Can a B-Cell blocker tame lupus?

NCT ID NCT06559163

Ongoing Disease control Sponsor: Zenas BioPharma (USA), LLC Source: ClinicalTrials.gov ↗

First seen Aug 18, 2026 · Last updated Aug 19, 2026 · Updated 1 time

Summary

This phase 2 trial is testing whether an experimental drug called obexelimab can safely reduce disease activity in people with systemic lupus erythematosus (SLE). The study enrolls about 190 adults aged 18 to 70 with active lupus. Participants are randomly assigned to receive either obexelimab or a placebo, and researchers will measure how many achieve a meaningful reduction in lupus symptoms using a standard response index.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: obexelimab, an experimental monoclonal antibody that targets B cells to reduce their activity
What this could lead to: If successful, obexelimab could offer a new treatment option for people with systemic lupus erythematosus, potentially reducing disease flares and improving quality of life.
What could go wrong: This is an early-stage trial, so the drug may not prove more effective than placebo. Possible risks include side effects from suppressing the immune system, and results may not apply to all lupus patients.

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Conditions

The condition(s) this trial relates to.

systemic lupus erythematosus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SYSTEMIC LUPUS ERYTHEMATOSUS

Contacts and locations

Locations

AARA Clinical Research - Chicago Arthritis & Regenerative Medicine

Chicago, Illinois, 60661, United States
AARA Clinical Research - Rheumatology Specialty Center

Willow Grove, Pennsylvania, 19090, United States
Accurate Clinical Research

Lake Charles, Louisiana, 70605, United States
Accurate Clinical Research

Houston, Texas, 77089, United States
Anhui Provincial Hospital (The First Affiliated Hospital of USTC)

Hefei, Anhui, 230001, China
Attikon University General Hospital

Chaïdári, Athens, 12462, Greece
Axon Clinical Research

Baltimore, Maryland, 21237, United States
Azienda Ospedaliero Universitaria Pisana

Pisa, 56124, Italy
Azienda Ospedaliero Universitaria di Ferrara

Ferrara, 44124, Italy
Beijing Friendship Hospital, Capital Medical University

Beijing, Beijing Municipality, 100044, China
Buddhist Tzu Chi General Hospital

Chiayi City, 622, Taiwan
CHU de Liege

Liège, 4000, Belgium
California Research Institute

Huntington Park, California, 90255, United States
Centro Reumatologico de Caguas

Caguas, 00725, Puerto Rico
Centro Ricerche Cliniche Di Verona S.r.l.

Verona, 37134, Italy
Centro de Estudios de Investigacion Basica Y Clinica SC

Guadalajara, 44690, Mexico
Centro de Investigacion y Tratamiento Reumatologico S.C.

Mexico City, 11850, Mexico
Centrul Medical de Diagnostic si Tratament Ambulator NEOMED SRL

Brasov, 500283, Romania
Centrum Medyczne Plejady

Krakow, Lesser Poland Voivodeship, 30-363, Poland
Chang Gung Memorial Hospital

Taoyuan, 333, Taiwan
Chung Shan Medical University Hospital

Taichung, 402, Taiwan
Clinical Research of West Florida, Inc

Clearwater, Florida, 33765, United States
Clinical Research of West Florida, Inc.

Tampa, Florida, 33606, United States
Clinstile, S.A. de C.V.

Mexico City, Cuidad de Mexico, 06700, Mexico
Cross Creek Medical Clinic

Fayetteville, North Carolina, 28304, United States
DJL Clinical Research PLLC

Charlotte, North Carolina, 28211, United States
Diagnostic Consultative Center Convex EOOD

Sofia, 1404, Bulgaria
Dr A Naidoo

Umhlanga, 4319, South Africa
Dr I Cantacuzino Clinical Hospital

Bucharest, 030167, Romania
Eme Red Hospitalaria

Mérida, Yucatán, 97000, Mexico
Emory University

Atlanta, Georgia, 30322, United States
FARMOVS

Bloemfontein, 9301, South Africa
FuturMeds Madrid - Santa Elena

Madrid, 28003, Spain
FutureMeds DKF

Madrid, 28002, Spain
General Hospital Asklepieio Voulas

Voula, Athens, 16673, Greece
General Hospital of Thessaloniki ''Hippokration''

Thessaloniki, 54642, Greece
Henry Ford Hospital

Detroit, Michigan, 48202, United States
Hokkaido University Hospital

Kita-ku, Sapporo Hokkaido, 060-8648, Japan
Hospital Egas Moniz

Lisbon, 1349019, Portugal
Hospital Universitario La Paz

Madrid, 28046, Spain
Hospital Universitario Ramón y Cajal

Madrid, 28034, Spain
Hospital Universitario Virgen del Rocío

Seville, 41013, Spain
Hospital Vall d'Hebron

Barcelona, 08035, Spain
Hospital for Special Surgery

New York, New York, 10021, United States
Hospital of Japan Community Health Care Organization Chukyo Hospital

Nagoya, Aichi-ken, 457-8510, Japan
Hospital of Shinkenko Clinic

Naha, Okinawa, 900-001, Japan
Hospital of the University of Occupational and Environmental Health

Kitakyushu-shi, Fukuoka, 807-8556, Japan
IRCCS Ospedale San Raffaele

Milan, 20132, Italy
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubrian

Mexico City, 14080, Mexico
Juno DO, PC

Lansing, Michigan, 48911, United States
Juntendo University Hospital

Bunkyō City, 113843, Japan
Kaohsiung Veterans General Hospital

Kaohsiung City, 81362, Taiwan
Kianous Stavros

Thessaloniki, 54636, Greece
Kohler and Milsten Research

Mérida, Yucatán, 97070, Mexico
Krakowskie Centrum Medyczne

Krakow, 31501, Poland
Lanzhou University Second Hospital

Pudong, Shanghai Municipality, 200127, China
Latin Clinical Trial Center

San Juan, 00909, Puerto Rico
MICS Centrum Medyczne Bydgoszcz

Bydgoszcz, 85090, Poland
MICS Centrum Medyczne Warszawa

Warsaw, Masovian Voivodeship, 00-874, Poland
Medical Center Medtech Services EOOD

Haskovo, 6304, Bulgaria
Medicover Munchen Ost MVZ

München, Bavaria, 81667, Germany
Oaxaca Site Management Organization

Oaxaca City, 68000, Mexico
Oklahoma Medical Research Foundation

Oklahoma City, Oklahoma, 73104-5005, United States
Olympion General Clinic

Pátrai, 26443, Greece
Onsite Clinical Solutions

Salisbury, North Carolina, 28144, United States
Onyx Clinical Research

Peoria, Arizona, 85381, United States
Orthoillinois

Rockford, Illinois, 61114, United States
Ospedale Policlinico San Martino IRCCS

Genova, 16132, Italy
Ospedale San Giovanni Bosco

Torino, 10154, Italy
PanAmerican Clinical Research

Guadalajara, Jalisco, 44670, Mexico
Panorama Medical Centre

Cape Town, 7500, South Africa
Peking University People's Hospital

Beijing, Beijing Municipality, 100044, China
Penn State - Hershey Medical Center

Hershey, Pennsylvania, 17033, United States
Policlinico Universitario Campus Biomedico Di Roma

Roma, 00128, Italy
Pracownia Badan Klinicznych Salus

Wroclaw, 50570, Poland
Prime Clinical Research - Lewisville

Lewisville, Texas, 75067, United States
Prime Clinical Research - Mansfield

Mansfield, Texas, 76063, United States
Prolato Clinical Research Center (PCRC)

Houston, Texas, 77054, United States
Prywatna Praktyka Lekarska Prof Hab Med Pawel Hrycaj

Poznan, Greater Poland Voivodeship, 61-397, Poland
Renji Hospital, Shanghai Jiaotong University School of Medicine

Shanghai, Shanghai Municipality, 200001, China
Revive Research Institute - Sterling Heights

Sterling Heights, Michigan, 48313, United States
Richmond Clinical Trials

Richmond, British Columbia, V6V 2L1, Canada
Riverside Professional Centre

Sydney, Nova Scotia, B1S 3N1, Canada
SOMED CR

Lodz, 05260, Poland
SPZOZ Uniwersytecki Szpital Kliniczny nr 1 im Norberta Barlickiego Uniwersytetu Medycznego w Lodzi

Lodz, 90153, Poland
SUNY Upstate Medical University

Syracuse, New York, 13210, United States
Shanxi Bethune Hospital

Taiyuan, 030032, China
Shenzhen People's Hospital

Shenzhen, Guangdong, 518020, China
Sierra Pacific Arthritis and Rheumatology Centers

Fresno, California, 93710, United States
Sjaellands Universitetshospital, Koge

Køge, 4600, Denmark
Solace Clinical Research

Tustin, California, 92780, United States
Taipei Medical University Hospital

Taipei, 110, Taiwan
Taipei Veterans General Hospital

Taipei, 1121, Taiwan
The First Affiliated Hospital of Ziamen University

Xiamen, 361003, China
The First Affiliated Hospital, Sun Yat-sen University

Guangzhou, Guangdong, 510060, China
The Second Affiliated Hospital of Nanchang University

Nanchang, Jiangx, 330008, China
The Second Affiliated Hospital of Soochow University

Suzhou, 215025, China
The Second Hospital of Hebei Medical University

Shijiazhuang, Hebei, 050005, China
ULS da Arrábida, E.P.E. - Hospital de São Bernardo

Setúbal, 2910-446, Portugal
ULS de Santa Maria, EPE - Hospital de Santa Maria

Lisbon, 1649-035, Portugal
UMass Chan Medical School

Worcester, Massachusetts, 01655, United States
UZ Leuven

Leuven, 3000, Belgium
Uniklinik Koln

Cologne, 50937, Germany
University General Hospital of Heraklion

Heraklion, 71500, Greece
University Multiprofile Hospital for Active Treatment "Eurohospital Plovdiv"

Plovdiv, 4004, Bulgaria
University of California, Los Angeles

Los Angeles, California, 90024, United States
University of California, San Diego

La Jolla, California, 92037, United States
Velocity Clinical Research

St Louis, Missouri, 63131, United States
Willow Rheumatology and Wellness

Willowbrook, Illinois, 60527, United States
Yale University

New Haven, Connecticut, 06520, United States

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