New combo could spare elderly lymphoma patients from full chemo

NCT ID NCT07215585

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 12, 2026 · Updated 24 times

Summary

This study tests whether a shorter course of chemotherapy followed by a targeted drug called AZD0486 works as well as the full standard chemo regimen for older or frail adults newly diagnosed with large B-cell lymphoma. About 420 participants will be randomly assigned to one of the two treatment plans. The goal is to see if the shorter approach reduces side effects while still controlling the disease.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

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Melbourne, 3000, Australia
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Nedlands, 6009, Australia
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Waratah, 2298, Australia
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Antwerp, 2030, Belgium
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Brussels, 1200, Belgium
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Ghent, 9000, Belgium
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Leuven, 3000, Belgium
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Roeselare, 8800, Belgium
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Yvoir, 5530, Belgium
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Porto Alegre, 90035-003, Brazil
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São Paulo, 05652000, Brazil
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Calgary, Alberta, T2N 5G2, Canada
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Ottawa, Ontario, K1H 8L6, Canada
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Beijing, 100730, China
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Changchun, 130021, China
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Chengdu, 610041, China
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Chongqing, 400042, China
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Fuzhou, 350011, China
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Guangzhou, 510060, China
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Guangzhou, 510280, China
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Haikou, 570311, China
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Hefei, 230012, China
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Jinan, 250117, China
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Kunming, 650101, China
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Nanchang, 330000, China
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Nanning, 530021, China
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Nantong, 226001, China
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Shanghai, 200003, China
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Shanghai, 20032, China
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Wuhan, 430030, China
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Xiamen, 361003, China
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Hong Kong, 999077, Hong Kong
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Lai Chi Kok, Hong Kong
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Shatin, 00000, Hong Kong
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Akashi, 673-8558, Japan
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Bunkyō City, 113-8677, Japan
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Himeji-shi, 670-8540, Japan
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Kōtoku, 135-8550, Japan
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Kumamoto, 860-8556, Japan
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Matsumoto-shi, 399-8701, Japan
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Matsuyama, 791-0280, Japan
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Meguro-ku, 152-8902, Japan
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Nagoya, 460-0001, Japan
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Osaka, 543-8555, Japan
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Osaka, 545-8586, Japan
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Otaki-Shi, 739-0696, Japan
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Sunto-gun, 411-8777, Japan
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Yamagata, 990-9585, Japan
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Yokohama, 241-8515, Japan
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Kielce, 25-734, Poland
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Krakow, 30-727, Poland
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Lodz, 93-513, Poland
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Lublin, 20-090, Poland
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Wroclaw, 50-367, Poland
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Seoul, 03080, South Korea
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Seoul, 5505, South Korea
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Ankara, 06620, Turkey (Türkiye)
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Antalya, 07025, Turkey (Türkiye)
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Glasgow, Scotland, G12 0YN, United Kingdom
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London, NW1 2PG, United Kingdom
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Newcastle upon Tyne, NE7 7AF, United Kingdom
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Nottingham, NG5 1PB, United Kingdom

Conditions

Explore the condition pages connected to this study.

LARGE B-CELL LYMPHOMA