Promising new combo therapy aims for Long-Term control in multiple myeloma

NCT ID NCT06577025

First seen Oct 31, 2025 · Last updated May 03, 2026 · Updated 30 times

Summary

This study tests different sequences of advanced cell and antibody therapies (Cilta-cel, Tal-D, Tec-D) after initial chemotherapy in 43 people with newly diagnosed multiple myeloma. The goal is to see if these combinations can achieve deep, lasting remission with no detectable cancer cells for at least 2 years and clear scans at 5 years. While the study uses the term 'curative potential,' participants may still need ongoing monitoring or future treatment, so this is best described as aiming for long-term disease control.

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Contacts and locations

Locations

  • City of Hope

    Duarte, California, 91010, United States

  • Fundacao Antonio Prudente A C Camargo Cancer Center

    São Paulo, 01509 900, Brazil

  • Hosp Clinico Univ de Salamanca

    Salamanca, 37007, Spain

  • Hosp. Univ. 12 de Octubre

    Madrid, 28041, Spain

  • Hosp. Univ. Marques de Valdecilla

    Santander, 39008, Spain

  • Instituto D Or de Pesquisa e Ensino

    Salvador, 41253 190, Brazil

  • Levine Cancer Institute

    Charlotte, North Carolina, 28204, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Peter MacCallum Cancer Centre

    Melbourne, 3000, Australia

  • Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein

    São Paulo, 05652 900, Brazil

  • The Alfred Hospital

    Melbourne, 3004, Australia

  • Universitaetsklinikum Heidelberg

    Heidelberg, 69120, Germany

  • Universitaetsklinikum Tuebingen

    Tübingen, 72076, Germany

  • Universitatsklinikum Wurzburg

    Würzburg, 97080, Germany

  • University of California San Francisco

    San Francisco, California, 94143, United States

  • University of Iowa Hospital and Clinics

    Iowa City, Iowa, 52242, United States

Conditions

Explore the condition pages connected to this study.