Drug shows promise in keeping aggressive esophageal cancer at bay after treatment

NCT ID NCT02743494

Completed Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

Summary

This large, completed Phase 3 trial tested whether the immunotherapy drug nivolumab could help prevent cancer from returning in patients who had surgery for esophageal or gastroesophageal junction cancer. The study involved 794 patients who had already completed chemotherapy and radiation before surgery but still had a high risk of the cancer coming back. Participants received either nivolumab or a placebo (inactive treatment) after surgery to see which group stayed cancer-free longer.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Local Institution - 0001

Mainz, Rhineland-Palatinate, 55131, Germany
Local Institution - 0003

Cologne, 50937, Germany
Local Institution - 0005

Munich, 81675, Germany
Local Institution - 0006

Berlin, D-13353, Germany
Local Institution - 0007

Hamburg, 20251, Germany
Local Institution - 0008

Essen, 45136, Germany
Local Institution - 0011

Tübingen, 72076, Germany
Local Institution - 0012

Houston, Texas, 77030-4009, United States
Local Institution - 0017

Marburg, 35043, Germany
Local Institution - 0018

Basel, 4031, Switzerland
Local Institution - 0022

Pensacola, Florida, 32504, United States
Local Institution - 0023

San Francisco, California, 94115, United States
Local Institution - 0024

Durham, North Carolina, 27710, United States
Local Institution - 0025

Baltimore, Maryland, 21202, United States
Local Institution - 0026

Los Angeles, California, 90033, United States
Local Institution - 0027

St Louis, Missouri, 63110, United States
Local Institution - 0028

Craiova, 200347, Romania
Local Institution - 0029

Hradec Králové, 500 05, Czechia
Local Institution - 0030

Olomouc, 779 00, Czechia
Local Institution - 0031

Brno, 656 53, Czechia
Local Institution - 0032

New York, New York, 10016, United States
Local Institution - 0033

Charlotte, North Carolina, 28262, United States
Local Institution - 0034

Leuven, 3000, Belgium
Local Institution - 0035

Brussels, 1200, Belgium
Local Institution - 0036

Liège, 4000, Belgium
Local Institution - 0037

Edegem, 2650, Belgium
Local Institution - 0038

Galway, Ireland
Local Institution - 0039

Wilton, CORK, 0, Ireland
Local Institution - 0040

Dublin, 9, Ireland
Local Institution - 0042

Groningen, 9713 AP, Netherlands
Local Institution - 0043

Maastrict, 6229 HX, Netherlands
Local Institution - 0045

London, Greater London, SW3 6JJ, United Kingdom
Local Institution - 0046

Southampton, Hampshire, SO16 6YD, United Kingdom
Local Institution - 0047

Sankt Gallen, 9007, Switzerland
Local Institution - 0048

Philadelphia, Pennsylvania, 19111, United States
Local Institution - 0049

Withington, Manchester, M20 4BX, United Kingdom
Local Institution - 0050

Capital Federal, Buenos Aires, 1264, Argentina
Local Institution - 0051

San Miguel de Tucumán, Tucumán Province, 4000, Argentina
Local Institution - 0052

Debrecen, 0, Hungary
Local Institution - 0053

Budapest, 1097, Hungary
Local Institution - 0054

Washington D.C., District of Columbia, 20007, United States
Local Institution - 0055

Boston, Massachusetts, 02215, United States
Local Institution - 0056

Cleveland, Ohio, 44106, United States
Local Institution - 0057

Kaposvár, 7400, Hungary
Local Institution - 0058

Hackensack, New Jersey, 07601, United States
Local Institution - 0059

Ijuí, Rio Grande do Sul, 98700-000, Brazil
Local Institution - 0060

Porto Alegre, Rio Grande do Sul, 90610-000, Brazil
Local Institution - 0061

Barretos, São Paulo, 14780-070, Brazil
Local Institution - 0062

São Paulo, 01246-000, Brazil
Local Institution - 0063

São Paulo, 01308-050, Brazil
Local Institution - 0064

Salvador, 0, Brazil
Local Institution - 0065

Rio de Janeiro, 22793-080, Brazil
Local Institution - 0066

Neptune City, New Jersey, 07753, United States
Local Institution - 0067

Seattle, Washington, 98109, United States
Local Institution - 0068

San Francisco, California, 94158, United States
Local Institution - 0069

Madison, Wisconsin, 53792, United States
Local Institution - 0072

Clayton, Victoria, 3168, Australia
Local Institution - 0074

St Leonards, New South Wales, 2065, Australia
Local Institution - 0075

Tamworth, New South Wales, 2340, Australia
Local Institution - 0077

Madrid, 28050, Spain
Local Institution - 0078

Barcelona, 08035, Spain
Local Institution - 0079

Córdoba, 14004, Spain
Local Institution - 0080

Madrid, 28007, Spain
Local Institution - 0081

Warsaw, 02-781, Poland
Local Institution - 0082

Poznan, 60-780, Poland
Local Institution - 0083

Gliwice, 44-101, Poland
Local Institution - 0084

Distrito Federal, 14080, Mexico
Local Institution - 0085

Tlalpan, Distrito Federal C.p., 14000, Mexico
Local Institution - 0086

Ghent, 9000, Belgium
Local Institution - 0087

Namur, 5000, Belgium
Local Institution - 0088

Lima, LIMA 41, Peru
Local Institution - 0089

Amsterdam, North Holland, 1066 CX, Netherlands
Local Institution - 0091

Ottawa, Ontario, K1H 8L6, Canada
Local Institution - 0092

Halifax, Nova Scotia, B3H 1V7, Canada
Local Institution - 0093

Vancouver, British Columbia, V5Z 4E6, Canada
Local Institution - 0094

London, Ontario, N6A 4L6, Canada
Local Institution - 0095

Brasília, Federal District, 70200-730, Brazil
Local Institution - 0096

Belo Horizonte, Minas Gerais, 30130-090, Brazil
Local Institution - 0097

San Juan, 00927, Puerto Rico
Local Institution - 0098

Gosford, New South Wales, 2250, Australia
Local Institution - 0099

Hobart, 7000, Australia
Local Institution - 0101

Allentown, Pennsylvania, 18103, United States
Local Institution - 0103

Cluj-Napoca, 400352, Romania
Local Institution - 0104

Milan, 20133, Italy
Local Institution - 0105

Bergamo, 24127, Italy
Local Institution - 0106

Reggio Emilia, 42100, Italy
Local Institution - 0107

Roma, 00168, Italy
Local Institution - 0109

Québec, Quebec, G1R 2J6, Canada
Local Institution - 0110

Toronto, Ontario, M5G 2M9, Canada
Local Institution - 0111

Nashville, Tennessee, 37203, United States
Local Institution - 0112

Córdoba, X5006HBF, Argentina
Local Institution - 0113

Fort Myers, Florida, 33901, United States
Local Institution - 0114

St. Petersburg, Florida, 33705, United States
Local Institution - 0116

Pittsburgh, Pennsylvania, 15212, United States
Local Institution - 0117

Lille, 59037, France
Local Institution - 0118

Pierre-Bénite, 69495, France
Local Institution - 0119

Paris, 75012, France
Local Institution - 0120

Pessac, 33604, France
Local Institution - 0121

Dijon, 21079, France
Local Institution - 0123

Adelaide, South Australia, 5000, Australia
Local Institution - 0125

Moscow, 115478, Russia
Local Institution - 0127

Leon, Guanajato, Guanajuato, 37000, Mexico
Local Institution - 0129

Edmonton, Alberta, T6G 1Z2, Canada
Local Institution - 0130

Nashville, Tennessee, 37232, United States
Local Institution - 0131

Jacksonville, Florida, 32256, United States
Local Institution - 0132

Rennes, 35033, France
Local Institution - 0133

CABA, 1426, Argentina
Local Institution - 0134

Montreal, Quebec, H4A 3J1, Canada
Local Institution - 0135

Floreşti, 407280, Romania
Local Institution - 0136

Saint Petersburg, 197758, Russia
Local Institution - 0137

Milan, 20097, Italy
Local Institution - 0138

Krakow, 31-202, Poland
Local Institution - 0139

Lublin, 20-081, Poland
Local Institution - 0140

Kanwal, New South Wales, 2263, Australia
Local Institution - 0141

Lima, LIMA 31, Peru
Local Institution - 0142

Tel Aviv, 64239, Israel
Local Institution - 0143

Petah Tikva, 49100, Israel
Local Institution - 0144

Jerusalem, 91120, Israel
Local Institution - 0145

Ramat Gan, 52621, Israel
Local Institution - 0146

Haifa, 31096, Israel
Local Institution - 0148

Toulouse, 31403, France
Local Institution - 0149

Rouen, 76000, France
Local Institution - 0151

Aurora, Colorado, 80045, United States
Local Institution - 0152

Capital Federal, Buenos Aires, 1280, Argentina
Local Institution - 0153

Chicago, Illinois, 60637, United States
Local Institution - 0154

Aguascalientes, 20230, Mexico
Local Institution - 0156

Perth, Western Australia, 6150, Australia
Local Institution - 0157

Istanbul, 34300, Turkey (Türkiye)
Local Institution - 0160

Adana, 01250, Turkey (Türkiye)
Local Institution - 0161

Erzurum, 25240, Turkey (Türkiye)
Local Institution - 0162

Lima, 34, Peru
Local Institution - 0163

Bucharest, 022328, Romania
Local Institution - 0164

Ciudad Autonoma Buenos Aires, Distrito Federal, 1118, Argentina
Local Institution - 0165

Portland, Oregon, 97239, United States
Local Institution - 0166

Aarhus N, Central Jutland, 8200, Denmark
Local Institution - 0167

Baia Mare, 430295, Romania
Local Institution - 0168

Mexico City, 06760, Mexico
Local Institution - 0169

Sutton, Surrey, SM2 5PT, United Kingdom
Local Institution - 0170

Boston, Massachusetts, 02215, United States
Local Institution - 0171

Boston, Massachusetts, 02215, United States
Local Institution - 0172

Chuo-ku, Tokyo, 1040045, Japan
Local Institution - 0173

Akita, Akita, 0108543, Japan
Local Institution - 0174

Minato-ku, Tokyo, 1058470, Japan
Local Institution - 0175

Songpa-gu, Seoul, 05505, South Korea
Local Institution - 0176

Seoul, 120-752, South Korea
Local Institution - 0177

Taichung, 40447, Taiwan
Local Institution - 0178

Tainan, 70403, Taiwan
Local Institution - 0179

Taipei, 100, Taiwan
Local Institution - 0180

Chiba, Chiba, 2608677, Japan
Local Institution - 0181

Kita-gun, 7610793, Japan
Local Institution - 0182

Sayama, Osaka, 589-8511, Japan
Local Institution - 0183

Hiroshima, Hiroshima, 7348551, Japan
Local Institution - 0184

Kumamoto, Kumamoto, 8608556, Japan
Local Institution - 0185

Suita-shi, Osaka, 565-0871, Japan
Local Institution - 0186

Kitaadachi-gun, Saitama, 3620806, Japan
Local Institution - 0187

Fukuoka, Fukuoka, 8128582, Japan
Local Institution - 0188

Sendai, Miyagi, 9808574, Japan
Local Institution - 0189

Gifu, Gifu, 5011194, Japan
Local Institution - 0190

Koto-ku, Tokyo, 1358550, Japan
Local Institution - 0191

Kagoshima, Kagoshima-ken, 8908520, Japan
Local Institution - 0192

Sapporo, Hokkaido, 0030027, Japan
Local Institution - 0193

Shinjuku-ku, Tokyo, 1600023, Japan
Local Institution - 0194

Fukuoka, 8111395, Japan
Local Institution - 0195

Callao, 02, Peru
Local Institution - 0196

Sapporo, Hokkaido, 0608648, Japan
Local Institution - 0197

Bucharest, 021389, Romania
Local Institution - 0198

Buenos Aires, 1093 AAS, Argentina
Local Institution - 0200

Blacktown, New South Wales, 2148, Australia
Local Institution - 0202

London, SE1 9RT, United Kingdom
Local Institution - 0203

London, Greater London, NW1 2PG, United Kingdom
Local Institution - 0204

Shinjuuku-ku, Tokyo, 1608582, Japan
Local Institution - 0205

The Bronx, New York, 10461, United States
Local Institution - 0207

Viedma, Río Negro Province, 8500, Argentina
Local Institution - 0208

Rosario, Santa Fe Province, 2000, Argentina
Local Institution - 0209

Saint Petersburg, 197022, Russia
Local Institution - 0212

Tuxtla Gutiérrez, Chiapas, 29038, Mexico
Local Institution - 0213

Cheboksary, 428020, Russia
Local Institution - 0214

Trois-Rivières, Quebec, G8Z 3R9, Canada
Local Institution - 0215

Avignon Cedes 9, 84918, France
Local Institution - 0216

Dallas, Texas, 75216, United States
Local Institution - 0217

Boston, Massachusetts, 02215, United States
Local Institution - 0218

Singapore, 119228, Singapore
Local Institution - 0219

Singapore, Central Singapore, 168583, Singapore
Local Institution - 0221

Curitiba, Paraná, 81520-060, Brazil
Local Institution - 0222

Sao Jose de Rio Preto, São Paulo, 15091-000, Brazil
Local Institution - 0223

Itacorubi, Florianopolis, Santa Catarina, 88034, Brazil
Local Institution - 0224

Budapest, 1122, Hungary
Local Institution - 0225

Hong Kong, 0, Hong Kong
Local Institution - 0226

Miami, Florida, 33136, United States
Local Institution - 0227

Shanghai, Shanghai Municipality, 200030, China
Local Institution - 0228

Tianjin, 300060, China
Local Institution - 0230

Hangzhou, Zhejiang, 310003, China
Local Institution - 0232

Shanghai, 200032, China
Local Institution - 0233

Linhai, Zhejiang, 317000, China
Local Institution - 0234

Fuzhou, Fujian, 350014, China
Local Institution - 0237

Brisbane, Queensland, 4102, Australia
Local Institution - 0238

Hangzhou, Zhejiang, 310022, China
Local Institution - 0239

Shanghai, Shanghai Municipality, 200032, China
Local Institution - 0240

Beijing, Beijing Municipality, 100142, China
Local Institution - 0241

Seattle, Washington, 98101, United States
Local Institution - 0243

Cardiff, CF14 2TL, United Kingdom
Local Institution - 0247

Denver, Colorado, 80218, United States
Local Institution - 0248

Dallas, Texas, 75246, United States
Local Institution - 0250

Tucson, Arizona, 85711, United States

Conditions

Explore the condition pages connected to this study.

ADVANCED CANCER