New depression pill shows promise in Late-Stage trial

NCT ID NCT06058039

Ongoing Symptom relief Sponsor: Neumora Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 06, 2026 · Updated 33 times

Summary

This study tests an experimental oral drug, NMRA-335140, against a placebo in 332 adults with major depressive disorder. Over 6 weeks, researchers measure changes in depression symptoms using a standard rating scale. The goal is to see if the drug can safely reduce depression severity.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Neumora Investigator Site

Cerritos, California, 90703, United States
Neumora Investigator Site

Irvine, California, 92614, United States
Neumora Investigator Site

Long Beach, California, 90807, United States
Neumora Investigator Site

San Diego, California, 92103, United States
Neumora Investigator Site

San Francisco, California, 94107, United States
Neumora Investigator Site

New Haven, Connecticut, 06520, United States
Neumora Investigator Site

Brandon, Florida, 33511, United States
Neumora Investigator Site

Hialeah, Florida, 33012, United States
Neumora Investigator Site

Hialeah, Florida, 33016, United States
Neumora Investigator Site

Jacksonville, Florida, 32256, United States
Neumora Investigator Site

Miami, Florida, 33143, United States
Neumora Investigator Site

Miami, Florida, 33165, United States
Neumora Investigator Site

Miami Beach, Florida, 33140, United States
Neumora Investigator Site

Palm Bay, Florida, 32905, United States
Neumora Investigator Site

Pembroke Pines, Florida, 33024, United States
Neumora Investigator Site

Pompano Beach, Florida, 33060, United States
Neumora Investigator Site

Saint Augustine, Florida, 32086, United States
Neumora Investigator Site

Atlanta, Georgia, 30328, United States
Neumora Investigator Site

Decatur, Georgia, 30030, United States
Neumora Investigator Site

Savannah, Georgia, 31405, United States
Neumora Investigator Site

Springfield, Massachusetts, 01103, United States
Neumora Investigator Site

St Louis, Missouri, 63141, United States
Neumora Investigator Site

Omaha, Nebraska, 68112, United States
Neumora Investigator Site

Berlin, New Jersey, 08009, United States
Neumora Investigator Site

New York, New York, 10029, United States
Neumora Investigator Site

New York, New York, 10036, United States
Neumora Investigator Site

Staten Island, New York, 10310, United States
Neumora Investigator Site

Charlotte, North Carolina, 28211, United States
Neumora Investigator Site

Austin, Texas, 78759, United States
Neumora Investigator Site

DeSoto, Texas, 75115, United States
Neumora Investigator Site

Fort Worth, Texas, 76104, United States
Neumora Investigator Site

Plano, Texas, 75093, United States
Neumora Investigator Site

Cherven Bryag, Pleven, 5980, Bulgaria
Neumora Investigator Site

Sofia, Sofia-Grad, 1408, Bulgaria
Neumora Investigator Site

Sofia, Sofia-Grad, 1463, Bulgaria
Neumora Investigator Site

Sofia, Sofia-Grad, 1680, Bulgaria
Neumora Investigator Site

Kardzhali, 6600, Bulgaria
Neumora Investigator Site

Pleven, 5800, Bulgaria
Neumora Investigator Site

Targovishte, 7700, Bulgaria
Neumora Investigator Site

Varna, 9020, Bulgaria
Neumora Investigator Site

Pilsen, Plzen, 301 00, Czechia
Neumora Investigator Site

Prague, Prague, 186 00, Czechia
Neumora Investigator Site

Kladno, 272 01, Czechia
Neumora Investigator Site

Prague, 109 00, Czechia
Neumora Investigator Site

Helsinki, Etelä-Suomen Lääni, 00100, Finland
Neumora Investigator Site

Turku, Etelä-Suomen Lääni, 20520, Finland
Neumora Investigator Site

Oulu, Oulun Lääni, 90100, Finland
Neumora Investigator Site

Clermont-Ferrand, Auvergne-Rhône-Alpes, 63000, France
Neumora Investigator Site

Douai, Hauts-de-France, 59500, France
Neumora Investigator Site

Montpellier, Hérault, 34295, France
Neumora Investigator Site

Angers, Maine-et-Loire, 49100, France
Neumora Investigator Site

La Roche-sur-Yon, Vendée, 85000, France
Neumora Investigator Site

Poitiers, Vienne, 86000, France
Neumora Investigator Site

Berlin, 10117, Germany
Neumora Investigator Site

Berlin, 10629, Germany
Neumora Investigator Site

Berlin, 13187, Germany
Neumora Investigator Site

Hamburg, 20253, Germany
Neumora Investigator Site

Suchy Las, Greater Poland Voivodeship, 62-002, Poland
Neumora Investigator Site

Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-133, Poland
Neumora Investigator Site

Wroclaw, Lower Silesian Voivodeship, 50-414, Poland
Neumora Investigator Site

Lublin, Lublin Voivodeship, 20-109, Poland
Neumora Investigator Site

Lublin, Lublin Voivodeship, 20-582, Poland
Neumora Investigator Site

Bialystok, Podlaskie Voivodeship, 15-879, Poland
Neumora Investigator Site

Gdansk, Pomeranian Voivodeship, 80-438, Poland
Neumora Investigator Site

Lund, Skåne County, 222 22, Sweden
Neumora Investigator Site

Stockholm, Stockholm County, 113 29, Sweden
Neumora Investigator Site #1

Varna, 9020, Bulgaria
Neumora Investigator Site #1

Kladno, South Bohemian, 272 01, Czechia
Neumora Investigator Site #1

Berlin, 10117, Germany
Neumora Investigator site

Miami, Florida, 33174, United States
Neumora Investigator site

Miami Springs, Florida, 33166, United States

Conditions

Explore the condition pages connected to this study.

MAJOR DEPRESSIVE DISORDER