New obesity drug's brain-body connection revealed in imaging study

NCT ID NCT05202353

First seen Oct 01, 2025 · Last updated May 20, 2026 · Updated 30 times

Summary

This early-stage study tests a new medicine, BI 456906, in 30 adults with obesity. It uses special scans to see how the drug attaches to receptors in the liver and pancreas that control appetite and weight. Participants receive either BI 456906 or the approved weight-loss drug semaglutide for 17 weeks. The goal is to understand how well the new drug targets these receptors, not to measure weight loss directly.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Amsterdam UMC, location VUMC

    RECRUITING

    Amsterdam, 1105 AZ, Netherlands

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.