Double attack on rare cancer: can new drug combo stop deadly Melanoma's return?

NCT ID NCT05111574

Recruiting now Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

Summary

This trial is for people with mucosal melanoma, a rare and aggressive cancer, that has been surgically removed. It tests whether adding a pill called cabozantinib to an immunotherapy drug (nivolumab) is better at preventing the cancer from returning than the immunotherapy alone. The goal is to see if this two-drug combination improves survival and keeps patients cancer-free longer after surgery.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Abbott-Northwestern Hospital
RECRUITING

Minneapolis, Minnesota, 55407, United States

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Alta Bates Summit Medical Center-Herrick Campus
RECRUITING

Berkeley, California, 94704, United States

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Contact Email: •••••@•••••
Asplundh Cancer Pavilion
ACTIVE_NOT_RECRUITING

Willow Grove, Pennsylvania, 19090, United States
Atrium Medical Center-Middletown Regional Hospital
RECRUITING

Franklin, Ohio, 45005-1066, United States

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Avera Cancer Institute
RECRUITING

Sioux Falls, South Dakota, 57105, United States

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BJC Outpatient Center at Sunset Hills
RECRUITING

Sunset Hills, Missouri, 63127, United States

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Beacon Kalamazoo Cancer Center
RECRUITING

Kalamazoo, Michigan, 49009, United States

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Benefis Sletten Cancer Institute
RECRUITING

Great Falls, Montana, 59405, United States

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Billings Clinic Cancer Center
RECRUITING

Billings, Montana, 59101, United States

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Bozeman Health Deaconess Hospital
RECRUITING

Bozeman, Montana, 59715, United States

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Bronson Battle Creek
RECRUITING

Battle Creek, Michigan, 49017, United States

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Bronson Methodist Hospital
RECRUITING

Kalamazoo, Michigan, 49007, United States

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California Pacific Medical Center-Pacific Campus
RECRUITING

San Francisco, California, 94115, United States

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Cancer Care Center of O'Fallon
RECRUITING

O'Fallon, Illinois, 62269, United States

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Cancer Care Specialists of Illinois - Decatur
RECRUITING

Decatur, Illinois, 62526, United States

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Cancer Centers of Southwest Oklahoma Research
RECRUITING

Lawton, Oklahoma, 73505, United States

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Cancer and Hematology Centers of Western Michigan - Norton Shores
RECRUITING

Norton Shores, Michigan, 49444, United States

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Carle Cancer Center
RECRUITING

Urbana, Illinois, 61801, United States

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Carle Physician Group-Effingham
RECRUITING

Effingham, Illinois, 62401, United States

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Carle Physician Group-Mattoon/Charleston
RECRUITING

Mattoon, Illinois, 61938, United States

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Carle at The Riverfront
RECRUITING

Danville, Illinois, 61832, United States

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Case Western Reserve University
RECRUITING

Cleveland, Ohio, 44106, United States

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Centralia Oncology Clinic
RECRUITING

Centralia, Illinois, 62801, United States

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Community Hospital of Anaconda
RECRUITING

Anaconda, Montana, 59711, United States

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Community Medical Center
RECRUITING

Missoula, Montana, 59804, United States

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Corewell Health Grand Rapids Hospitals - Butterworth Hospital
RECRUITING

Grand Rapids, Michigan, 49503, United States

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Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
RECRUITING

Saint Joseph, Michigan, 49085, United States

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Corewell Health Lakeland Hospitals - Niles Hospital
RECRUITING

Niles, Michigan, 49120, United States

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Corewell Health Reed City Hospital
RECRUITING

Reed City, Michigan, 49677, United States

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Crossroads Cancer Center
RECRUITING

Effingham, Illinois, 62401, United States

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Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States

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Dayton Physician LLC - Englewood
ACTIVE_NOT_RECRUITING

Dayton, Ohio, 45415, United States
Decatur Memorial Hospital
RECRUITING

Decatur, Illinois, 62526, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Fairview Southdale Hospital
RECRUITING

Edina, Minnesota, 55435, United States

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Good Samaritan Hospital - Cincinnati
RECRUITING

Cincinnati, Ohio, 45220, United States

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HSHS Sacred Heart Hospital
SUSPENDED

Eau Claire, Wisconsin, 54701, United States
Hematology Oncology Associates of CNY at Camillus
RECRUITING

Camillus, New York, 13031, United States

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Hematology Oncology Associates of Central New York-East Syracuse
RECRUITING

East Syracuse, New York, 13057, United States

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Jewish General Hospital
RECRUITING

Montreal, Quebec, H3T 1E2, Canada

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Keck Medicine of USC Koreatown
RECRUITING

Los Angeles, California, 90020, United States

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Kettering Medical Center
ACTIVE_NOT_RECRUITING

Kettering, Ohio, 45429, United States
Kootenai Clinic Cancer Services - Post Falls
RECRUITING

Post Falls, Idaho, 83854, United States

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Kootenai Clinic Cancer Services - Sandpoint
RECRUITING

Sandpoint, Idaho, 83864, United States

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Kootenai Health - Coeur d'Alene
RECRUITING

Coeur d'Alene, Idaho, 83814, United States

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Laura and Isaac Perlmutter Cancer Center at NYU Langone
RECRUITING

New York, New York, 10016, United States

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Contact Email: •••••@•••••
Logan Health Medical Center
RECRUITING

Kalispell, Montana, 59901, United States

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Los Angeles General Medical Center
RECRUITING

Los Angeles, California, 90033, United States

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M D Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States

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Marshfield Medical Center - Minocqua
RECRUITING

Minocqua, Wisconsin, 54548, United States

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Marshfield Medical Center - Weston
RECRUITING

Weston, Wisconsin, 54476, United States

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Marshfield Medical Center-EC Cancer Center
RECRUITING

Eau Claire, Wisconsin, 54701, United States

Contact

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Marshfield Medical Center-Marshfield
RECRUITING

Marshfield, Wisconsin, 54449, United States

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Marshfield Medical Center-Rice Lake
RECRUITING

Rice Lake, Wisconsin, 54868, United States

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Marshfield Medical Center-River Region at Stevens Point
RECRUITING

Stevens Point, Wisconsin, 54482, United States

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Mary Greeley Medical Center
RECRUITING

Ames, Iowa, 50010, United States

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Mayo Clinic in Rochester
SUSPENDED

Rochester, Minnesota, 55905, United States
McFarland Clinic - Ames
RECRUITING

Ames, Iowa, 50010, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
McFarland Clinic - Boone
SUSPENDED

Boone, Iowa, 50036, United States
McFarland Clinic - Jefferson
SUSPENDED

Jefferson, Iowa, 50129, United States
McFarland Clinic - Marshalltown
RECRUITING

Marshalltown, Iowa, 50158, United States

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McFarland Clinic - Trinity Cancer Center
RECRUITING

Fort Dodge, Iowa, 50501, United States

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Memorial Medical Center
RECRUITING

Modesto, California, 95355, United States

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Contact Email: •••••@•••••
Memorial Sloan Kettering Basking Ridge
RECRUITING

Basking Ridge, New Jersey, 07920, United States

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Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States

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Memorial Sloan Kettering Westchester
RECRUITING

Harrison, New York, 10604, United States

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Mercy Hospital
RECRUITING

Coon Rapids, Minnesota, 55433, United States

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Mercy Medical Center - Des Moines
RECRUITING

Des Moines, Iowa, 50314, United States

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MetroHealth Medical Center
RECRUITING

Cleveland, Ohio, 44109, United States

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Contact Phone: •••-•••-•••• Email: •••••@•••••
Miami Valley Cancer Care and Infusion
RECRUITING

Greenville, Ohio, 45331, United States

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Miami Valley Hospital
RECRUITING

Dayton, Ohio, 45409, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

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Miami Valley Hospital North
RECRUITING

Dayton, Ohio, 45415, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

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Miami Valley Hospital South
RECRUITING

Centerville, Ohio, 45459, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

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Mills Health Center
RECRUITING

San Mateo, California, 94401, United States

Contact

Contact Email: •••••@•••••
Minnesota Oncology - Burnsville
RECRUITING

Burnsville, Minnesota, 55337, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Missouri Baptist Medical Center
RECRUITING

St Louis, Missouri, 63131, United States

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Missouri Baptist Sullivan Hospital
RECRUITING

Sullivan, Missouri, 63080, United States

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Munson Medical Center
RECRUITING

Traverse City, Michigan, 49684, United States

Contact

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NYU Langone Hospital - Long Island
RECRUITING

Mineola, New York, 11501, United States

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North Memorial Medical Health Center
RECRUITING

Robbinsdale, Minnesota, 55422, United States

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Northwell Health/Center for Advanced Medicine
RECRUITING

Lake Success, New York, 11042, United States

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Northwestern Medicine Cancer Center Delnor
RECRUITING

Geneva, Illinois, 60134, United States

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Northwestern Medicine Cancer Center Kishwaukee
RECRUITING

DeKalb, Illinois, 60115, United States

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Northwestern Medicine Cancer Center Warrenville
RECRUITING

Warrenville, Illinois, 60555, United States

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Northwestern Medicine Glenview Outpatient Center
RECRUITING

Glenview, Illinois, 60026, United States

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Northwestern Medicine Grayslake Outpatient Center
RECRUITING

Grayslake, Illinois, 60030, United States

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Northwestern Medicine Lake Forest Hospital
RECRUITING

Lake Forest, Illinois, 60045, United States

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Northwestern Medicine Orland Park
RECRUITING

Orland Park, Illinois, 60462, United States

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Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States

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Contact Phone: •••-•••-•••• Email: •••••@•••••
Odette Cancer Centre- Sunnybrook Health Sciences Centre
RECRUITING

Toronto, Ontario, M4N 3M5, Canada

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Ottawa Hospital and Cancer Center-General Campus
RECRUITING

Ottawa, Ontario, K1H 8L6, Canada

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Palo Alto Medical Foundation Health Care
SUSPENDED

Palo Alto, California, 94301, United States
Palo Alto Medical Foundation-Fremont
RECRUITING

Fremont, California, 94538, United States

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Contact Email: •••••@•••••
Palo Alto Medical Foundation-Santa Cruz
RECRUITING

Santa Cruz, California, 95065, United States

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Contact Email: •••••@•••••
Palo Alto Medical Foundation-Sunnyvale
RECRUITING

Sunnyvale, California, 94086, United States

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Contact Email: •••••@•••••
Park Nicollet Clinic - Saint Louis Park
RECRUITING

Saint Louis Park, Minnesota, 55416, United States

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Contact Phone: •••-•••-•••• Email: •••••@•••••
Parkland Health Center - Farmington
RECRUITING

Farmington, Missouri, 63640, United States

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Premier Blood and Cancer Center
RECRUITING

Dayton, Ohio, 45409, United States

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Contact
Rapid City Regional Hospital
ACTIVE_NOT_RECRUITING

Rapid City, South Dakota, 57701, United States
Regions Hospital
RECRUITING

Saint Paul, Minnesota, 55101, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Rush-Copley Healthcare Center
RECRUITING

Yorkville, Illinois, 60560, United States

Contact

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Rush-Copley Medical Center
RECRUITING

Aurora, Illinois, 60504, United States

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Saint Alphonsus Cancer Care Center-Boise
SUSPENDED

Boise, Idaho, 83706, United States
Saint Alphonsus Cancer Care Center-Caldwell
SUSPENDED

Caldwell, Idaho, 83605, United States
Saint Alphonsus Cancer Care Center-Nampa
SUSPENDED

Nampa, Idaho, 83687, United States
Saint Alphonsus Cancer Care Center-Ontario
SUSPENDED

Ontario, Oregon, 97914, United States
Saint Vincent Hospital Cancer Center Green Bay
RECRUITING

Green Bay, Wisconsin, 54301, United States

Contact

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Saint Vincent Hospital Cancer Center at Oconto Falls
RECRUITING

Oconto Falls, Wisconsin, 54154, United States

Contact

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Saint Vincent Hospital Cancer Center at Saint Mary's
RECRUITING

Green Bay, Wisconsin, 54303, United States

Contact

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Saint Vincent Hospital Cancer Center at Sheboygan
RECRUITING

Sheboygan, Wisconsin, 53081, United States

Contact

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Saint Vincent Hospital Cancer Center at Sturgeon Bay
RECRUITING

Sturgeon Bay, Wisconsin, 54235-1495, United States

Contact

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Sainte Genevieve County Memorial Hospital
RECRUITING

Sainte Genevieve, Missouri, 63670, United States

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Contact Phone: •••-•••-••••
Southern Illinois University School of Medicine
RECRUITING

Springfield, Illinois, 62702, United States

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Springfield Clinic
RECRUITING

Springfield, Illinois, 62702, United States

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Springfield Memorial Hospital
RECRUITING

Springfield, Illinois, 62781, United States

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Contact Phone: •••-•••-•••• Email: •••••@•••••
Stanford Cancer Institute Palo Alto
SUSPENDED

Palo Alto, California, 94304, United States
Sutter Auburn Faith Hospital
RECRUITING

Auburn, California, 95602, United States

Contact

Contact Email: •••••@•••••
Sutter Medical Center Sacramento
RECRUITING

Sacramento, California, 95816, United States

Contact

Contact Email: •••••@•••••
Sutter Pacific Medical Foundation
RECRUITING

Santa Rosa, California, 95403, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Sutter Roseville Medical Center
RECRUITING

Roseville, California, 95661, United States

Contact

Contact Email: •••••@•••••
Sutter Solano Medical Center/Cancer Center
RECRUITING

Vallejo, California, 94589, United States

Contact

Contact Email: •••••@•••••
The Melanoma and Skin Cancer Institute
ACTIVE_NOT_RECRUITING

Englewood, Colorado, 80113, United States
Thomas Jefferson University Hospital
ACTIVE_NOT_RECRUITING

Philadelphia, Pennsylvania, 19107, United States
Trinity Health Grand Rapids Hospital
RECRUITING

Grand Rapids, Michigan, 49503, United States

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Contact Phone: •••-•••-•••• Email: •••••@•••••
Trinity Health Muskegon Hospital
RECRUITING

Muskegon, Michigan, 49444, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
UCSF Medical Center-Mission Bay
SUSPENDED

San Francisco, California, 94158, United States
UI Health Care Mission Cancer and Blood - Ankeny Clinic
RECRUITING

Ankeny, Iowa, 50023, United States

Contact

Contact Phone: •••-•••-••••
UI Health Care Mission Cancer and Blood - Laurel Clinic
RECRUITING

Des Moines, Iowa, 50314, United States

Contact

Contact Phone: •••-•••-••••
UI Health Care Mission Cancer and Blood - Waukee Clinic
RECRUITING

Waukee, Iowa, 50263, United States

Contact

Contact Phone: •••-•••-••••
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
RECRUITING

Clive, Iowa, 50325, United States

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Contact Phone: •••-•••-••••
UM Sylvester Comprehensive Cancer Center at Aventura
ACTIVE_NOT_RECRUITING

Aventura, Florida, 33180, United States
UM Sylvester Comprehensive Cancer Center at Coral Gables
ACTIVE_NOT_RECRUITING

Coral Gables, Florida, 33146, United States
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
ACTIVE_NOT_RECRUITING

Deerfield Beach, Florida, 33442, United States
UM Sylvester Comprehensive Cancer Center at Plantation
ACTIVE_NOT_RECRUITING

Plantation, Florida, 33324, United States
USC / Norris Comprehensive Cancer Center
RECRUITING

Los Angeles, California, 90033, United States

Contact

Contact Phone: •••-•••-••••
USC Norris Oncology/Hematology-Newport Beach
RECRUITING

Newport Beach, California, 92663, United States

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Contact Phone: •••-•••-••••
United Hospital
RECRUITING

Saint Paul, Minnesota, 55102, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
University Health Network-Princess Margaret Hospital
RECRUITING

Toronto, Ontario, M5G 2M9, Canada

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Miami Miller School of Medicine-Sylvester Cancer Center
ACTIVE_NOT_RECRUITING

Miami, Florida, 33136, United States
University of Michigan Health - West
RECRUITING

Wyoming, Michigan, 49519, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Pittsburgh Cancer Institute (UPCI)
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States

Contact Phone: •••-•••-••••

Contact
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
RECRUITING

Madison, Wisconsin, 53718, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
University of Wisconsin Carbone Cancer Center - University Hospital
RECRUITING

Madison, Wisconsin, 53792, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Upper Valley Medical Center
RECRUITING

Troy, Ohio, 45373, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
VCU Massey Cancer Center at Stony Point
RECRUITING

Richmond, Virginia, 23235, United States

Contact

Contact Email: •••••@•••••
VCU Massey Comprehensive Cancer Center
RECRUITING

Richmond, Virginia, 23298, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
West Michigan Cancer Center
RECRUITING

Kalamazoo, Michigan, 49007, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.

ANAL MELANOMA BLADDER MELANOMA CERVICAL MELANOMA ESOPHAGEAL MELANOMA GALLBLADDER MELANOMA HEAD AND NECK MUCOSAL MELANOMA MUCOSAL MELANOMA NASOPHARYNGEAL MUCOSAL MELANOMA ORAL CAVITY MUCOSAL MELANOMA PENILE MUCOSAL MELANOMA RECTAL MELANOMA RECURRENT MUCOSAL MELANOMA SINONASAL MUCOSAL MELANOMA URETHRAL MELANOMA URINARY SYSTEM MUCOSAL MELANOMA VAGINAL MELANOMA VULVAR MELANOMA