Global race for better mesothelioma treatment: new drug combo enters final testing phase

NCT ID NCT06097728

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Sep 30, 2025 · Last updated Apr 15, 2026 · Updated 22 times

Summary

This study is testing whether adding an experimental drug called volrustomig to standard chemotherapy works better than current treatments for advanced pleural mesothelioma that cannot be removed by surgery. About 825 adults with this aggressive cancer will receive either the new combination or one of two standard treatment options. The main goal is to see if the new approach helps people live longer while monitoring side effects and quality of life.

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Contacts and locations

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Study contacts

Contact

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Locations

Research Site
RECRUITING

Columbus, Ohio, 43210, United States
Research Site
WITHDRAWN

Independence, Ohio, 44131, United States
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RECRUITING

Portland, Oregon, 97213, United States
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RECRUITING

Portland, Oregon, 97225, United States
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WITHDRAWN

Portland, Oregon, 97239, United States
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Philadelphia, Pennsylvania, 19104, United States
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RECRUITING

Houston, Texas, 77030, United States
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RECRUITING

Fairfax, Virginia, 22031, United States
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ACTIVE_NOT_RECRUITING

Chermside, 4032, Australia
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Clayton, 3168, Australia
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Melbourne, 3000, Australia
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Nedlands, 6009, Australia
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Westmead, 2145, Australia
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ACTIVE_NOT_RECRUITING

Anderlecht, 1070, Belgium
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ACTIVE_NOT_RECRUITING

Antwerp, 2020, Belgium
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COMPLETED

Ghent, 9000, Belgium
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ACTIVE_NOT_RECRUITING

Hasselt, 3500, Belgium
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WITHDRAWN

Leuven, 3000, Belgium
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ACTIVE_NOT_RECRUITING

Sint-Niklaas, 9100, Belgium
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ACTIVE_NOT_RECRUITING

Barretos, 14784-400, Brazil
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Fortaleza, 60336-045, Brazil
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WITHDRAWN

João Pessoa, 58013-140, Brazil
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ACTIVE_NOT_RECRUITING

Porto Alegre, 91350-200, Brazil
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ACTIVE_NOT_RECRUITING

Rio de Janeiro, 22281-100, Brazil
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ACTIVE_NOT_RECRUITING

Santo André, 09060-650, Brazil
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São Paulo, 01246-000, Brazil
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ACTIVE_NOT_RECRUITING

Edmonton, Alberta, T6G 1Z2, Canada
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WITHDRAWN

Hamilton, Ontario, L8V 1C3, Canada
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RECRUITING

London, Ontario, N6A 5W9, Canada
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ACTIVE_NOT_RECRUITING

Ottawa, Ontario, K1H 8L6, Canada
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Toronto, Ontario, M5G 1X6, Canada
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Montreal, Quebec, H2X 0C1, Canada
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Québec, Quebec, G1V 4G5, Canada
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Beijing, 100142, China
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Beijing, 100210, China
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Changchun, 130021, China
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ACTIVE_NOT_RECRUITING

Changsha, 410013, China
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Chengdu, 610042, China
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WITHDRAWN

Chongqing, 400030, China
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ACTIVE_NOT_RECRUITING

Guangzhou, 510100, China
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Hangzhou, 310022, China
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Harbin, 150049, China
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Kunming, 650118, China
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Lanzhou, 730000, China
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Nanchang, 330006, China
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Ningbo, 315100, China
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Qingdao, 266003, China
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Shandong, China
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Shanghai, 200032, China
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Shenyang, 110044, China
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Taiyuan, 030000, China
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Taiyuan, 030032, China
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ACTIVE_NOT_RECRUITING

Tianjin, 300050, China
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ACTIVE_NOT_RECRUITING

Tianjin, 300060, China
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ACTIVE_NOT_RECRUITING

Wuhan, 430030, China
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TERMINATED

Xi'an, 710061, China
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ACTIVE_NOT_RECRUITING

Zhengzhou, 450008, China
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ACTIVE_NOT_RECRUITING

Zhengzhou, 450052, China
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ACTIVE_NOT_RECRUITING

Aarhus N, 8200, Denmark
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ACTIVE_NOT_RECRUITING

Copenhagen, 2100, Denmark
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COMPLETED

Brest, 29200, France
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ACTIVE_NOT_RECRUITING

Créteil, 94010, France
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Le Mans, 72037, France
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ACTIVE_NOT_RECRUITING

Lille, 59037, France
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Lyon, 69373, France
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Marseille, 13015, France
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Montpellier, 34298, France
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Paris, 75877, France
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ACTIVE_NOT_RECRUITING

Rouen, 76031, France
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Saint-Herblain, 44800, France
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ACTIVE_NOT_RECRUITING

Strasbourg, 67091, France
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ACTIVE_NOT_RECRUITING

Toulouse, 31059, France
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RECRUITING

Berlin, 13125, Germany
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RECRUITING

Berlin, 14109, Germany
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RECRUITING

Bochum, 44791, Germany
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Cologne, 51109, Germany
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Essen, 45122, Germany
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WITHDRAWN

Essen, 45130, Germany
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Gauting, 82131, Germany
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RECRUITING

Georgsmarienhütte, 49124, Germany
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Großhansdorf, 22927, Germany
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Hamburg, 21075, Germany
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Heidelberg, 69126, Germany
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Kiel, 24105, Germany
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RECRUITING

Münster, 48153, Germany
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RECRUITING

Regensburg, 93049, Germany
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ACTIVE_NOT_RECRUITING

Alessandria, 15100, Italy
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Bari, 70124, Italy
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Bergamo, 24125, Italy
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Milan, 20141, Italy
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Monza, 20052, Italy
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Orbassano, 10043, Italy
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Padova, 35128, Italy
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Parma, 43100, Italy
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ACTIVE_NOT_RECRUITING

Rozzano, 20089, Italy
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ACTIVE_NOT_RECRUITING

Varese, 21100, Italy
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ACTIVE_NOT_RECRUITING

Amagasaki-shi, 660-8550, Japan
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ACTIVE_NOT_RECRUITING

Hakodate-shi, 040-8611, Japan
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ACTIVE_NOT_RECRUITING

Hiroshima, 734-8551, Japan
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ACTIVE_NOT_RECRUITING

Kitaadachi-gun, 362-0806, Japan
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ACTIVE_NOT_RECRUITING

Kitakyushu-shi, 807-8555, Japan
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ACTIVE_NOT_RECRUITING

Matsuyama, 791-0280, Japan
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ACTIVE_NOT_RECRUITING

Nagoya, 466-8560, Japan
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ACTIVE_NOT_RECRUITING

Nishinomiya-shi, 663-8501, Japan
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ACTIVE_NOT_RECRUITING

Okayama, 702-8055, Japan
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ACTIVE_NOT_RECRUITING

Osakasayama-shi, 589-8511, Japan
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ACTIVE_NOT_RECRUITING

Tokyo, 104-0045, Japan
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ACTIVE_NOT_RECRUITING

Ube-shi, 755-0241, Japan
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ACTIVE_NOT_RECRUITING

Amsterdam, 1066CX, Netherlands
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ACTIVE_NOT_RECRUITING

Eindhoven, 5623EJ, Netherlands
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ACTIVE_NOT_RECRUITING

Rotterdam, 3015 GD, Netherlands
Research Site
COMPLETED

Lørenskog, 1478, Norway
Research Site
ACTIVE_NOT_RECRUITING

Oslo, 450, Norway
Research Site
WITHDRAWN

Bydgoszcz, 85-796, Poland
Research Site
ACTIVE_NOT_RECRUITING

Bystra, 43-360, Poland
Research Site
RECRUITING

Olsztyn, 10-357, Poland
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RECRUITING

Poznan, 60-569, Poland
Research Site
WITHDRAWN

Rzeszów, 35-241, Poland
Research Site
RECRUITING

Warsaw, 02-781, Poland
Research Site
ACTIVE_NOT_RECRUITING

Cape Town, 7570, South Africa
Research Site
ACTIVE_NOT_RECRUITING

eManzimtoti, 4126, South Africa
Research Site
ACTIVE_NOT_RECRUITING

Johannesburg, 2013, South Africa
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ACTIVE_NOT_RECRUITING

Johannesburg, 2193, South Africa
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ACTIVE_NOT_RECRUITING

Kimberly, 8301, South Africa
Research Site
WITHDRAWN

Polokwane, 0700, South Africa
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ACTIVE_NOT_RECRUITING

Pretoria, 0002, South Africa
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ACTIVE_NOT_RECRUITING

Pretoria, 0081, South Africa
Research Site
WITHDRAWN

Cheongju-si, 28644, South Korea
Research Site
ACTIVE_NOT_RECRUITING

Seoul, 03080, South Korea
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RECRUITING

Seoul, 06351, South Korea
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RECRUITING

Seoul, 06591, South Korea
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RECRUITING

Ulsan, 44033, South Korea
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RECRUITING

Barakaldo, 48903, Spain
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ACTIVE_NOT_RECRUITING

Barcelona, 8035, Spain
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ACTIVE_NOT_RECRUITING

Madrid, 28041, Spain
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RECRUITING

Oviedo, 33011, Spain
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ACTIVE_NOT_RECRUITING

Baden, CH-5405, Switzerland
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Basel, 4031, Switzerland
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Bern, 3010, Switzerland
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Fribourg, 1700, Switzerland
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Sankt Gallen, 9007, Switzerland
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ACTIVE_NOT_RECRUITING

Kaohsiung City, 80756, Taiwan
Research Site
ACTIVE_NOT_RECRUITING

Taichung, 40705, Taiwan
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WITHDRAWN

Tainan, 70403, Taiwan
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ACTIVE_NOT_RECRUITING

Taipei, 10002, Taiwan
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RECRUITING

Taoyuan District, 333, Taiwan
Research Site
WITHDRAWN

Adana, 01060, Turkey (Türkiye)
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SUSPENDED

Ankara, 06280, Turkey (Türkiye)
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ACTIVE_NOT_RECRUITING

Ankara, 06800, Turkey (Türkiye)
Research Site
ACTIVE_NOT_RECRUITING

Diyarbakır, 21280, Turkey (Türkiye)
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ACTIVE_NOT_RECRUITING

Izmir, 35110, Turkey (Türkiye)
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ACTIVE_NOT_RECRUITING

Cambridge, CB20QQ, United Kingdom
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WITHDRAWN

Cardiff, Wales, CF5 6NF, United Kingdom
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ACTIVE_NOT_RECRUITING

Leeds, LS9 7TF, United Kingdom
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ACTIVE_NOT_RECRUITING

Leicester, LE1 5WW, United Kingdom
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ACTIVE_NOT_RECRUITING

London, NW1 2PG, United Kingdom
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ACTIVE_NOT_RECRUITING

London, SE1 9RT, United Kingdom
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ACTIVE_NOT_RECRUITING

London, SW3 6JJ, United Kingdom
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ACTIVE_NOT_RECRUITING

Manchester, M23 9LT, United Kingdom
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ACTIVE_NOT_RECRUITING

Newcastle upon Tyne, NE2 4HH, United Kingdom
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ACTIVE_NOT_RECRUITING

Portsmouth, PO6 3LY, United Kingdom
Research Site
ACTIVE_NOT_RECRUITING

Taunton, TA1 5DA, United Kingdom
Research Site
WITHDRAWN

Phoenix, Arizona, 85054, United States
Research Site
WITHDRAWN

Duarte, California, 91010, United States
Research Site
RECRUITING

Santa Rosa, California, 95403, United States
Research Site
RECRUITING

Aurora, Colorado, 80045, United States
Research Site
RECRUITING

Jacksonville, Florida, 32224, United States
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RECRUITING

Atlanta, Georgia, 30322, United States
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RECRUITING

Chicago, Illinois, 60637, United States
Research Site
RECRUITING

Baltimore, Maryland, 21231, United States
Research Site
RECRUITING

Rochester, Minnesota, 55905, United States
Research Site
RECRUITING

St Louis, Missouri, 63110, United States
Research Site
WITHDRAWN

East Brunswick, New Jersey, 08816, United States
Research Site
RECRUITING

Commack, New York, 11725, United States
Research Site
RECRUITING

Valhalla, New York, 10595, United States
Research Site
WITHDRAWN

Cleveland, Ohio, 44111, United States
Research Site
WITHDRAWN

Cleveland, Ohio, 44124, United States
Research Site
WITHDRAWN

Cleveland, Ohio, 44195, United States

Conditions

Explore the condition pages connected to this study.

UNRESECTABLE PLEURAL MESOTHELIOMA