Radiation-Free hope: new combo tackles tough rectal cancer
NCT ID NCT06688786
First seen Jan 28, 2026 · Last updated May 12, 2026 · Updated 16 times
Summary
This study tests a new approach for people with locally advanced rectal cancer that has a specific genetic profile (MSS/pMMR). Instead of standard radiation, participants receive a combination of chemotherapy (mFOLFOX6) and an immunotherapy drug (PD-1 antibody) before surgery. The goal is to shrink the tumor, reduce side effects from radiation, and protect long-term bowel function. The trial includes 30 adults aged 18-75 with no prior cancer treatment.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, 200092, China
Conditions
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