New combo therapy for rare bone cancer shows promise in early trial

NCT ID NCT01407198

First seen Jan 11, 2026 · Last updated May 29, 2026 · Updated 16 times

Summary

This early-phase study tested the safety of adding nilotinib, a drug that targets a specific growth signal in chordoma cells, to standard radiation therapy for people with high-risk chordoma. The goal was to find the highest safe dose of nilotinib when given with radiation. A total of 23 participants took part, and researchers monitored side effects to determine the best dose for future studies.

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Contacts and locations

Locations

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

Conditions

Explore the condition pages connected to this study.