MS drug during pregnancy: what happens to Baby's immune cells?

NCT ID NCT04998812

First seen Nov 01, 2025 · Last updated Jun 10, 2026 · Updated 32 times

Summary

This study checked if the multiple sclerosis drug ocrelizumab passes from mother to baby during pregnancy and how it affects the baby's B cells (a type of immune cell). Researchers followed 70 pregnant women with MS or clinically isolated syndrome who had taken ocrelizumab up to 6 months before pregnancy or during the first trimester. The goal was to measure B cell levels in the infants after birth to understand any potential effects.

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Contacts and locations

Locations

  • Hopital Pierre Wertheimer - Hopital Neurologique

    Bron, 69003, France

  • Hosp. Clinico San Carlos

    Madrid, 28040, Spain

  • Hospital of the University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

  • Hôpital de la Pitié Salpétrière

    Paris, 75013, France

  • Inselspital Bern

    Bern, 3010, Switzerland

  • MultipEL Studies - Institut für klinische Studien

    Hamburg, 22179, Germany

  • St. Josef Hospital GmbH

    Bochum, 44791, Germany

  • The Ken and Ruth Davee department of Neurology

    Chicago, Illinois, 60611-4296, United States

  • University Of Colorado

    Aurora, Colorado, 80045, United States

  • University of California San Francisco

    San Francisco, California, 94158, United States

  • Universitätsspital Basel

    Basel, 4031, Switzerland

Conditions

Explore the condition pages connected to this study.