Pfizer tests new hope for serious lung vessel disease

NCT ID NCT06137742

Ongoing Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

Summary

This early-stage study is testing a new drug, PF-07868489, to see if it is safe and how it works in the body. First, healthy volunteers receive a single dose. Then, people with pulmonary arterial hypertension (PAH), a serious condition of high blood pressure in the lungs, receive the drug for 24 weeks to see if it helps reduce strain on their heart and improves their ability to walk.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Anaheim Clinical Trials, LLC

Anaheim, California, 92801, United States
CHRU de Brest

Brest, Finistère, 29200, France
Center for Advanced Lung Care

Providence, Rhode Island, 02904, United States
Centre Hospitalier Universitaire de Saint Étienne - Hôpital Nord

Saint Priest En Jarez, Pays de la Loire Region, 42270, France
Chu Grenoble Alpes

La Tronche, 38700, France
Eastowne 100 Medical Office Building

Chapel Hill, North Carolina, 27514, United States
Eastowne Medical Office Building - Clinical Research Unit

Chapel Hill, North Carolina, 27514, United States
Fondazione IRCCS Policlinico San Matteo

Pavia, 27100, Italy
Fondazione IRCCS San Gerardo dei Tintori

Monza, Monza E Brianza, 20900, Italy
Gachon University Gil Medical Center

Namdong-gu, Incheon-gwangyeoksi [incheon], 21565, South Korea
Golden Jubilee National Hospital

Clydebank, G81 4DY, United Kingdom
Guangdong Provincial People's Hospital

Guangzhou, Guangdong, 510080, China
Hammersmith Hospital

London, London, CITY of, W12 0HS, United Kingdom
Hospital Universitario 12 de Octubre

Madrid, 28041, Spain
Hospital Universitario La Paz

Madrid, Madrid, Comunidad de, 28046, Spain
Hospital Universitario Marqués de Valdecilla

Santander, Cantabria, 39008, Spain
ISMETT Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione

Palermo, 90127, Italy
Icahn school of medicine at Mount Sinai

New York, New York, 10029, United States
Institut Klinicke a Experimentalni Mediciny

Prague, 140 21, Czechia
Investigational Drug Services Pharmacy

Morrisville, North Carolina, 27560, United States
Kobe University Hospital

Kobe, Hyōgo, 650-0017, Japan
London Health Sciences Centre - University Hospital

London, Ontario, N6G 2M3, Canada
London Health Sciences Centre - Verspeeten Family Cancer Centre

London, Ontario, N6A 5W9, Canada
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Medical University of South Carolina - Nexus

Charleston, South Carolina, 29425, United States
Medical University of South Carolina - Radiology

Charleston, South Carolina, 29425, United States
National Hospital Organization Okayama Medical Center

Okayama, 701-1154, Japan
Norton Hospital

Louisville, Kentucky, 40202, United States
Norton Pulmonary Specialists

Louisville, Kentucky, 40202, United States
Rhode Island Hospital

Providence, Rhode Island, 02903, United States
Royal Brompton Hospital

London, SW3 6NP, United Kingdom
Royal Free London NHS Foundation Trust, Royal Free Hospital

London, NW3 2QG, United Kingdom
Royal Prince Alfred Hospital

Camperdown, New South Wales, 2050, Australia
Samsung Medical Center

Seoul, Seoul-teukbyeolsi [seoul], 06351, South Korea
Seoul National University Hospital

Seoul, Seoul-teukbyeolsi [seoul], 03080, South Korea
Severance Hospital, Yonsei University Health System

Seoul, Seoul-teukbyeolsi [seoul], 03722, South Korea
Shanghai Pulmonary Hospital

Shanghai, Shanghai Municipality, 200433, China
St. Marianna University Hospital

Kawasaki, Kanagawa, 216-8511, Japan
The Second Xiangya Hospital of Central South University

Changsha, Hunan, 410011, China
Thoraxklinik-Heidelberg gGmbH

Heidelberg, Baden-Wurttemberg, 69126, Germany
Tohoku University Hospital

Sendai, Miyagi, 980-8574, Japan
UC Davis Health Medical Center

Sacramento, California, 95817, United States
UCI Health - Costa Mesa

Costa Mesa, California, 92627, United States
UCI Health Center for Innovative Health Therapies (CIHT)

Orange, California, 92868, United States
UCSF Health St. Mary's Hospital

San Francisco, California, 94117, United States
UCSF Helen Diller Medical Center at Parnassus Heights

San Francisco, California, 94143, United States
UKGM Gießen/Marburg

Giessen, Hesse, 35392, Germany
UNC Health - Eastowne Medical Office

Chapel Hill, North Carolina, 27514, United States
UNC Hospitals

Chapel Hill, North Carolina, 27514, United States
UZ Leuven

Leuven, Vlaams-brabant, 3000, Belgium
Universitaetsklinikum Carl Gustav Carus, Technischen Universitaet Dresden

Dresden, Saxony, 01307, Germany
University General Hospital "ATTIKON" - General Hospital of West Attica "H AGIA VARVARA"

Chaïdári, Attikí, 12462, Greece
University of California Davis Health

Sacramento, California, 95817, United States
University of California, Irvine Medical Center

Orange, California, 92868, United States
University of Colorado Anschutz Medical Campus

Aurora, Colorado, 80045, United States
Universitätsklinikum Regensburg

Regensburg, Bavaria, 93053, Germany
Universitätsmedizin Greifswald

Greifswald, Mecklenburg-Vorpommern, 17475, Germany
Université Libre de Bruxelles - Hôpital Erasme

Brussels, Bruxelles-capitale, Région de, 1070, Belgium
Vseobecna fakultni nemocnice v Praze

Prague, 12808, Czechia
Wesley Research Institute

Auchenflower, Queensland, 4066, Australia
Yokohama City University Hospital

Kanagawa, 236-0004, Japan
Zhongda Hospital Southeast University

Nanjing, Jiangsu, 210009, China

Conditions

Explore the condition pages connected to this study.

PULMONARY ARTERIAL HYPERTENSION