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Drug aims to stop deadly skin cancer's comeback after surgery

NCT ID NCT04099251

Ongoing Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

First seen Apr 11, 2026 · Last updated Apr 11, 2026

Summary

This study is testing whether a drug called nivolumab can help prevent melanoma skin cancer from coming back after it has been surgically removed. It involves about 790 people with a high-risk form of melanoma who have had all visible cancer removed by surgery. Participants are randomly assigned to receive either the real drug or a placebo (inactive substance) to see which group stays cancer-free longer.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Local Institution - 0001

    Groningen, 9700RB, Netherlands

  • Local Institution - 0002

    Utrecht, 3584 CX, Netherlands

  • Local Institution - 0003

    Linköping, Östergötlands Län [se-05], 581 85, Sweden

  • Local Institution - 0005

    Oslo, 0310, Norway

  • Local Institution - 0007

    Aarhus N, 8200, Denmark

  • Local Institution - 0008

    Kortrijk, 8500, Belgium

  • Local Institution - 0010

    Liège, 4000, Belgium

  • Local Institution - 0011

    Ghent, 9000, Belgium

  • Local Institution - 0012

    Herlev, 2730, Denmark

  • Local Institution - 0013

    Odense, 5000, Denmark

  • Local Institution - 0014

    Helsinki, Etelä-Suomen Lääni, 00290, Finland

  • Local Institution - 0015

    Tampere, Pirkanmaa, 33520, Finland

  • Local Institution - 0016

    Wollstonecraft, New South Wales, 2065, Australia

  • Local Institution - 0017

    Greenslopes, Queensland, 4120, Australia

  • Local Institution - 0018

    Waratah, New South Wales, 2298, Australia

  • Local Institution - 0019

    Box Hill, Victoria, 3128, Australia

  • Local Institution - 0020

    Craiova, 200542, Romania

  • Local Institution - 0021

    Sector 2, 022328, Romania

  • Local Institution - 0022

    Warsaw, 02-781, Poland

  • Local Institution - 0023

    Gdansk, 80-214, Poland

  • Local Institution - 0024

    Herston, Queensland, 4029, Australia

  • Local Institution - 0025

    Westmead, New South Wales, 2145, Australia

  • Local Institution - 0026

    Örebro, 701 85, Sweden

  • Local Institution - 0027

    Grålum, 1714, Norway

  • Local Institution - 0028

    Charleroi, 6000, Belgium

  • Local Institution - 0030

    Rotterdam, 3015 AA, Netherlands

  • Local Institution - 0031

    Pittsburgh, Pennsylvania, 15232, United States

  • Local Institution - 0032

    Pierre-Bénite, 69495, France

  • Local Institution - 0033

    Marseille, 13011, France

  • Local Institution - 0034

    Villejuif, 94800, France

  • Local Institution - 0035

    Nantes, 44000, France

  • Local Institution - 0036

    Paris, 75475, France

  • Local Institution - 0037

    Milan, 20133, Italy

  • Local Institution - 0038

    Siena, 53100, Italy

  • Local Institution - 0039

    Padova, 35128, Italy

  • Local Institution - 0040

    Bergamo, 24127, Italy

  • Local Institution - 0044

    Cardiff, CF14 2TL, United Kingdom

  • Local Institution - 0046

    Palermo, Sicily, 90127, Italy

  • Local Institution - 0047

    Cluj-Napoca, 400015, Romania

  • Local Institution - 0048

    Vienna, 1090, Austria

  • Local Institution - 0049

    Graz, 8036, Austria

  • Local Institution - 0050

    Salzburg, 5020, Austria

  • Local Institution - 0051

    Innsbruck, 6020, Austria

  • Local Institution - 0052

    Zurich, 8091, Switzerland

  • Local Institution - 0053

    Lausanne, 1011, Switzerland

  • Local Institution - 0054

    Essen, 45122, Germany

  • Local Institution - 0055

    Heidelberg, 69120, Germany

  • Local Institution - 0056

    München, Bavaria, 81377, Germany

  • Local Institution - 0057

    Lübeck, 23538, Germany

  • Local Institution - 0058

    Tübingen, 72076, Germany

  • Local Institution - 0060

    Hanover, 30625, Germany

  • Local Institution - 0061

    Buxtehude, 21614, Germany

  • Local Institution - 0062

    Gera, 07548, Germany

  • Local Institution - 0063

    Bergen, 5021, Norway

  • Local Institution - 0064

    Santander, 39008, Spain

  • Local Institution - 0065

    Badalona, 08916, Spain

  • Local Institution - 0066

    Madrid, 28034, Spain

  • Local Institution - 0067

    A Coruña, 15006, Spain

  • Local Institution - 0068

    Málaga, 29010, Spain

  • Local Institution - 0069

    Valencia, 46009, Spain

  • Local Institution - 0070

    Madrid, 28046, Spain

  • Local Institution - 0071

    Barcelona, Barcelona [Barcelona], 08028, Spain

  • Local Institution - 0072

    Bonn, 53127, Germany

  • Local Institution - 0073

    Prague, 100 34, Czechia

  • Local Institution - 0074

    Prague, Praha 2, 12808, Czechia

  • Local Institution - 0075

    Ostrava-Poruba, 708 52, Czechia

  • Local Institution - 0076

    Portland, Oregon, 97213, United States

  • Local Institution - 0077

    San Francisco, California, 94115, United States

  • Local Institution - 0078

    Boston, Massachusetts, 02215, United States

  • Local Institution - 0079

    Omaha, Nebraska, 68130, United States

  • Local Institution - 0080

    Los Angeles, California, 90025, United States

  • Local Institution - 0081

    Robbinsdale, Minnesota, 55407, United States

  • Local Institution - 0082

    Athens, 115 27, Greece

  • Local Institution - 0083

    Thessaloniki, 57100, Greece

  • Local Institution - 0084

    Athens, Attikí, 185 47, Greece

  • Local Institution - 0085

    Dallas, Texas, 75246, United States

  • Local Institution - 0086

    Charlotte, North Carolina, 28204, United States

  • Local Institution - 0087

    Springdale, Arkansas, 72762, United States

  • Local Institution - 0088

    Birmingham, Alabama, 35294-3300, United States

  • Local Institution - 0089

    Washington D.C., District of Columbia, 20057, United States

  • Local Institution - 0090

    Fairfax, Virginia, 22031, United States

  • Local Institution - 0091

    Aurora, Colorado, 80045, United States

  • Local Institution - 0092

    Allentown, Pennsylvania, 18103, United States

  • Local Institution - 0093

    Hackensack, New Jersey, 07601, United States

  • Local Institution - 0094

    New York, New York, 10016, United States

  • Local Institution - 0095

    Southampton, SO16 6YD, United Kingdom

  • Local Institution - 0098

    Dresden, 01307, Germany

  • Local Institution - 0099

    Cleveland, Ohio, 44195, United States

  • Local Institution - 0100

    Mainz, 55131, Germany

  • Local Institution - 0101

    Naples, 80131, Italy

  • Local Institution - 0102

    Regensburg, 93053, Germany

  • Local Institution - 0103

    Poznan, Greater Poland Voivodeship, 60-569, Poland

  • Local Institution - 0104

    Nedlands, Western Australia, 6009, Australia

  • Local Institution - 0105

    Cairns, Queensland, 4870, Australia

  • Local Institution - 0106

    Melbourne, Victoria, 3004, Australia

  • Local Institution - 0107

    Breda, 4819 EV, Netherlands

  • Local Institution - 0109

    Vallejo, California, 94589, United States

  • Local Institution - 0110

    Turku, 20251, Finland

  • Local Institution - 0111

    Lille, 59037, France

  • Local Institution - 0112

    Bordeaux, 33075, France

  • Local Institution - 0113

    Brest, Finistère, 29200, France

  • Local Institution - 0114

    Göttingen, 37075, Germany

  • Local Institution - 0116

    Montreal, Quebec, H2X 3E4, Canada

  • Local Institution - 0119

    San Francisco, California, 94115, United States

  • Local Institution - 0120

    Vallejo, California, 94589, United States

  • Local Institution - 0121

    Vallejo, California, 94589-2441, United States

  • Local Institution - 0122

    San Jose, California, 95119, United States

  • Local Institution - 0123

    Sherbrooke, Quebec, J1H 5N4, Canada

  • Local Institution - 0124

    Kingston, Ontario, K7L 2V7, Canada

  • Local Institution - 0125

    Geelong, Victoria, 3220, Australia

  • Local Institution - 0126

    Tucson, Arizona, 85724-5024, United States

  • Local Institution - 0127

    Boston, Massachusetts, 02215, United States

  • Local Institution - 0128

    Malvern, Victoria, 3144, Australia

  • Local Institution - 0129

    Besançon, 25030, France

  • Local Institution - 0130

    Nice, 06200, France

  • Local Institution - 0131

    Halifax, Nova Scotia, B3H 2Y9, Canada

  • Local Institution - 0132

    Chicago, Illinois, 60611, United States

  • Local Institution - 0133

    Vancouver, British Columbia, V5Z 4E6, Canada

  • Local Institution - 0134

    Calgary, Alberta, T2N 4N2, Canada

  • Local Institution - 0135

    Baltimore, Maryland, 21237, United States

  • Local Institution - 0138

    Southport, Queensland, 4120, Australia

  • Local Institution - 0140

    Toronto, Ontario, M5G 2M9, Canada

  • Local Institution - 0141

    Atlanta, Georgia, 30342, United States

  • Local Institution - 0142

    Hamilton, Ontario, L8V 5C2, Canada

  • Local Institution - 0143

    Boston, Massachusetts, 02215, United States

  • Local Institution - 0144

    Austin, Texas, 78731, United States

  • Local Institution - 0145

    Perugia, 06132, Italy

  • Local Institution - 0146

    Milan, 20141, Italy

  • Local Institution - 0148

    Germantown, Tennessee, 38138, United States

  • Local Institution - 0151

    Minneapolis, Minnesota, 55407, United States

Conditions

Explore the condition pages connected to this study.

MELANOMA