Can a vitamin B3 pill help people with rare muscle disease?
NCT ID NCT05590468
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether nicotinamide riboside, a form of vitamin B3, can improve walking distance and muscle function in adults with mitochondrial myopathy, a rare muscle disorder. Thirty-four participants receive either the supplement or a placebo for several months. The main goal is to see if the supplement helps them walk farther in six minutes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
nicotinamide riboside (a form of vitamin B3)
What this could lead to
If it works, this could point toward a simple vitamin supplement to help manage mitochondrial myopathy symptoms.
What could go wrong
This is a small, early-phase trial with only 34 people. The supplement may not improve walking or muscle function, and results may not apply to everyone with the condition.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Mayo Clinic in Rochester
Rochester, Minnesota, 55905, United States