Major trial aims to boost survival for kids with tough cancer
NCT ID NCT06172296
Summary
This study is testing if adding a drug called dinutuximab to the first stage of treatment helps children with newly diagnosed high-risk neuroblastoma. Dinutuximab is an immunotherapy that helps the body's own immune system find and kill cancer cells. The trial will compare the current standard treatment to a new approach that includes this drug earlier, to see if it helps keep the cancer from coming back and helps children live longer.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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AdventHealth Orlando
RECRUITINGOrlando, Florida, 32803, United States
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Advocate Children's Hospital-Oak Lawn
RECRUITINGOak Lawn, Illinois, 60453, United States
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Advocate Children's Hospital-Park Ridge
RECRUITINGPark Ridge, Illinois, 60068, United States
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Albany Medical Center
RECRUITINGAlbany, New York, 12208, United States
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Alberta Children's Hospital
RECRUITINGCalgary, Alberta, T3B 6A8, Canada
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Alfred I duPont Hospital for Children
RECRUITINGWilmington, Delaware, 19803, United States
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Alliance for Childhood Diseases/Cure 4 the Kids Foundation
RECRUITINGLas Vegas, Nevada, 89135, United States
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Arkansas Children's Hospital
RECRUITINGLittle Rock, Arkansas, 72202-3591, United States
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Arnold Palmer Hospital for Children
RECRUITINGOrlando, Florida, 32806, United States
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BI-LO Charities Children's Cancer Center
RECRUITINGGreenville, South Carolina, 29605, United States
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Banner Children's at Desert
RECRUITINGMesa, Arizona, 85202, United States
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Banner University Medical Center - Tucson
RECRUITINGTucson, Arizona, 85719, United States
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Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
RECRUITINGHouston, Texas, 77030, United States
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Blank Children's Hospital
RECRUITINGDes Moines, Iowa, 50309, United States
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British Columbia Children's Hospital
RECRUITINGVancouver, British Columbia, V6H 3V4, Canada
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Bronson Methodist Hospital
RECRUITINGKalamazoo, Michigan, 49007, United States
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Broward Health Medical Center
RECRUITINGFort Lauderdale, Florida, 33316, United States
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C S Mott Children's Hospital
RECRUITINGAnn Arbor, Michigan, 48109, United States
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CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL)
RECRUITINGQuébec, G1V 4G2, Canada
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CancerCare Manitoba
RECRUITINGWinnipeg, Manitoba, R3E 0V9, Canada
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Carolinas Medical Center/Levine Cancer Institute
RECRUITINGCharlotte, North Carolina, 28203, United States
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Cedars Sinai Medical Center
RECRUITINGLos Angeles, California, 90048, United States
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Centre Hospitalier Universitaire Sainte-Justine
RECRUITINGMontreal, Quebec, H3T 1C5, Canada
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Centre Hospitalier Universitaire de Sherbrooke-Fleurimont
RECRUITINGSherbrooke, Quebec, J1H 5N4, Canada
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Children's Healthcare of Atlanta - Arthur M Blank Hospital
RECRUITINGAtlanta, Georgia, 30329, United States
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Children's Hospital
RECRUITINGLondon, Ontario, N6A 5W9, Canada
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Children's Hospital Colorado
RECRUITINGAurora, Colorado, 80045, United States
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Children's Hospital Los Angeles
RECRUITINGLos Angeles, California, 90027, United States
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Children's Hospital Medical Center of Akron
RECRUITINGAkron, Ohio, 44308, United States
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Children's Hospital New Orleans
RECRUITINGNew Orleans, Louisiana, 70118, United States
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Children's Hospital and Medical Center of Omaha
RECRUITINGOmaha, Nebraska, 68114, United States
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Children's Hospital of Alabama
RECRUITINGBirmingham, Alabama, 35233, United States
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Children's Hospital of Eastern Ontario
RECRUITINGOttawa, Ontario, K1H 8L1, Canada
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Children's Hospital of Michigan
RECRUITINGDetroit, Michigan, 48201, United States
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Children's Hospital of Orange County
RECRUITINGOrange, California, 92868, United States
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Children's Hospital of Philadelphia
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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Children's Hospital of Pittsburgh of UPMC
RECRUITINGPittsburgh, Pennsylvania, 15224, United States
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Children's Hospital of San Antonio
RECRUITINGSan Antonio, Texas, 78207, United States
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Children's Hospital of Wisconsin
RECRUITINGMilwaukee, Wisconsin, 53226, United States
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Children's Hospitals and Clinics of Minnesota - Minneapolis
RECRUITINGMinneapolis, Minnesota, 55404, United States
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Children's Mercy Hospitals and Clinics
RECRUITINGKansas City, Missouri, 64108, United States
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Children's National Medical Center
RECRUITINGWashington D.C., District of Columbia, 20010, United States
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Cincinnati Children's Hospital Medical Center
RECRUITINGCincinnati, Ohio, 45229, United States
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City of Hope Comprehensive Cancer Center
RECRUITINGDuarte, California, 91010, United States
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Cleveland Clinic Foundation
RECRUITINGCleveland, Ohio, 44195, United States
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Connecticut Children's Medical Center
RECRUITINGHartford, Connecticut, 06106, United States
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Cook Children's Medical Center
RECRUITINGFort Worth, Texas, 76104, United States
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Corewell Health Children's
RECRUITINGRoyal Oak, Michigan, 48073, United States
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Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
RECRUITINGGrand Rapids, Michigan, 49503, United States
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Covenant Children's Hospital
RECRUITINGLubbock, Texas, 79410, United States
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Dana-Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02215, United States
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Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
RECRUITINGLebanon, New Hampshire, 03756, United States
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Dayton Children's Hospital
RECRUITINGDayton, Ohio, 45404, United States
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Dell Children's Medical Center of Central Texas
RECRUITINGAustin, Texas, 78723, United States
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Driscoll Children's Hospital
RECRUITINGCorpus Christi, Texas, 78411, United States
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Duke University Medical Center
RECRUITINGDurham, North Carolina, 27710, United States
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East Carolina University
RECRUITINGGreenville, North Carolina, 27834, United States
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East Tennessee Childrens Hospital
RECRUITINGKnoxville, Tennessee, 37916, United States
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Eastern Maine Medical Center
RECRUITINGBangor, Maine, 04401, United States
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Edwards Comprehensive Cancer Center
RECRUITINGHuntington, West Virginia, 25701, United States
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El Paso Children's Hospital
RECRUITINGEl Paso, Texas, 79905, United States
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Geisinger Medical Center
RECRUITINGDanville, Pennsylvania, 17822, United States
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Golisano Children's Hospital of Southwest Florida
RECRUITINGFort Myers, Florida, 33908, United States
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Hackensack University Medical Center
RECRUITINGHackensack, New Jersey, 07601, United States
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Hospital for Sick Children
RECRUITINGToronto, Ontario, M5G 1X8, Canada
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IWK Health Centre
RECRUITINGHalifax, Nova Scotia, B3K 6R8, Canada
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Janeway Child Health Centre
RECRUITINGSt. John's, Newfoundland and Labrador, A1B 3V6, Canada
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Jim Pattison Children's Hospital
RECRUITINGSaskatoon, Saskatchewan, S7N 0W8, Canada
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Johns Hopkins All Children's Hospital
RECRUITINGSt. Petersburg, Florida, 33701, United States
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Johns Hopkins University/Sidney Kimmel Cancer Center
RECRUITINGBaltimore, Maryland, 21287, United States
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Kaiser Permanente Downey Medical Center
RECRUITINGDowney, California, 90242, United States
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Kaiser Permanente-Oakland
RECRUITINGOakland, California, 94611, United States
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Kapiolani Medical Center for Women and Children
RECRUITINGHonolulu, Hawaii, 96826, United States
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Laura and Isaac Perlmutter Cancer Center at NYU Langone
RECRUITINGNew York, New York, 10016, United States
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Legacy Emanuel Children's Hospital
RECRUITINGPortland, Oregon, 97227, United States
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Lehigh Valley Hospital-Cedar Crest
RECRUITINGAllentown, Pennsylvania, 18103, United States
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Loma Linda University Medical Center
RECRUITINGLoma Linda, California, 92354, United States
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Lucile Packard Children's Hospital Stanford University
RECRUITINGPalo Alto, California, 94304, United States
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Lurie Children's Hospital-Chicago
RECRUITINGChicago, Illinois, 60611, United States
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M D Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
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Maine Children's Cancer Program
RECRUITINGScarborough, Maine, 04074, United States
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Marshfield Medical Center-Marshfield
RECRUITINGMarshfield, Wisconsin, 54449, United States
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Mary Bridge Children's Hospital and Health Center
RECRUITINGTacoma, Washington, 98405, United States
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Massachusetts General Hospital Cancer Center
RECRUITINGBoston, Massachusetts, 02114, United States
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Mattel Children's Hospital UCLA
RECRUITINGLos Angeles, California, 90095, United States
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Mayo Clinic in Rochester
RECRUITINGRochester, Minnesota, 55905, United States
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McMaster Children's Hospital at Hamilton Health Sciences
RECRUITINGHamilton, Ontario, L8N 3Z5, Canada
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Medical City Dallas Hospital
RECRUITINGDallas, Texas, 75230, United States
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Medical University of South Carolina
RECRUITINGCharleston, South Carolina, 29425, United States
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Memorial Regional Hospital/Joe DiMaggio Children's Hospital
RECRUITINGHollywood, Florida, 33021, United States
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Mercy Hospital Saint Louis
RECRUITINGSt Louis, Missouri, 63141, United States
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Methodist Children's Hospital of South Texas
RECRUITINGSan Antonio, Texas, 78229, United States
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Miller Children's and Women's Hospital Long Beach
RECRUITINGLong Beach, California, 90806, United States
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Mission Hospital
RECRUITINGAsheville, North Carolina, 28801, United States
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Montefiore Medical Center - Moses Campus
RECRUITINGThe Bronx, New York, 10467, United States
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Morristown Medical Center
RECRUITINGMorristown, New Jersey, 07960, United States
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NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
RECRUITINGNew York, New York, 10032, United States
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NYU Langone Hospital - Long Island
RECRUITINGMineola, New York, 11501, United States
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Natalie Warren Bryant Cancer Center at Saint Francis
RECRUITINGTulsa, Oklahoma, 74136, United States
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Nationwide Children's Hospital
RECRUITINGColumbus, Ohio, 43205, United States
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Naval Medical Center - Portsmouth
RECRUITINGPortsmouth, Virginia, 23708-2197, United States
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Nemours Children's Clinic-Jacksonville
RECRUITINGJacksonville, Florida, 32207, United States
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Nemours Children's Hospital
RECRUITINGOrlando, Florida, 32827, United States
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New York Medical College
RECRUITINGValhalla, New York, 10595, United States
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Nicklaus Children's Hospital
RECRUITINGMiami, Florida, 33155, United States
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Norton Children's Hospital
RECRUITINGLouisville, Kentucky, 40202, United States
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Novant Health Presbyterian Medical Center
RECRUITINGCharlotte, North Carolina, 28204, United States
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Oregon Health and Science University
RECRUITINGPortland, Oregon, 97239, United States
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Perth Children's Hospital
RECRUITINGPerth, Western Australia, 6009, Australia
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Phoenix Childrens Hospital
RECRUITINGPhoenix, Arizona, 85016, United States
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Primary Children's Hospital
RECRUITINGSalt Lake City, Utah, 84113, United States
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Prisma Health Richland Hospital
RECRUITINGColumbia, South Carolina, 29203, United States
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ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
RECRUITINGToledo, Ohio, 43606, United States
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Providence Sacred Heart Medical Center and Children's Hospital
RECRUITINGSpokane, Washington, 99204, United States
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Queensland Children's Hospital
RECRUITINGSouth Brisbane, Queensland, 4101, Australia
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Rady Children's Hospital - San Diego
RECRUITINGSan Diego, California, 92123, United States
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Rainbow Babies and Childrens Hospital
RECRUITINGCleveland, Ohio, 44106, United States
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Rhode Island Hospital
RECRUITINGProvidence, Rhode Island, 02903, United States
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Riley Hospital for Children
RECRUITINGIndianapolis, Indiana, 46202, United States
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Roswell Park Cancer Institute
RECRUITINGBuffalo, New York, 14263, United States
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Royal Children's Hospital
RECRUITINGParkville, Victoria, 3052, Australia
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Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital
RECRUITINGNew Brunswick, New Jersey, 08903, United States
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Saint Christopher's Hospital for Children
RECRUITINGPhiladelphia, Pennsylvania, 19134, United States
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Saint Joseph's Regional Medical Center
RECRUITINGPaterson, New Jersey, 07503, United States
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Saint Jude Children's Research Hospital
RECRUITINGMemphis, Tennessee, 38105, United States
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Saint Jude Midwest Affiliate
RECRUITINGPeoria, Illinois, 61637, United States
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Saint Mary's Medical Center
RECRUITINGWest Palm Beach, Florida, 33407, United States
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Saint Peter's University Hospital
RECRUITINGNew Brunswick, New Jersey, 08901, United States
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Saint Vincent Hospital Cancer Center Green Bay
SUSPENDEDGreen Bay, Wisconsin, 54301, United States
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Sanford Broadway Medical Center
RECRUITINGFargo, North Dakota, 58122, United States
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Sanford USD Medical Center - Sioux Falls
RECRUITINGSioux Falls, South Dakota, 57117-5134, United States
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Seattle Children's Hospital
RECRUITINGSeattle, Washington, 98105, United States
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Sinai Hospital of Baltimore
RECRUITINGBaltimore, Maryland, 21215, United States
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Southern Illinois University School of Medicine
RECRUITINGSpringfield, Illinois, 62702, United States
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Starship Children's Hospital
RECRUITINGGrafton, Auckland, 1145, New Zealand
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State University of New York Upstate Medical University
RECRUITINGSyracuse, New York, 13210, United States
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Sutter Medical Center Sacramento
RECRUITINGSacramento, California, 95816, United States
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Sydney Children's Hospital
RECRUITINGRandwick, New South Wales, 2031, Australia
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The Children's Hospital at TriStar Centennial
RECRUITINGNashville, Tennessee, 37203, United States
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The Children's Hospital at Westmead
RECRUITINGWestmead, New South Wales, 2145, Australia
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The Montreal Children's Hospital of the MUHC
RECRUITINGMontreal, Quebec, H3H 1P3, Canada
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The Steven and Alexandra Cohen Children's Medical Center of New York
RECRUITINGNew Hyde Park, New York, 11040, United States
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UCSF Benioff Children's Hospital Oakland
RECRUITINGOakland, California, 94609, United States
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UCSF Medical Center-Mission Bay
RECRUITINGSan Francisco, California, 94158, United States
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UF Health Cancer Institute - Gainesville
RECRUITINGGainesville, Florida, 32610, United States
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UMC Cancer Center / UMC Health System
RECRUITINGLubbock, Texas, 79415, United States
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UNC Lineberger Comprehensive Cancer Center
RECRUITINGChapel Hill, North Carolina, 27599, United States
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USA Health Strada Patient Care Center
RECRUITINGMobile, Alabama, 36604, United States
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UT Southwestern/Simmons Cancer Center-Dallas
RECRUITINGDallas, Texas, 75390, United States
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University of Alberta Hospital
RECRUITINGEdmonton, Alberta, T6G 2B7, Canada
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University of California Davis Comprehensive Cancer Center
RECRUITINGSacramento, California, 95817, United States
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University of Chicago Comprehensive Cancer Center
RECRUITINGChicago, Illinois, 60637, United States
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University of Illinois
RECRUITINGChicago, Illinois, 60612, United States
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University of Iowa/Holden Comprehensive Cancer Center
RECRUITINGIowa City, Iowa, 52242, United States
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University of Kentucky/Markey Cancer Center
RECRUITINGLexington, Kentucky, 40536, United States
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University of Maryland/Greenebaum Cancer Center
RECRUITINGBaltimore, Maryland, 21201, United States
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University of Miami Miller School of Medicine-Sylvester Cancer Center
RECRUITINGMiami, Florida, 33136, United States
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University of Minnesota/Masonic Cancer Center
RECRUITINGMinneapolis, Minnesota, 55455, United States
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University of Mississippi Medical Center
RECRUITINGJackson, Mississippi, 39216, United States
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University of Missouri Children's Hospital
RECRUITINGColumbia, Missouri, 65212, United States
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University of Nebraska Medical Center
RECRUITINGOmaha, Nebraska, 68198, United States
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University of New Mexico Cancer Center
RECRUITINGAlbuquerque, New Mexico, 87106, United States
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University of Oklahoma Health Sciences Center
RECRUITINGOklahoma City, Oklahoma, 73104, United States
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University of Rochester
RECRUITINGRochester, New York, 14642, United States
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University of Texas Health Science Center at San Antonio
RECRUITINGSan Antonio, Texas, 78229, United States
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University of Vermont and State Agricultural College
RECRUITINGBurlington, Vermont, 05405, United States
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University of Virginia Cancer Center
RECRUITINGCharlottesville, Virginia, 22908, United States
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University of Wisconsin Carbone Cancer Center - University Hospital
RECRUITINGMadison, Wisconsin, 53792, United States
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Valley Children's Hospital
RECRUITINGMadera, California, 93636, United States
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Vanderbilt University/Ingram Cancer Center
RECRUITINGNashville, Tennessee, 37232, United States
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Wake Forest University Health Sciences
RECRUITINGWinston-Salem, North Carolina, 27157, United States
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Walter Reed National Military Medical Center
RECRUITINGBethesda, Maryland, 20889-5600, United States
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Washington University School of Medicine
RECRUITINGSt Louis, Missouri, 63110, United States
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Wesley Medical Center
RECRUITINGWichita, Kansas, 67214, United States
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Yale University
RECRUITINGNew Haven, Connecticut, 06520, United States
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Conditions
Explore the condition pages connected to this study.