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Could a drug combo replace chemo and transplant for multiple myeloma?

NCT ID NCT06918002

Recruiting now Disease control Sponsor: Intergroupe Francophone du Myelome Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 12, 2026 · Updated 2 times

Summary

This study tests whether a combination of two drugs (elranatamab and lenalidomide) can replace high-dose chemotherapy and stem cell transplant for people newly diagnosed with multiple myeloma. About 824 adults under 70 will be randomly assigned to either standard treatment or the experimental drug combo. After initial therapy, participants will be re-randomized to receive either standard maintenance or elranatamab alone to see which better prevents the cancer from returning.

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Conditions

The condition(s) this trial relates to.

plasma cell myeloma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE MYELOMA, NEWLY DIAGNOSED

Contacts and locations

Locations

  • CH Bretagne Atlantique Vannes et Auray - P. Chubert

    RECRUITING

    Vannes, France

  • CH Fleyriat

    RECRUITING

    Bourg-en-Bresse, France

  • CH Le mans

    RECRUITING

    Le Mans, France

  • CH Saint Jean

    RECRUITING

    Perpignan, France

  • CHD Vendée

    RECRUITING

    La Roche-sur-Yon, France

  • CHMS Centre Hospitalier Métropole Savoie

    RECRUITING

    Chambéry, France

  • CHR Orléans

    RECRUITING

    Orléans, France

  • CHRU Brest - Hôpital A. Morvan

    RECRUITING

    Brest, France

  • CHRU Hôpital Bretonneau - Centre Henry Kaplan

    RECRUITING

    Tours, France

  • CHRU Hôpital Claude Huriez

    RECRUITING

    Lille, France

  • CHRU Hôpital de Pontchaillou

    RECRUITING

    Rennes, France

  • CHRU Hôpitaux de Brabois

    RECRUITING

    Nancy, France

  • CHRU Hôtel Dieu

    RECRUITING

    Nantes, France

  • CHU Amiens

    RECRUITING

    Amiens, France

  • CHU Angers

    RECRUITING

    Angers, France

  • CHU Besançon

    RECRUITING

    Besançon, France

  • CHU Bordeaux - Hopital Haut Lévêque - Centre F. Magendi

    RECRUITING

    Bordeaux, France

  • CHU Caen - Côte de Nacre

    RECRUITING

    Caen, France

  • CHU Carémeau, Institut de Cancérologie du Guard

    NOT_YET_RECRUITING

    Nîmes, France

  • CHU Dijon

    RECRUITING

    Dijon, France

  • CHU Henri Mondor

    RECRUITING

    Créteil, France

  • CHU Hôpital Saint Antoine

    RECRUITING

    Paris, France

  • CHU Poitiers - Pôle régional de Cancérologie

    RECRUITING

    Poitiers, France

  • CHU Strasbourg

    NOT_YET_RECRUITING

    Strasbourg, France

  • CHU de Grenoble

    RECRUITING

    Grenoble, France

  • CHU de la Réunion Site SUD (Terre Sainte)

    RECRUITING

    La Réunion, France

  • CHV André Mignot - Université de Versailles

    RECRUITING

    Versailles, France

  • Centre Henri Becquerel

    RECRUITING

    Rouen, France

  • Centre Hospitalier H. Duffaut

    RECRUITING

    Avignon, France

  • Centre Hospitalier Lyon Sud

    RECRUITING

    Lyon, France

  • Centre Hospitalier Saint Brieuc

    RECRUITING

    Saint-Brieuc, France

  • Centre Hospitalier Simone Veil

    RECRUITING

    Blois, France

  • Centre Hospitalier Sud Francilien

    RECRUITING

    Corbeil-Essonnes, France

  • Centre Hospitalier Universitaire (CHU) de Limoges

    RECRUITING

    Limoges, France

  • Centre Hospitalier William Morey

    RECRUITING

    Chalon-sur-Saône, France

  • Centre Hospitalier d'Argenteuil Victor Dupouy

    RECRUITING

    Argenteuil, France

  • Centre Hospitalier de Dunkerque

    RECRUITING

    Dunkirk, France

  • Centre Hospitalier de Perigueux

    RECRUITING

    Périgueux, France

  • Centre Hospitalier de Quimper Cornouaille

    RECRUITING

    Quimper, France

  • Centre Hospitalier de Saint-Quentin

    RECRUITING

    Saint-Quentin, France

  • Centre Léon Bérard

    NOT_YET_RECRUITING

    Lyon, 69373, France

  • Centre de Recherche Clinique / GHT des Landes

    RECRUITING

    Mont-de-Marsan, France

  • Centre hospitalier

    RECRUITING

    Tarbes, France

  • Centre hospitalier René Dubost

    RECRUITING

    Pontoise, France

  • Centre hospitalier de la Côte Basque

    RECRUITING

    Bayonne, France

  • Ch Annecy Genevois

    RECRUITING

    Annecy, France

  • Chu Estaing

    RECRUITING

    Clermont-Ferrand, France

  • Grand Hopital Est Francilien (GHEF) Site de Meaux

    RECRUITING

    Meaux, France

  • Gustave Roussy

    RECRUITING

    Villejuif, France

  • Hopital Louis Pasteur

    RECRUITING

    Chartres, France

  • Hopital Monod

    RECRUITING

    Le Havre, France

  • Hopital Saint Eloi - CHU Montpellier

    RECRUITING

    Montpellier, France

  • Hôpital Archet 1

    RECRUITING

    Nice, France

  • Hôpital Avicenne

    RECRUITING

    Bobigny, France

  • Hôpital Cochin

    RECRUITING

    Paris, France

  • Hôpital E. Muller

    RECRUITING

    Mulhouse, France

  • Hôpital Necker

    RECRUITING

    Paris, France

  • Hôpital Saint Louis

    RECRUITING

    Paris, France

  • Hôpital d'Instruction des Armées Percy

    RECRUITING

    Clamart, France

  • Hôpital de Mercy (CHR Metz-Thionville)

    RECRUITING

    Metz, France

  • Institut de Cancérologie Lucien Neuwirth

    RECRUITING

    Saint-Priest, France

  • Institut de cancérologie de Bourgogne

    RECRUITING

    Dijon, France

  • La Pitié Salpêtrière

    RECRUITING

    Paris, France

  • Pôle IUCT Oncopole CHU

    RECRUITING

    Toulouse, France

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