650568, Chile
Clinical Research Alliance Inc
WITHDRAWN

Westbury, New York, 11590, United States
Community Cancer Trials of Utah
RECRUITING

Ogden, Utah, 84405, United States
David Geffen School of Medicine at UCLA
RECRUITING

Los Angeles, California, 90095, United States
Dokuz Eylul University
RECRUITING

Izmir, 35340, Turkey (Türkiye)
Dong-A University Hospital
RECRUITING

Busan, 49201, South Korea
Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital
RECRUITING

Yenimahalle, Ankara, 06200, Turkey (Türkiye)
Duke University Medical Center
RECRUITING

Durham, North Carolina, 27710, United States
East Carolina University
RECRUITING

Greenville, North Carolina, 27834, United States
Ege University
RECRUITING

Izmir, 35100, Turkey (Türkiye)
Epworth Freemasons
RECRUITING

East Melbourne, Victoria, 3121, Australia
Faculty of Medicine
RECRUITING

Khon Kaen, 40002, Thailand
Federico II University
RECRUITING

Naples, 80131, Italy
Fondazione IRCCS Policlinico San Matteo
RECRUITING

Pavia, 27100, Italy
Fundacion Jimenez Diaz University Hospital
RECRUITING

Madrid, 28040, Spain
Gachon University Gil Medical Center
RECRUITING

Incheon, Namdong-Gu, 21565, South Korea
Galilee Medical Center
RECRUITING

Nahariya, 2210001, Israel
Gazi Universitesi
RECRUITING

Beşevler, 6500, Turkey (Türkiye)
Gustave Roussy
RECRUITING

Villejuif, Île-de-France Region, 94800, France
Hadassah Medical Center
RECRUITING

Jerusalem, 91200, Israel
Hanusch Krankenhaus
RECRUITING

Vienna, 1140, Austria
Hematological Praxis Dresden
RECRUITING

Dresden, Saxony, 01307, Germany
Hematology - Città della Salute e della Scienza di Torino
RECRUITING

Turin, 10126, Italy
Henry Ford Health System
RECRUITING

Detroit, Michigan, 48202, United States
Hopital Saint Vincent-de-Paul
RECRUITING

Lille, Nord, 5900, France
Hopital Victor Dupouy Argenteuil
RECRUITING

Argenteuil, Île-de-France Region, 95100, France
Hospital Ampang
RECRUITING

Ampang, Selangor, 68000, Malaysia
Hospital Clinico Universidad de Los Andes
RECRUITING

Santiago, Las Condes, 7620157, Chile
Hospital Clinico Universitario Santiago de Compostela
RECRUITING

Santiago de Compostela, A Coruna, 15706, Spain
Hospital General Universitario de Toledo
WITHDRAWN

Toledo, 45007, Spain
Hospital Queen Elizabeth
RECRUITING

Kota Kinabalu, Sabah, 88200, Malaysia
Hospital Sant Pau
RECRUITING

Barcelona, 08041, Spain
Hospital Tg Ampuan Afzan
RECRUITING

Kuantan, Pahang, 25200, Malaysia
Hospital Universitari Mutua Terrassa
RECRUITING

Terrassa, Barcelona, 08221, Spain
Hospital Universitari Parc Tauli
RECRUITING

Sabadell, Barcelona, 08208, Spain
Hospital Universitario Central de Asturias
RECRUITING

Oviedo, Principality of Asturias, 33011, Spain
Hospital Universitario HM Sanchinarro
RECRUITING

Madrid, 28050, Spain
Hospital Universitario Infanta Leonor
RECRUITING

Madrid, 28031, Spain
Hospital Universitario Marques de Valdecilla
RECRUITING

Santander, Cantabria, 39008, Spain
Hospital Universitario Quironsalud Madrid
RECRUITING

Pozuelo de Alarcón, Madrid, 28223, Spain
Hospital Universitario Ramon y Cajal
RECRUITING

Madrid, 28034, Spain
Hospital Universitario Virgen Macarena
RECRUITING

Seville, 41009, Spain
Hospital Universitario Virgen del Rocio
RECRUITING

Seville, Andalusia, 41013, Spain
Hospital Universitario de Navarra
RECRUITING

Pamplona, Navarre, 31008, Spain
Hospital Virgen De Las Nieves De Granada
RECRUITING

Granada, 18014, Spain
Icon Cancer Centre - Wesley
RECRUITING

Auchenflower, Queensland, 4066, Australia
Indiana University Melvin and Bren Simon Comprehensive Cancer Center
RECRUITING

Indianapolis, Indiana, 46202, United States
Inje University Busan Paik Hospital
RECRUITING

Busan, 47392, South Korea
Inmunocel
RECRUITING

Santiago, Santiago Metropolitan, 7580206, Chile
Institut Jules Bordet
RECRUITING

Brussels, 1000, Belgium
Instituto Valenciano de Oncologia
RECRUITING

Valencia, 46009, Spain
Investigative Clinical Research of Indiana
RECRUITING

Noblesville, Indiana, 46062, United States
Istanbul University Istanbul Faculty of Medicine
RECRUITING

Istanbul, 34418, Turkey (Türkiye)
Istituto Europeo di Oncologia
RECRUITING

Milan, 20141, Italy
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
RECRUITING

Meldola, Forli-Cesena, 47014, Italy
Keimyung University Dongsan Hospital
RECRUITING

Daegu, 42601, South Korea
Kepler University Hospital
RECRUITING

Linz, Upper Austria, 4020, Austria
Kliniken Ostalb Stauferklinikum Schwab Gmund
RECRUITING

Mutlangen, Gmund, D-73557, Germany
Klinikum Wels-Grieskirchen
RECRUITING

Wels, 4600, Austria
Landeskrankenhaus Hochsteiermark
RECRUITING

Leoben, Styria, 8700, Austria
Liverpool Hospital
RECRUITING

Liverpool, New South Wales, 2170, Australia
Matopolskie Centrum Medyczne S.C.
RECRUITING

Krakow, Lesser Poland Voivodeship, 30-510, Poland
Medical University Graz
RECRUITING

Graz, 8036, Austria
Medical University of Vienna
RECRUITING

Vienna, 1090, Austria
NHS Grampian: Aberdeen Royal Infirmary
RECRUITING

Aberdeen, AB25 2ZN, United Kingdom
Nantes University Hospital
RECRUITING

Nantes, Pays de la Loire Region, 44093, France
National Cancer Centre of Singapore
RECRUITING

Singapore, 168583, Singapore
National Taiwan University Hospital
RECRUITING

Taipei, 10002, Taiwan
National University Hospital Singapore
RECRUITING

Singapore, 119074, Singapore
Ondokuz Mayis Universitesi Tip Fakultesi Hastanesi
RECRUITING

Samsun, 55239, Turkey (Türkiye)
Ospedale Santa Maria delle Croci
RECRUITING

Ravenna, 48121, Italy
Pindara Private Hospital
RECRUITING

Benowa, Queensland, 4217, Australia
Polyclinique Bordeaux Nord Aquitaine
RECRUITING

Bordeaux, Gironde, 33077, France
Pratia Poznan Medical Center
WITHDRAWN

Poznan, Wielkopolska, 60185, Poland
Prohealth Care Inc
WITHDRAWN

Waukesha, Wisconsin, 53188, United States
Pusan National University Hospital
RECRUITING

Busan, 49241, South Korea
Robert-Bosch-Krankenhaus
RECRUITING

Stuttgart, Baden-Wurttemberg, 70376, Germany
Rutgers Cancer Institute of New Jersey
RECRUITING

New Brunswick, New Jersey, 08901, United States
Sakarya University Medical Faculty
RECRUITING

Sakarya, 54290, Turkey (Türkiye)
Samson Assuta Ashdod University Hospital
RECRUITING

Ashdod, 7747629, Israel
Samsung Medical Center
RECRUITING

Seoul, 06351, South Korea
Santa Maria della Misericordia
RECRUITING

Udine, 33100, Italy
Seoul St Marys Hospital
RECRUITING

Seoul, 137-701, South Korea
Son Espases University Hospital
RECRUITING

Palma, Balearic Islands, 07120, Spain
Sriraj Hospital
RECRUITING

Bangkok, 10700, Thailand
St James Hospital and Trinity College Dublin
RECRUITING

Dublin, D08, Ireland
St Vincent Ascension at Peyton Manning Childrens Hospital
RECRUITING

Indianapolis, Indiana, 46260, United States
St. Vincent Hospital - The Catholic University of Korea
RECRUITING

Suwon, Gyeonggi-do, 16247, South Korea
Stadtisches Krankenhaus Kiel
RECRUITING

Kiel, 24116, Germany
Stony Brook University Hospital
RECRUITING

Stony Brook, New York, 11794, United States
Subang Jaya Medical Center
RECRUITING

Subang Jaya, Selangor, 47500, Malaysia
Szpital Szpecjalistyczny w Walbrzychu
RECRUITING

Wałbrzych, 58-300, Poland
Szpital Uniwersytecki Nr2 Bydgoszcz
WITHDRAWN

Bydgoszcz, 85-168, Poland
Taipei Medical University - Shuang Ho Hospital
RECRUITING

New Taipei City, 23561, Taiwan
Tan Tock Seng Hospital
RECRUITING

Singapore, 308433, Singapore
Tekirdag Namik Kemal University Hospital
RECRUITING

Tekirdağ, Suleymanpasa, 59100, Turkey (Türkiye)
The Chaim Sheba Medical Center
RECRUITING

Tel Litwinsky, Tel Aviv, 5265601, Israel
The Hillingdon Hospitals NHS Foundation Trust
RECRUITING

Uxbridge, UB8 3NN, United Kingdom
The Tel Aviv Sourasky Medical Center
RECRUITING

Tel Aviv, 64239, Israel
Universitaetsmedizin der Johannes Gutenberg Universitaet Mainz KoeR
RECRUITING

Mainz, Rhineland-Palatinate, 55131, Germany
Universitair Ziekenhuis (UZ) Gent/ Ghent University Hospital
RECRUITING

Ghent, Oost-Vlaanderen, 9000, Belgium
Universitat de Valencia - Hospital Universitari i Politecnic La Fe de Valencia (Hospital La Fe Bulevar Sur)
RECRUITING

Valencia, 46026, Spain
University Hospital Carl Gustav Carus
RECRUITING

Dresden, 01307, Germany
University Hospital Doctor Peset
RECRUITING

Valencia, 46017, Spain
University Hospital Essen
RECRUITING

Essen, North Rhine-Westphalia, 45122, Germany
University Hospital Hradec Kralove
RECRUITING

Hradec Králové, East Bohemia, 50005, Czechia
University Hospital Kralovske Vinohrady
RECRUITING

Prague, 10034, Czechia
University Hospitals Cleveland Medical Center
RECRUITING

Cleveland, Ohio, 44106, United States
University Malaya Medical Centre
RECRUITING

Kuala Lumpur, Kuala Lumpur, 59100, Malaysia
University of California (UC) Davis
RECRUITING

Sacramento, California, 95817, United States
University of California Irvine Medical Center
RECRUITING

Orange, California, 92868, United States
University of Kentucky
RECRUITING

Lexington, Kentucky, 40536, United States
University of Maryland Greenebaum Comprehensive Cancer Center
RECRUITING

Baltimore, Maryland, 21201, United States
Uniwersytecki Szpital Kliniczny
RECRUITING

Wroclaw, Lower Silesian Voivodeship, 50-367, Poland
Uniwersyteckie Centrum Kliniczne, Building of the Non-Invasive Medicine Center
RECRUITING

Gdansk, 80-952, Poland
VM Medical Park Mersin Hospital
RECRUITING

Mezitli, Mersin, 33200, Turkey (Türkiye)
Vseobecna Fakultni Nemocnice V Praze
RECRUITING

Prague, 12808, Czechia
Wanfang Hospital
RECRUITING

Taipei, 00116, Taiwan
Wielospecjalistyczne Centrum Onkologii i Traumatologii
RECRUITING

Lodz, Łódź Voivodeship, 93-510, Poland
Yeouido St. Marys Hospital
RECRUITING

Seoul, 07345, South Korea
Yeyungnam University Medical Center
RECRUITING

Daegu, 42415, South Korea

Conditions

Explore the condition pages connected to this study.

DIFFUSE LARGE B-CELL LYMPHOMA (DLBCL)