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A laser microscope may let doctors see skin lesions without cutting

NCT ID NCT01771718

Diagnosis Sponsor: University of California, Irvine Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
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Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 31, 2026 · Last updated Sep 01, 2026 · Updated 1 time

Summary

Researchers at the University of California, Irvine are testing a device that uses multiphoton microscopy to image skin lesions without cutting the skin. The study will enroll 250 people with pigmented or non-pigmented skin lesions. The goal is to see if this non-invasive optical biopsy can capture high-resolution images that reveal the microscopic structure of the skin. If successful, this approach could help doctors understand skin lesions better and potentially reduce the need for surgical biopsies.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Multiphoton microscopy-based tomograph, a non-invasive optical biopsy device
What this could lead to
If it works, this could lead to a non-invasive way to examine skin lesions, potentially reducing the need for surgical biopsies.
What could go wrong
This is an early pilot study, so the imaging may not reliably distinguish between benign and malignant lesions. The technique is also limited to skin surfaces and may not replace traditional biopsy for all cases.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 250 people

The number the study aims to enrol. It can still change while the study runs.

Start date

Apr 2012

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Study population will be selected from University of California Irvine Medical Clinic

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male or Female all age groups * Ability to understand and carry out subject instructions Exclusion Criteria: * Pregnant women

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Skin lesion

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Beckman Laser Institute Medical Clinic

    RECRUITING

    Irvine, California, 92612, United States

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