Quadruple drug attack tested against triple therapy in blood cancer battle

NCT ID NCT03652064

Summary

This study is testing whether adding a fourth drug called daratumumab to a standard three-drug combination works better for people newly diagnosed with multiple myeloma who aren't planning an immediate stem cell transplant. Researchers want to see if the four-drug combination helps more patients achieve 'minimal residual disease negativity' - meaning extremely low levels of cancer cells that can't be detected by sensitive tests. The trial involves 395 participants and will compare the four-drug regimen against the standard three-drug treatment over approximately 6.5 years.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Albert Schweitzer ziekenhuis-lokatie Dordwijk

    Dordrecht, 3318 AT, Netherlands

  • Altnagelvin Hospital

    Londonderry, BT47 6SB, United Kingdom

  • Ankara University School of Medicine Cebeci Hospital

    Ankara, 06590, Turkey (Türkiye)

  • Arthur J E Child Comprehensive Cancer Centre

    Calgary, Alberta, T2N 5G2, Canada

  • Baptist MD Anderson

    Jacksonville, Florida, 32207, United States

  • Barzilai Medical Center

    Ashkelon, 78741, Israel

  • Blackpool Victoria Hospital

    Blackpool, FY3 8NR, United Kingdom

  • Boston University Medical Center

    Boston, Massachusetts, 02118, United States

  • Brampton Civic Hospital

    Brampton, Ontario, L6R 3J7, Canada

  • CHU Henri Mondor

    Créteil, 94010, France

  • CHU de Bordeaux - Hospital Haut-Leveque

    Pessac, 33604, France

  • CHU de Montpellier Hopital Saint Eloi

    Montpellier, 34295, France

  • CHU de Quebec L Hotel Dieu de Quebec

    Québec, Quebec, G1J 1Z4, Canada

  • Cancer And Hematology Centers of Western Michigan PC

    Grand Rapids, Michigan, 49503, United States

  • Carmel Medical Center

    Haifa, 3436212, Israel

  • Centre Hospitalier Départmental La Roche sur Yon

    La Roche-sur-Yon, 85925, France

  • Centrum Onkologii Ziemi Lubelskiej im sw Jana z Dukli

    Lublin, 20090, Poland

  • Cleveland Clinic

    Cleveland, Ohio, 44195, United States

  • Clinica Medica Sao Germano S/S LTDA

    São Paulo, 04537-081, Brazil

  • Colchester Hospital University NHS

    Colchester, CO4 5JL, United Kingdom

  • Cross Cancer Institute

    Edmonton, Alberta, T6G 1Z2, Canada

  • Derriford Hospital

    Plymouth, PL6 8DH, United Kingdom

  • Dokuz Eylul University Medical Faculty

    Izmir, 35340, Turkey (Türkiye)

  • Dr Abdurrahman Yurtaslan Oncology Training and Research Hospital

    Ankara, 06200, Turkey (Türkiye)

  • Erasmus MC

    Rotterdam, 3015CE, Netherlands

  • Fakultni Nemocnice Ostrava

    Ostrava, 708 52, Czechia

  • Fakultni nemocnice Brno

    Brno, 625 00, Czechia

  • Fakultni nemocnice Hradec Kralove

    Hradec Králové, 500 05, Czechia

  • Fakultni nemocnice Plzen, Hemato-onkologicke oddeleni

    Pilsen, 323 00, Czechia

  • Fort Wayne Medical Oncology and Hematology, Inc.

    Fort Wayne, Indiana, 46804, United States

  • Fukuoka University Hospital

    Fukuoka, 814-0180, Japan

  • Gibbs Cancer Center

    Spartanburg, South Carolina, 29303, United States

  • Good Samaritan Hospital Corvallis

    Corvallis, Oregon, 97330, United States

  • Gulhane Egitim ve Arastirma Hastanesi

    Ankara, 06010, Turkey (Türkiye)

  • Hacettepe University Medical Faculty

    Ankara, 06100, Turkey (Türkiye)

  • Hillel Yaffe Medical Center

    Hadera, 38100, Israel

  • Hopital Claude Huriez

    Lille, 59037, France

  • Hosp. Del Mar

    Barcelona, 08003, Spain

  • Hosp. Mutua Terrassa

    Terrassa, 08221, Spain

  • Hosp. Quiron Madrid Pozuelo

    Pozuelo de Alarcón, 28223, Spain

  • Hosp. Univ. Fundacion Alcorcon

    Alcorcón, 28922, Spain

  • Hosp. Univ. Pta. de Hierro Majadahonda

    Majadahonda, 28222, Spain

  • Hosp. Univ. de Guadalajara

    Guadalajara, 19002, Spain

  • Hospital Santa Cruz

    São Paulo, 04122-000, Brazil

  • Innovative Clinical Research Inc

    Cerritos, California, 90703, United States

  • Institut Paoli Calmettes

    Marseille, 13009, France

  • Institut Universitaire du cancer de Toulouse-Oncopole

    Toulouse, 31059, France

  • Institut für Versorgungsforschung

    Koblenz, 56068, Germany

  • Instituto Brasileiro de Controle do Cancer - Sao Camilo Oncologia

    São Paulo, 03102-002, Brazil

  • Instituto de Educacao, Pesquisa e Gestao em Saude Instituto Americas (COI)

    Rio de Janeiro, 22775 001, Brazil

  • Instituto de Ensino e Pesquisa São Lucas

    São Paulo, 01227-200, Brazil

  • Instytut Hematologii i Transfuzjologii

    Warsaw, 02 776, Poland

  • Istanbul University Istanbul Medical Faculty

    Istanbul, 34093, Turkey (Türkiye)

  • Japanese Red Cross Medical Center

    Shibuya City, 150-8935, Japan

  • Japanese Red Cross Osaka Hospital

    Osaka, 543 8555, Japan

  • Kanazawa University Hospital

    Kanazawa, 920 8641, Japan

  • Klinikum Großhadern der Ludwig-Maximilians-Universität

    München, 81377, Germany

  • Kobe City Medical Center General Hospital

    Kobe, 650 0047, Japan

  • Lakeridge Health Oshawa

    Oshawa, Ontario, L1G-2B9, Canada

  • Leicester Royal Infirmary - Haematology

    Leicester, LE1 5WW, United Kingdom

  • Levine Cancer Institute

    Charlotte, North Carolina, 28204, United States

  • Liga Norte Riograndense Contra O Cancer

    Natal, 59062 000, Brazil

  • Matsuyama Red Cross Hospital

    Matsuyama, 790-8524, Japan

  • McGill University Health Centre

    Montreal, Quebec, H4A 3J1, Canada

  • Meir Hospital

    Kfar Saba, 44281, Israel

  • Ministerio da Saude Instituto Nacional do Cancer

    Rio de Janeiro, 20230-130, Brazil

  • Monklands District General Hospital

    Airdrie, ML6 0JS, United Kingdom

  • NSSU Szpital Uniwersytecki w Krakowie

    Krakow, 30 688, Poland

  • NYU Winthrop

    Mineola, New York, 11501, United States

  • Nagoya City University Hospital

    Nagoya, 467 8602, Japan

  • Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut Badawczy

    Warsaw, 02-781, Poland

  • National Hospital Organization Kumamoto Medical Center

    Kumamoto, 860-0008, Japan

  • National Hospital Organization Matsumoto Medical Center

    Matsumoto, 399-8701, Japan

  • National Hospital Organization Okayama Medical Center

    Okayama, 701-1192, Japan

  • National Hospital Organization Shibukawa Medical Center

    Shibukawa, 377-0280, Japan

  • New Cross Hospital

    Wolverhampton, WV10 0QP, United Kingdom

  • Norton Healthcare

    Louisville, Kentucky, 40207, United States

  • Ogaki Municipal Hospital

    Gifu, 503-8502, Japan

  • Ondokuz Mayis University

    Samsun, 55280, Turkey (Türkiye)

  • QEII Health Sciences Centre

    Halifax, Nova Scotia, B3H 1V7, Canada

  • Rabin Medical Center

    Petah Tikva, 49100, Israel

  • Rambam Med.Center - Hematology Institute

    Haifa, 3109601, Israel

  • Real e Benemerita Associacao Portuguesa de Beneficencia

    São Paulo, 01323 900, Brazil

  • Roswell Park Cancer Institute

    Buffalo, New York, 14263, United States

  • Rutgers Cancer Institute of New Jersey

    New Brunswick, New Jersey, 08901, United States

  • Saint Lukes Hospital Saint Lukes Cancer Specialists

    Kansas City, Missouri, 64111, United States

  • Samodzielny Publiczny Zaklad Opieki Zdrowotnej Zespol Szpitali Miejskich

    Chorzów, 41-500, Poland

  • San Juan Oncology Associates

    Farmington, New Mexico, 87401, United States

  • Sheba Medical Center

    Ramat Gan, 52621, Israel

  • Sourasky (Ichilov) Medical Center

    Tel Aviv, 64239, Israel

  • St. Josef-Krankenhaus Hamm-Bockum-Hövel

    Hamm, 59075, Germany

  • Strasbourg Oncologie Libérale

    Strasbourg, 67000, France

  • Swietokrzyskie Centrum Onkologii SPZOZ w Kielcach

    Kielce, 25 734, Poland

  • Szpital Specjalistyczny w Brzozowie Podkarpacki Osrodek Onkologiczny im Ks B Markiewicza

    Brzozów, 36-200, Poland

  • The Gordon & Leslie Diamond Health Care Center

    Vancouver, British Columbia, V5Z 1M9, Canada

  • The Royal Oldham Hospital

    Oldham, OL1 2JH, United Kingdom

  • Tufts Medical Center

    Boston, Massachusetts, 02111, United States

  • Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da PUCRS

    Porto Alegre, 90610-000, Brazil

  • Universidade Estadual De Campinas

    Campinas, 13083-878, Brazil

  • Universitaetsklinikum Tuebingen der Eberhard-Karls-Universitaet, Abteilung fuer Innere Medizin II,

    Tübingen, 72076, Germany

  • Universitatsklinikum Freiburg

    Freiburg im Breisgau, 79106, Germany

  • Universitatsmedizin Leipzig

    Leipzig, 4103, Germany

  • University Hospital Kyoto Prefectural University of Medicine

    Kyoto, 602-8566, Japan

  • University Hospital Wales

    Cardiff, CF14 4XN, United Kingdom

  • University Of Pittsburgh Medical Center UPMC Hillman Cancer Center

    Pittsburgh, Pennsylvania, 15232 1301, United States

  • University of Texas, MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • University of Virginia

    Charlottesville, Virginia, 22908, United States

  • Uniwersytecki Szpital Kliniczny w Poznaniu

    Poznan, 60-569, Poland

  • Uniwersyteckie Centrum Kliniczne

    Gdansk, 80 214, Poland

  • VU Medisch Centrum

    Amsterdam, 1081 HV, Netherlands

  • Victoria Hospital

    London, Ontario, N6A 5W9, Canada

  • Vseobecna fakultni nemocnice v Praze

    Prague, 128 08, Czechia

  • Wojewodzki Szpital Specjalistyczny im. Janusza Korczaka

    Słupsk, 76-200, Poland

  • phase 3 - Hämatoonkologischer Studienkreis am Klinikum Aschaffenburg

    Aschaffenburg, 63739, Germany

Conditions

Explore the condition pages connected to this study.