Hope for rare kidney disease: drug trial targets protein leak
NCT ID NCT06295770
First seen Jun 25, 2026 · Last updated Jun 25, 2026
Summary
This study tests whether obinutuzumab, a drug used for certain blood cancers, can help people with fibrillary glomerulonephritis (FGN), a rare kidney condition that causes protein leakage and can lead to kidney failure. Twenty adults with confirmed FGN will receive the drug intravenously twice in the first month and again at six months. Researchers will measure changes in protein levels in urine over a year to see if the drug improves kidney health.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Mayo Clinic
RECRUITINGRochester, Minnesota, 55905, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
obinutuzumab (Gazyva)
What this could lead to
If it works, this could point toward a treatment for fibrillary glomerulonephritis, a rare kidney disease, by reducing protein leakage and preserving kidney function.
What could go wrong
This is a small, early-phase trial with only 20 people, so results may not apply broadly. The drug may cause side effects like infections or infusion reactions, and it's not yet proven to be effective.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.