New hope for transplant patients battling chronic immune rejection

NCT ID NCT06585774

Recruiting now Disease control Sponsor: Incyte Corporation Source: ClinicalTrials.gov ↗

Summary

This study is testing whether adding a new drug called axatilimab to standard steroid treatment works better than steroids alone for people with moderate to severe chronic graft-versus-host disease (cGVHD). cGVHD is a serious complication where the donor's immune cells attack the patient's body after a stem cell transplant. The trial will enroll 240 participants aged 12 and older who have recently been diagnosed and need their first systemic treatment.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

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Locations

Akh Und Medizinische Universitat Wien Universitatsklinik Fur Innere Medizin I
RECRUITING

Vienna, 01090, Austria
Alberta'S Children Hospital
RECRUITING

Calgary, Alberta, T3B 6A8, Canada
Amsterdam University Medical Centre
RECRUITING

Amsterdam, 1081 HV, Netherlands
Anjo Kosei Hospital
RECRUITING

Aichi, 446-8602, Japan
Asst Degli Spedali Civili Di Brescia
RECRUITING

Brescia, 25123, Italy
Austin Health Medical Oncology and Clinical Haematology
RECRUITING

Heidelberg, Victoria, 03084, Australia
Azienda Ospedaliera Card. G. Panico
RECRUITING

Tricase, 73039, Italy
Azienda Ospedaliera Di Rilievo Nazionale Antonio Cardarelli
RECRUITING

Naples, 80131, Italy
Azienda Ospedaliera Ospedali Riuniti Villa Sofia - Cervello
RECRUITING

Palermo, 90146, Italy
Azienda Ospedaliero Universitaria Delle Marche
RECRUITING

Ancona, 60126, Italy
Azienda Ospedaliero-Universitaria Di Alessandria Ss.Antonio E Biagio E Cesare Arrigo
RECRUITING

Alessandria, 15121, Italy
Azienda Policlinico Umberto 1 Universita Sapienza Di Roma
RECRUITING

Rome, 00161, Italy
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
RECRUITING

Milan, 20162, Italy
Baptist Cancer Center
RECRUITING

Memphis, Tennessee, 38120, United States
Bc Children'S Hospital
RECRUITING

Vancouver, British Columbia, V6G1R8, Canada
Bristol Haematology and Oncology Centre
RECRUITING

Bristol, BS2 8ED, United Kingdom
Centre Hospitalier Universitaire de Nantes (Chu de Nantes) - Hotel-Dieu
RECRUITING

Nantes, 44903, France
Centro Ricerche Cliniche Di Verona
RECRUITING

Verona, 37134, Italy
Charite Universitatsmedizin Berlin
RECRUITING

Berlin, 13353, Germany
Childrens National Hospital
RECRUITING

Washington D.C., District of Columbia, 20010, United States
Chu Amiens Picardie - Hopital Sud
RECRUITING

Amiens, 80054, France
Chu de Nice - Hospital L Archet
RECRUITING

Nice, 06202, France
Colorado Blood Cancer Institute
RECRUITING

Denver, Colorado, 80218, United States
Corewell Health Hematology Oncology
RECRUITING

Grand Rapids, Michigan, 49503, United States
Dana Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Emory University-Winship Cancer Institute
RECRUITING

Atlanta, Georgia, 30322, United States
Fujita Health University Hospital
RECRUITING

Aichi, 470-1192, Japan
Grande Ospedale Metropolitano Bianchi-Melacrino-Morelli
RECRUITING

Reggio Calabria, 89133, Italy
Gunma Saiseikai Maebashi Hospital
RECRUITING

Maebashi, 371-0821, Japan
Hackensack University Medical Center
RECRUITING

Hackensack, New Jersey, 07601, United States
Henry Ford Hospital
RECRUITING

Detroit, Michigan, 48202, United States
Hiroshima University Hospital
RECRUITING

Hiroshima, 734-8551, Japan
Hokkaido University Hospital
RECRUITING

Sapporo Hokkaido, 060-8648, Japan
Hopitaux de Brabois
RECRUITING

Nancy, 54511, France
Hospices Civils de Lyon Centre Hospitalier Lyon Sud
RECRUITING

Pierre-Bénite, 69310, France
Hospital General Universitario Gregorio Maranon
RECRUITING

Madrid, 28007, Spain
Hospital General Universitario Vall D Hebron
RECRUITING

Barcelona, 08035, Spain
Hospital Maisonneuve Rosemont
RECRUITING

Montreal, Quebec, H1T 2M4, Canada
Hospital Puerta de Hierro
RECRUITING

Majadahonda, 28222, Spain
Hospital Saint Antoine
RECRUITING

Paris, 75012, France
Hospital Saint Louis
RECRUITING

Paris, 75010, France
Hospital Universitari I Politecnic La Fe
RECRUITING

Valencia, 46026, Spain
Hospital Universitario Donostia
RECRUITING

Donostia / San Sebastian, 20014, Spain
Hospital Universitario Miguel Servet
RECRUITING

Zaragoza, 50009, Spain
Hospital Universitario Virgen Del Rocio
RECRUITING

Seville, 41013, Spain
Hospital Universitario de Gran Canaria Doctor Negrin
RECRUITING

Las Palmas de Gran Canaria, 35010, Spain
Hospital de La Santa Creu I Sant Pau
RECRUITING

Barcelona, 08041, Spain
I.R.C.C.S. Casa Sollievo Della Sofferenza
RECRUITING

San Giovanni Rotondo, 71013, Italy
Innsbruck University Hospital
RECRUITING

Innsbruck, A-6020, Austria
Institut Catala Doncologia Ico - Hospital Duran I Reynals Location
RECRUITING

L'Hospitalet de Llobregat, 08906, Spain
Intermountain Blood and Marrow Transplant
RECRUITING

Salt Lake City, Utah, 84143, United States
Irccs Azienda Ospedaliera Universitaria San Martino
RECRUITING

Genova, 16132, Italy
Irccs Fondazione Policlinico San Matteo
RECRUITING

Pavia, 27100, Italy
Jefferson University Hospitals
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
Juravinski Cancer Centre
RECRUITING

Hamilton, Ontario, L8V 5C2, Canada
Klinikum Der Philipps-Universitaet Marburg
RECRUITING

Marburg, 35043, Germany
Kobe City Medical Center General Hospital
RECRUITING

Hyōgo, 650-0047, Japan
Kyushu University Hospital
RECRUITING

Fukuoka, Japan
Landeskrankenhaus Universitatsklinikum Graz
RECRUITING

Graz, A-8036, Austria
Manchester University Nhs Foundation Trust
RECRUITING

Manchester, United Kingdom
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Medical University of South Carolina
RECRUITING

Charleston, South Carolina, 29425, United States
Memorial Cancer Institute
RECRUITING

Pembroke Pines, Florida, 33026, United States
Miami Cancer Institute
RECRUITING

Miami, Florida, 33176, United States
National Hospital Organization Kumamoto Medical Center
RECRUITING

Kumamoto, 860-0008, Japan
Nottingham University Hospitals
RECRUITING

Nottingham, NG5 1PB, United Kingdom
Okayama University Hospital
RECRUITING

Okayama Okayama, 700-0914, Japan
Ordensklinikum Linz Gmbh Elisabethinen
RECRUITING

LINZ CET, A-4020, Austria
Oregon Health and Science University
RECRUITING

Portland, Oregon, 97239, United States
Orlando Health Cancer Institute Downtown Orlando
RECRUITING

Orlando, Florida, 32806, United States
Osaka Metropolitan University Hospital
RECRUITING

Osaka, 545-8586, Japan
Ospedale Pediatrico Bambino Gesu Irccs
RECRUITING

Rome, 00165, Italy
Ospedale San Raffaele - Milano
RECRUITING

Milan, 20132, Italy
Plymouth Hospitals Nhs Trust
RECRUITING

Plymouth, PL6 8DH, United Kingdom
Princess Margaret Cancer Center
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
Prisma Health Upstate
RECRUITING

Greenville, South Carolina, 29615, United States
Queen Elizabeth Ii Health Sciences Centre
RECRUITING

Halifax, Nova Scotia, Canada
Queen Elizabeth University Hospital
RECRUITING

Glasgow, G51 4TF, United Kingdom
Rigshospitalet
RECRUITING

Copenhagen, 02100, Denmark
Royal Adelaide Hospital
RECRUITING

Adelaide, South Australia, 05000, Australia
Royal Marsden Hospital
RECRUITING

London, SM2 5PT, United Kingdom
Royal Prince Alfred Hospital
RECRUITING

Sydney, New South Wales, 02050, Australia
Rutgers Cancer Institute of Nj
RECRUITING

New Brunswick, New Jersey, 08903, United States
St David'S South Austin Medical Center
RECRUITING

Austin, Texas, 78704, United States
St. Anna Childrens Hospital
RECRUITING

Vienna, 01090, Austria
St. James Hospital
RECRUITING

Dublin, Ireland
Stony Brook University Medical Center
RECRUITING

Stony Brook, New York, 11794, United States
Texas Transplant Institute
RECRUITING

San Antonio, Texas, 78229, United States
The University of Kansas Cancer Center
RECRUITING

Kansas City, Kansas, 66160, United States
Tohoku University Hospital
RECRUITING

Miyagi, 980-8574, Japan
Tokai University Hospital
RECRUITING

Kanagawa, 259-1193, Japan
Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital
RECRUITING

Tokyo, 113-0021, Japan
Universitaetsklinikum Bonn, University Hospital Bonn
RECRUITING

Bonn, 53127, Germany
Universitaetsklinikum Erlangen
RECRUITING

Erlangen, 91054, Germany
Universitaire Du Cancer de Toulouse Institut Claudius Regaud Iuct-Oncopole
RECRUITING

Toulouse, 31059, France
Universitatsklinikum Essen
RECRUITING

Essen, 45147, Germany
Universitatsklinikum Halle (Saale)
RECRUITING

Halle, 06120, Germany
Universitatsklinikum Leipzig
RECRUITING

Leipzig, 04103, Germany
Universitatsklinikum Munster
RECRUITING

Münster, 48149, Germany
Universitatsmedizin Der Johannes Gutenberg-Universitat Mainz Iii
RECRUITING

Mainz, 55131, Germany
University Clinic Carl Gustav Carus Technical University Dresden
RECRUITING

Dresden, 01307, Germany
University College London Hospitals (Uclh)
RECRUITING

London, WC1E 6AG, United Kingdom
University Hospital Duesseldorf
RECRUITING

Düsseldorf, 40225, Germany
University Hospital Schleswig-Holstein Campus Kiel
RECRUITING

Kiel, 24105, Germany
University Medical Center Rwth Aachen
RECRUITING

Aachen, D-52074, Germany
University of Alabama Birmingham
RECRUITING

Birmingham, Alabama, 35294, United States
University of California San Diego Medical Center, Moores Cancer Center
RECRUITING

La Jolla, California, 92037, United States
University of Illinois
RECRUITING

Chicago, Illinois, 60612, United States
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Rochester Medical Center
RECRUITING

Rochester, New York, 14642, United States
University of Southern California
RECRUITING

Los Angeles, California, 90089, United States
Vancouver General Hospital
RECRUITING

Vancouver, V5Z1M9, Canada
Virginia Commonwealth University Massey Cancer Center
RECRUITING

Richmond, Virginia, 23298, United States
Wake Forest Baptist Medical Center
RECRUITING

Winston-Salem, North Carolina, 27157, United States
West Virginia University Cancer Institute
RECRUITING

Morgantown, West Virginia, 26506, United States

Conditions

Explore the condition pages connected to this study.

CHRONIC GRAFT VERSUS HOST DISEASE